Q12504

PR
Gene name
RKM4
Protein name
Ribosomal lysine N-methyltransferase 4
Names
SET domain-containing protein 7
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR257C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

167-246 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q12504

Entry ID Method Resolution Chain Position Source
AF-Q12504-F1 Predicted AlphaFoldDB

9 variants for Q12504

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-971437 12 V>I No SGRP
s04-971149 108 A>T No SGRP
s04-970876 199 V>I No SGRP
s04-970824 216 R>H No SGRP
s04-970569 301 K>T No SGRP
s04-970563 303 T>N No SGRP
s04-970495 326 E>K No SGRP
s04-970490 327 F>L No SGRP
s04-970240 411 A>T No SGRP

No associated diseases with Q12504

2 regional properties for Q12504

Type Name Position InterPro Accession
domain SET domain 25 - 265 IPR001214
domain SETD6, SET domain 21 - 281 IPR044430

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.

1 GO annotations of biological process

Name Definition
peptidyl-lysine monomethylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08961 RKM1 Ribosomal lysine N-methyltransferase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MDDFSRDTEN FVCWLKTTAE IEVSPKIEIK DLCCDNQGRA VVATQKIKKD ETLFKIPRSS
70 80 90 100 110 120
VLSVTTSQLI KDYPSLKDKF LNETGSWEGL IICILYEMEV LQERSRWAPY FKVWNKPSDM
130 140 150 160 170 180
NALIFWDDNE LQLLKPSLVL ERIGKKEAKE MHERIIKSIK QIGGEFSRVA TSFEFDNFAY
190 200 210 220 230 240
IASIILSYSF DLEMQDSSVN ENEEEETSEE ELENERYLKS MIPLADMLNA DTSKCNANLT
250 260 270 280 290 300
YDSNCLKMVA LRDIEKNEQV YNIYGEHPNS ELLRRYGYVE WDGSKYDFGE VLLENIVEAL
310 320 330 340 350 360
KETFETNTEF LDRCIDILRN NANIQEFLEG EEIVLDSYDC YNNGELLPQL ILLVQILTIL
370 380 390 400 410 420
CQIPGLCKLD IKAMERQVER IVKKCLQLIE GARATTNCSA TWKRCIMKRL ADYPIKKCVS
430 440 450 460 470 480
IEKPSKGNSL TREELRDVMA RRVLKSEIDS LQVCEETIDK NYKVIPDEKL LTNILKRKLT
490
EEEKSSVKRP CVKK