AiPD: Autoinhibited Protein Database

Gene name	PMS1 (YNL082W, N2317)
Protein name	DNA mismatch repair protein PMS1
Names	Postmeiotic segregation protein 1
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YNL082W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

348-442 (Predicted disordered autoinhibitory region) PR

348-442 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3H4L	X-ray	250 A	A/B	1-365	PDB
4E4W	X-ray	250 A	B	635-873	PDB
4FMN	X-ray	269 A	B	635-873	PDB
4FMO	X-ray	304 A	B	635-873	PDB
AF-P14242-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
s14-473513	41	N>S	strain: SK1 and YJM421 [UniProt]	No	SGRP
s14-473581	64	I>V		No	SGRP
s14-473726	112	I>T	strain: SK1 and YJM421 [UniProt]	No	SGRP
s14-473948	186	I>T		No	SGRP
s14-474125	245	G>E		No	SGRP
s14-474257	289	P>L		No	SGRP
s14-474541	384	F>V	strain: SK1, YJM320, YJM339 and YJM421 [UniProt]	No	SGRP
	392	E>V	strain: YJM320 [UniProt]	No
s14-474590	400	T>S	strain: SK1, YJM320, YJM339 and YJM421 [UniProt]	No	SGRP
s14-474592	401	A>S	strain: YJM320 and YJM421 [UniProt]	No	SGRP
	416	T>TCEGT	strain: SK1, YJM320, YJM339 and YJM421 [UniProt]	No
s14-474763	458	D>Y	strain: EAY1068 [UniProt]	No	SGRP
	475	D>N	strain: YJM339 [UniProt]	No
s14-474821	477	Q>R		No	SGRP
s14-474886	499	D>N		No	SGRP
s14-474929	513	Y>F	strain: SK1 [UniProt]	No	SGRP
s14-475039	550	Q>K		No	SGRP
s14-475058	556	T>S		No	SGRP
	564	A>V	strain: YJM320 [UniProt]	No
s14-475118	576	I>T		No	SGRP
s14-475139	583	K>R		No	SGRP
s14-475537	716	A>T		No	SGRP
s14-475694	768	K>R	strain: YJM320 [UniProt]	No	SGRP
s14-475844	818	R>K	strain: SK1 and YJM320; forms a non-functional heterodimer with MHL1 from strain S288c, resulting in an accumulation of mutations in spore progeny of crosses between these strains [UniProt]	No	SGRP
s14-476008	873	I>V		No	SGRP

Type	Name	Position	InterPro Accession
domain	DNA mismatch repair protein, S5 domain 2-like	215 - 357	IPR013507
conserved_site	DNA mismatch repair, conserved site	94 - 100	IPR014762
domain	MutL, C-terminal, dimerisation	675 - 827	IPR014790

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mismatch repair complex	Any complex formed of proteins that act in mismatch repair.
MutLalpha complex	A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity	A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
mismatched DNA binding	Binding to a double-stranded DNA region containing one or more mismatches.

Name	Definition
meiotic mismatch repair	A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis.
mismatch repair	A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q12083	MLH3	DNA mismatch repair protein MLH3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR