Q08961
Gene name |
RKM1 |
Protein name |
Ribosomal lysine N-methyltransferase 1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YPL208W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q08961
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q08961-F1 | Predicted | AlphaFoldDB |
11 variants for Q08961
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s16-158026 | 62 | K>N | No | SGRP | |
| s16-158081 | 81 | F>L | No | SGRP | |
| s16-158126 | 96 | N>D | No | SGRP | |
| s16-158237 | 133 | I>L | No | SGRP | |
| s16-158278 | 146 | K>N | No | SGRP | |
| s16-158867 | 343 | A>T | No | SGRP | |
| s16-158990 | 384 | L>V | No | SGRP | |
| s16-159077 | 413 | A>P | No | SGRP | |
| s16-159149 | 437 | Q>K | No | SGRP | |
| s16-159408 | 523 | Q>R | No | SGRP | |
| s16-159486 | 549 | D>G | No | SGRP |
No associated diseases with Q08961
1 regional properties for Q08961
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SET domain | 22 - 274 | IPR001214 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-lysine N-methyltransferase activity | Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| peptidyl-lysine dimethylation | The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. |
| peptidyl-lysine monomethylation | The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12504 | RKM4 | Ribosomal lysine N-methyltransferase 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSDALKALL | QWGASFGVIV | PEELKFLYTD | LKGIICVCEK | DIDNPSIKIP | PEIVISRNLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MKFFGLSEST | KNINGWLKLF | FAKIKFDRDN | DTIVDNVRVN | DKFKPYLDAL | PSRLNSPLVW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPSELKRLSS | TNIGNSIHEK | FEGIFKEWFE | LVSSSDMFDL | ERVADDVQTF | HNLDELTYEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LYEKILKITE | LQRPTIWYSF | PAFLWSHLIF | ISRAFPEYVL | NRNCPDNSIV | LLPIVDLLNH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DYRSKVKWYP | ENGWFCYEKI | GTASQSRELS | NNYGGKGNEE | LLSGYGFVLE | DNIFDSVALK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VKLPLDVVST | ILETEPSLKL | PLLSDYTTYA | FENKDCVQQE | KKATRSATDY | INGVTYFINI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QNEQCLEPLL | DLFTYLSKAE | EEDLHDLRAR | LQGIQMLRNA | LQSKLNSITG | PPATDDSYAI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DPYRVYCADV | YTKGQKQILK | EALTRLKKLE | KTMLSENKHQ | LLTMSKILKN | DPAFAETELP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLFSNEDGEE | VIFESTYDLL | ILWILLKTKK | NSYPTKYEWV | GQQYTNFKQT | AYISDDAKAF |
| 550 | 560 | 570 | 580 | ||
| HTAYFEKQDD | VDLAEVDHAI | QFVVDNSFTR | TSSTTEETIL | VRK |