Q12509
Gene name |
ARP6 (YLR085C, L2393, L9449.13) |
Protein name |
Actin-like protein ARP6 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR085C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q12509
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6GEJ | EM | 360 A | R | 1-438 | PDB |
| 6GEN | EM | 360 A | R | 1-438 | PDB |
| AF-Q12509-F1 | Predicted | AlphaFoldDB |
8 variants for Q12509
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-301930 | 21 | T>A | No | SGRP | |
| s12-301540 | 151 | S>A | No | SGRP | |
| s12-301521 | 157 | I>T | No | SGRP | |
| s12-301473 | 173 | E>G | No | SGRP | |
| s12-301173 | 273 | E>G | No | SGRP | |
| s12-301123 | 290 | P>S | No | SGRP | |
| s12-300918 | 358 | G>A | No | SGRP | |
| s12-300762 | 410 | R>L | No | SGRP |
No associated diseases with Q12509
No regional properties for Q12509
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q12509 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear periphery | The portion of the nuclear lumen proximal to the inner nuclear membrane. |
| Swr1 complex | A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| nucleosome binding | Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone exchange | The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| METPPIVIDN | GSYEIKFGPS | TNKKPFRALN | ALAKDKFGTS | YLSNHIKNIK | DISSITFRRP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HELGQLTLWE | LESCIWDYCL | FNPSEFDGFD | LKEGKGHHLV | ASESCMTLPE | LSKHADQVIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEYEFDSLFK | SPVAVFVPFT | KSYKGEMRTI | SGKDEDIDIV | RGNSDSTNST | SSESKNAQDS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GSDYHDFQLV | IDSGFNCTWI | IPVLKGIPYY | KAVKKLDIGG | RFLTGLLKET | LSFRHYNMMD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ETILVNNIKE | QCLFVSPVSY | FDSFKTKDKH | ALEYVLPDFQ | TSFLGYVRNP | RKENVPLPED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AQIITLTDEL | FTIPETFFHP | EISQITKPGI | VEAILESLSM | LPEIVRPLMV | GNIVCTGGNF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLPNFAQRLA | AELQRQLPTD | WTCHVSVPEG | DCALFGWEVM | SQFAKTDSYR | KARVTREEYY |
| 430 | |||||
| EHGPDWCTKH | RFGYQNWI |