Q12449

PR
Gene name
AHA1 (YDR214W, YD8142.16, YD8142B.06)
Protein name
Hsp90 co-chaperone AHA1
Names
Activator of Hsp90 ATPase protein 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR214W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

143-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for Q12449

Entry ID Method Resolution Chain Position Source
1USU X-ray 215 A B 1-156 PDB
1USV X-ray 270 A B/D/F/H 1-156 PDB
6XLB EM 380 A C1/D1 1-350 PDB
6XLD EM 366 A C 1-350 PDB
6XLE EM 274 A C/D 1-350 PDB
6XLF EM 315 A C/D 1-350 PDB
6XLG EM 271 A C/D 1-350 PDB
6XLH EM 283 A C/D 1-350 PDB
AF-Q12449-F1 Predicted AlphaFoldDB

7 variants for Q12449

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-893120 83 D>E No SGRP
s04-893134 88 P>L No SGRP
s04-893153 94 N>K No SGRP
s04-893424 185 K>E No SGRP
s04-893439 190 P>S No SGRP
s04-893482 204 K>R No SGRP
s04-893748 293 P>A No SGRP

No associated diseases with Q12449

2 regional properties for Q12449

Type Name Position InterPro Accession
domain Activator of Hsp90 ATPase homologue 1-like, C-terminal 223 - 342 IPR013538
domain Activator of Hsp90 ATPase AHSA1-like, N-terminal 5 - 152 IPR015310

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity.
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.

2 GO annotations of biological process

Name Definition
positive regulation of ATP-dependent activity Any process that activates or increases the rate of an ATP-dependent activity.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q719I0 AHSA2P Putative activator of 90 kDa heat shock protein ATPase homolog 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MVVNNPNNWH WVDKNCIGWA KEYFKQKLVG VEAGSVKDKK YAKIKSVSSI EGDCEVNQRK
70 80 90 100 110 120
GKVISLFDLK ITVLIEGHVD SKDGSALPFE GSINVPEVAF DSEASSYQFD ISIFKETSEL
130 140 150 160 170 180
SEAKPLIRSE LLPKLRQIFQ QFGKDLLATH GNDIQVPESQ VKSNYTRGNQ KSSFTEIKDS
190 200 210 220 230 240
ASKPKKNALP SSTSTSAPVS STNKVPQNGS GNSTSIYLEP TFNVPSSELY ETFLDKQRIL
250 260 270 280 290 300
AWTRSAQFFN SGPKLETKEK FELFGGNVIS ELVSCEKDKK LVFHWKLKDW SAPFNSTIEM
310 320 330 340
TFHESQEFHE TKLQVKWTGI PVGEEDRVRA NFEEYYVRSI KLTFGFGAVL