Q07872

PR
Gene name
ENT4 (YLL038C)
Protein name
Epsin-4
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLL038C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

137-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q07872

Entry ID Method Resolution Chain Position Source
AF-Q07872-F1 Predicted AlphaFoldDB

5 variants for Q07872

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-66234 95 I>T No SGRP
s12-66168 117 R>Q No SGRP
s12-66128 130 R>S No SGRP
s12-66112 136 L>V No SGRP
s12-65991 176 S>N No SGRP

No associated diseases with Q07872

1 regional properties for Q07872

Type Name Position InterPro Accession
domain ENTH domain 7 - 146 IPR013809

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
actin cortical patch An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
clathrin binding Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.

4 GO annotations of biological process

Name Definition
actin cortical patch assembly Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q12518 ENT1 Epsin-1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8IYW4 ENTHD1 ENTH domain-containing protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MPLLDTFKSF IQSPTESKVK QATNEDETSG ATGTLMNEIS ILTYSPKTVR EIIQVIRKRL
70 80 90 100 110 120
LLGQNRRNSH RNCIQVMKTL TLVSYLMNNG SNEFIKWLKG NMILIEILED FQVQDPRDER
130 140 150 160 170 180
KAEDIQKLSR NVLGLLQDDG LLEKQRKDVI QFRSSISTPG RKSTDNSHLK LEEMRSELTR
190 200 210 220 230 240
QSLEKKAKPP TTSTSLDFQR QRTRNTHEYA RFSLDPLAEE DSEDTPGVAG GISKLSFRPK
SSNNPFR