Q0X0C4

PR
Gene name
HEXIM1
Protein name
Protein HEXIM1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:539696
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-304 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0X0C4

Entry ID Method Resolution Chain Position Source
AF-Q0X0C4-F1 Predicted AlphaFoldDB

210 variants for Q0X0C4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs456104596 2 A>P No EVA
rs432059792 4 P>Q No EVA
rs471823094 6 L>W No EVA
rs440536981 8 E>D No EVA
rs454306345 9 F>I No EVA
rs454306345 9 F>L No EVA
rs474294068 11 H>P No EVA
rs442838870 11 H>Q No EVA
rs462957790 13 P>R No EVA
rs438900563 16 S>N No EVA
rs458952788 16 S>R No EVA
rs478831473 17 N>I No EVA
rs461286179 21 A>S No EVA
rs449854672 22 V>L No EVA
rs431927157 25 H>P No EVA
rs445746490 26 E>G No EVA
rs465677330 27 E>A No EVA
rs434184593 27 E>D No EVA
rs454172672 29 N>I No EVA
rs474359676 29 N>K No EVA
rs436694342 32 R>S No EVA
rs476661795 33 P>L No EVA
rs456739152 33 P>S No EVA
rs456739152 33 P>T No EVA
rs472674119 36 A>S No EVA
rs441090464 37 E>V No EVA
rs449982710 38 E>A No EVA
rs481235798 38 E>Q No EVA
rs463593743 39 R>G No EVA
rs445574633 40 V>G No EVA
rs477068450 40 V>L No EVA
rs477068450 40 V>M No EVA
rs465740620 42 E>Q No EVA
rs434448462 43 E>A No EVA
rs434448462 43 E>G No EVA
rs467817890 45 S>R No EVA
rs436550536 47 W>G No EVA
rs436550536 47 W>R No EVA
rs456846138 48 Q>K No EVA
rs476921751 49 S>* No EVA
rs432395861 50 R>K No EVA
rs452523726 50 R>S No EVA
rs472539049 51 A>V No EVA
rs441348269 53 P>H No EVA
rs454993309 54 K>* No EVA
rs474849014 55 S>A No EVA
rs477336965 59 P>Q No EVA
rs459190033 61 H>P No EVA
rs479173487 61 H>Q No EVA
rs459190033 61 H>R No EVA
rs468082802 64 E>G No EVA
rs450188190 65 G>R No EVA
rs432679045 67 L>R No EVA
rs466179623 68 E>A No EVA
rs434743164 68 E>D No EVA
rs452785990 68 E>K No EVA
rs455056769 69 P>A No EVA
rs443454805 70 Q>R No EVA
rs457074331 71 P>A No EVA
rs470763545 72 S>P No EVA
rs470763545 72 S>T No EVA
rs459450867 73 P>L No EVA
rs441549764 76 T>P No EVA
rs441549764 76 T>S No EVA
rs461894627 77 Q>R No EVA
rs481970821 78 V>D No EVA
rs450516883 79 C>S No EVA
rs470382630 81 E>V No EVA
rs446381258 82 S>Y No EVA
rs434808661 84 C>R No EVA
rs454913655 87 A>S No EVA
rs468746820 92 Q>H No EVA
rs437287470 94 G>W No EVA
rs457398088 98 S>P No EVA
rs432920204 101 G>V No EVA
rs441611202 107 R>K No EVA
rs461712129 109 V>G No EVA
rs444108790 114 H>Q No EVA
rs475402929 114 H>R No EVA
rs457812873 116 R>G No EVA
rs477624390 117 R>G No EVA
rs460077466 124 L>R No EVA
rs480107605 125 W>C No EVA
rs468561869 128 Y>* No EVA
rs479730952 128 Y>D No EVA
rs437156455 130 T>P No EVA
rs464473399 132 T>P No EVA
rs432985578 132 T>S No EVA
rs452983480 133 W>G No EVA
rs452983480 133 W>R No EVA
rs472960804 135 E>D No EVA
rs435464790 136 K>Q No EVA
rs475428102 138 K>M No EVA
rs443993612 138 K>N No EVA
rs471484531 139 F>C No EVA
rs457800439 139 F>I No EVA
rs439878601 139 F>L No EVA
rs459938846 140 D>H No EVA
rs459938846 140 D>N No EVA
rs479972176 141 E>K No EVA
rs462424616 142 K>N No EVA
rs448701175 142 K>R No EVA
rs482308732 143 Q>E No EVA
rs450858239 144 S>G No EVA
rs464538769 144 S>T No EVA
rs433248758 145 L>R No EVA
rs466619613 146 R>G No EVA
rs469288320 147 A>G No EVA
rs455578564 147 A>P No EVA
rs455578564 147 A>S No EVA
rs469288320 147 A>V No EVA
rs437628377 148 S>P No EVA
rs451281596 148 S>W No EVA
rs471347189 149 R>G No EVA
rs453794446 150 I>F No EVA
rs453794446 150 I>L No EVA
rs473618138 151 R>* No EVA
rs442188183 153 E>G No EVA
rs462460311 154 M>V No EVA
rs482565767 156 A>G No EVA
rs444642413 159 Q>P No EVA
rs457987114 160 P>A No EVA
rs477973336 166 T>P No EVA
rs446920994 168 Q>E No EVA
rs466881221 170 L>P No EVA
rs480507672 172 D>N No EVA
rs449062006 173 D>N No EVA
rs469301687 174 H>P No EVA
rs469301687 174 H>R No EVA
rs437896764 176 Q>H No EVA
rs451580195 178 E>* No EVA
rs464980624 183 T>P No EVA
rs433534783 184 G>A No EVA
rs433534783 184 G>V No EVA
rs473914969 185 L>R No EVA
rs455916527 187 P>S No EVA
rs475964662 188 K>N No EVA
rs444741748 194 S>C No EVA
rs458247192 196 D>A No EVA
rs478034888 197 T>P No EVA
rs440348324 199 D>E No EVA
rs460518255 201 D>A No EVA
rs480748348 204 E>G No EVA
rs469214775 210 D>G No EVA
rs482854664 211 G>V No EVA
rs445179025 213 S>I No EVA
rs465244248 221 S>G No EVA
rs433598299 221 S>R No EVA
rs467291418 222 E>G No EVA
rs447272520 222 E>K No EVA
rs436097067 223 F>V No EVA
rs456132093 231 T>P No EVA
rs876142174 235 Y>D No EVA
rs438135334 244 S>I No EVA
rs476070246 244 S>R No EVA
rs451924957 252 Y>D No EVA
rs440411955 261 R>G No EVA
rs460379448 261 R>H No EVA
rs474170084 262 M>L No EVA
rs442929112 267 N>K No EVA
rs462985005 268 R>G No EVA
rs445036893 270 R>G No EVA
rs478906958 272 E>* No EVA
rs447540634 275 R>P No EVA
rs467403616 276 L>V No EVA
rs435956850 277 D>A No EVA
rs449792991 277 D>E No EVA
rs435956850 277 D>G No EVA
rs469849519 278 G>R No EVA
rs471761414 279 D>G No EVA
rs451788012 279 D>H No EVA
rs454311475 280 D>A No EVA
rs474247893 280 D>E No EVA
rs454311475 280 D>G No EVA
rs434258447 280 D>H No EVA
rs463096747 281 A>G No EVA
rs442775273 281 A>P No EVA
rs442775273 281 A>S No EVA
rs476696824 282 R>H No EVA
rs476696824 282 R>P No EVA
rs478768189 283 V>E No EVA
rs478768189 283 V>G No EVA
rs458737556 283 V>L No EVA
rs461180052 284 R>G No EVA
rs449592901 285 E>D No EVA
rs481092905 285 E>G No EVA
rs469944780 286 L>V No EVA
rs445665790 287 E>A No EVA
rs445665790 287 E>G No EVA
rs445665790 287 E>V No EVA
rs465415543 288 L>P No EVA
rs465415543 288 L>R No EVA
rs434123366 289 E>A No EVA
rs434123366 289 E>G No EVA
rs468033258 290 L>R No EVA
rs456468587 291 D>G No EVA
rs438936582 293 L>V No EVA
rs452599033 294 R>G No EVA
rs452599033 294 R>S No EVA
rs440975759 295 A>G No EVA
rs481371930 296 E>G No EVA
rs443466447 297 N>K No EVA
rs463196169 298 L>P No EVA
rs476773448 299 Q>P No EVA
rs445729353 300 L>M No EVA
rs465677462 301 L>M No EVA
rs479050406 302 T>A No EVA
rs447781473 307 H>P No EVA
rs468143254 313 A>G No EVA
rs379668406 314 P>S No EVA

No associated diseases with Q0X0C4

No regional properties for Q0X0C4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q0X0C4

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Binds alpha-importin and is mostly nuclear
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
7SK snRNP A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
7SK snRNA binding Binding to a 7SK small nuclear RNA (7SK snRNA).
cyclin-dependent protein serine/threonine kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.
identical protein binding Binding to an identical protein or proteins.
P-TEFb complex binding Binding to a P-TEFb complex.

7 GO annotations of biological process

Name Definition
activation of innate immune response Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of cyclin-dependent protein serine/threonine kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of viral transcription Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.
positive regulation of signal transduction by p53 class mediator Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96MH2 HEXIM2 Protein HEXIM2 Homo sapiens (Human) PR
O94992 HEXIM1 Protein HEXIM1 Homo sapiens (Human) SS
10 20 30 40 50 60
MAEPLLSEFQ HQPQTSNCTG AVAVHEERNP DRPPGAEERV PEEDSRWQSR ASPKSGGSPG
70 80 90 100 110 120
HGGEGSLEPQ PSPLKTQVCP ESSCPEAGEK GQNGDDLSAG GAPPQQRQVG KKKHRRRPSK
130 140 150 160 170 180
KKRLWKPYYT LTWEEKKKFD EKQSLRASRI RAEMFAKGQP VAPYNTTQFL MDDHDQEEPD
190 200 210 220 230 240
LKTGLYPKRA AAKSDDTSDE DFMEEAGEED GGSDGMGGDG SEFLQRDFSE TYERYHAESL
250 260 270 280 290 300
QNMSKQELIK EYLELEKCLS RMEDENNRLR LESQRLDGDD ARVRELELEL DRLRAENLQL
310
LTENELHRQQ ERAPLSNFGD