Q12518
Gene name |
ENT1 (YDL161W) |
Protein name |
Epsin-1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL161W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for Q12518
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5AHV | EM | 1360 A | E | 1-154 | PDB |
| 5LOZ | X-ray | 195 A | A | 17-150 | PDB |
| 5ONF | X-ray | 280 A | A/B/C | 1-154 | PDB |
| 7B2L | EM | 390 A | A/C/F/H/K/M/P/R | 1-157 | PDB |
| AF-Q12518-F1 | Predicted | AlphaFoldDB |
3 variants for Q12518
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-167827 | 38 | S>L | No | SGRP | |
| s04-167860 | 49 | S>N | No | SGRP | |
| s04-168571 | 286 | Q>P | No | SGRP |
No associated diseases with Q12518
3 regional properties for Q12518
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Ubiquitin interacting motif | 165 - 184 | IPR003903-1 |
| conserved_site | Ubiquitin interacting motif | 189 - 208 | IPR003903-2 |
| domain | ENTH domain | 11 - 143 | IPR013809 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cellular bud neck | The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. |
| cellular bud tip | The end of a cellular bud distal to the site of attachment to the mother cell. |
| clathrin vesicle coat | A clathrin coat found on a vesicle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| mating projection tip | The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin binding | Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. |
| phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cortical patch assembly | Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. |
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKQFVRSAK | NLVKGYSSTQ | VLVRNATSND | NHQVSKDSLI | ELAEKSYDSA | DFFEIMDMLD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRLNDKGKYW | RHIAKALTVI | DYLIRFGSEN | CVLWCRENLY | IIKTLKEFRH | EDDEGIDQGQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IVRVKAKELT | ALLSDDERLN | EERNMNIKGR | NRKGRRRRGT | GRSDENDDDL | QRAISASRLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AEEDERRRKQ | DEDYETALQL | SKEEEELKRL | QDLQRMQQQQ | GQQQLQQPMY | YDIFGNPITP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EEYAQFQLQQ | QQQQQQQQLQ | QQPMYYDVFG | NPITPEELAQ | FQQQQQLQEQ | QYLASMQQQQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QAMSNNPFAK | SEQSSSSPKR | NQLVAASSPQ | QLQQQKQQEP | LIQNRTGNQS | MTDKYSKLNE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLATGTGIDT | FGNVGEARIP | AQHTKTGTFI | NSQGTGYRQV | SDDPNHNPFL | NSQYTGLPST |
| 430 | 440 | 450 | |||
| SVVPTQTGYG | FGNQSQQQSQ | NNGSNNRGYT | LIDL |