AiPD: Autoinhibited Protein Database

Gene name	MLH3 (YPL164C, P2550)
Protein name	DNA mismatch repair protein MLH3
Names	MutL protein homolog 3
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YPL164C
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

351-492 (Predicted disordered autoinhibitory region) PR

351-492 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
6RMN	X-ray	220 A	B	477-714	PDB
6SHX	X-ray	240 A	B	477-715	PDB
6SNS	X-ray	260 A	B	477-715	PDB
6SNV	X-ray	250 A	B/E	477-715	PDB
AF-Q12083-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s16-241466	11	D>N	No	SGRP
s16-241173	108	N>K	No	SGRP
s16-241078	140	P>L	No	SGRP
s16-241052	149	P>A	No	SGRP
s16-241044	151	S>R	No	SGRP
s16-240680	273	G>R	No	SGRP
s16-240368	377	T>A	No	SGRP
s16-240335	388	V>F	No	SGRP
s16-240302	399	D>N	No	SGRP
s16-240292	402	I>S	No	SGRP
s16-240214	428	A>V	No	SGRP
s16-240152	449	I>L	No	SGRP
s16-240132	455	R>S	No	SGRP
s16-240127	457	R>Q	No	SGRP
s16-240094	468	G>D	No	SGRP
s16-239951	516	C>R	No	SGRP
s16-239743	585	T>I	No	SGRP
s16-239708	597	I>V	No	SGRP
s16-239610	629	F>L	No	SGRP
s16-239573	642	Y>H	No	SGRP
s16-239410	696	H>R	No	SGRP

Type	Name	Position	InterPro Accession
domain	DNA mismatch repair protein, S5 domain 2-like	238 - 371	IPR013507
domain	MutL, C-terminal, dimerisation	495 - 680	IPR014790

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
mismatch repair complex	Any complex formed of proteins that act in mismatch repair.
MutLgamma complex	A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity	A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding	Binding to a double-stranded DNA region containing one or more mismatches.

Name	Definition
meiotic mismatch repair	A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis.
mismatch repair	A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
reciprocal meiotic recombination	The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P14242	PMS1	DNA mismatch repair protein PMS1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR