AiPD: Autoinhibited Protein Database

O94992

Gene name	HEXIM1 (CLP1, EDG1, HIS1, MAQ1)
Protein name	Protein HEXIM1
Names	Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:10614
EC number
Protein Class

Descriptions

(Annotation from UniProt)
HEXIM1 is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor.

Autoinhibitory domains (AIDs)

210-250 (Autoinhibitory acidic region) SS

Target domain	202-205 (P-TEFb interaction region)
Relief mechanism	Partner binding
Assay

AID

210-250 (Autoinhibitory acidic region)

Target domain

202-205 (P-TEFb interaction region)

Relief mechanism

Partner binding (7SK binding)

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for O94992

Entry ID	Method	Resolution	Chain	Position	Source
2GD7	NMR	-	A/B	255-359	PDB
3S9G	X-ray	210 A	A/B	255-359	PDB
AF-O94992-F1	Predicted				AlphaFoldDB

245 variants for O94992

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA8611956 rs761441239	2	A>D		No	ClinGen ExAC TOPMed gnomAD
CA399858013 rs1350671005	3	E>K		No	ClinGen gnomAD
rs754411480 CA8611958	4	P>R		No	ClinGen ExAC gnomAD
rs755261268 CA8611959	5	F>L		No	ClinGen ExAC TOPMed gnomAD
CA8611960 rs765719338	9	Y>C		No	ClinGen ExAC gnomAD
CA8611961 rs752910152	11	H>P		No	ClinGen ExAC gnomAD
rs758700108 CA8611962	13	P>L		No	ClinGen ExAC gnomAD
CA8611963 rs778210451	14	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs747061601 CA8611964	16	S>G		No	ClinGen ExAC gnomAD
rs373817429 CA291015664	16	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA8611965 rs373817429	16	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1282628191 CA399858120	18	C>F		No	ClinGen TOPMed
rs1332293289 CA399858127	19	T>I		No	ClinGen Ensembl
CA291015675 rs367729540	20	G>D		No	ClinGen ESP TOPMed
rs140416514 CA8611966	22	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8611967 rs745839893	23	A>V		No	ClinGen ExAC gnomAD
rs777735067 CA8611969	24	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1183486343 CA399858170	26	E>D		No	ClinGen gnomAD
CA291015698 rs370597507	30	P>L		No	ClinGen ESP gnomAD
CA399858200 rs1428912076	31	E>G		No	ClinGen TOPMed
CA8611971 rs768281978	31	E>K		No	ClinGen ExAC gnomAD
CA8611972 rs774042737	32	R>G		No	ClinGen ExAC gnomAD
CA399858204 rs774042737	32	R>S		No	ClinGen ExAC gnomAD
CA8611976 rs767088972	34	P>A		No	ClinGen ExAC TOPMed gnomAD
rs767088972 CA399858215	34	P>T		No	ClinGen ExAC TOPMed gnomAD
CA399858238 rs1372440542	37	E>D		No	ClinGen gnomAD
rs758892714 CA399858245	38	E>D		No	ClinGen ExAC gnomAD
rs758892714 CA8611981	38	E>D		No	ClinGen ExAC gnomAD
CA8611980 rs139710804	38	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs764378739 CA8611982	39	R>Q		No	ClinGen ExAC gnomAD
CA8611983 rs149955210	40	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8611984 rs149955210	40	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA291015818 rs994661450	41	P>S		No	ClinGen Ensembl
rs745722539 CA8611987	42	E>A		No	ClinGen ExAC gnomAD
rs903988968 CA291015819	42	E>K		No	ClinGen TOPMed gnomAD
CA399858259 rs903988968	42	E>Q		No	ClinGen TOPMed gnomAD
CA8611989 rs780022419	43	E>D		No	ClinGen ExAC gnomAD
rs756070648 CA8611988	43	E>K		No	ClinGen ExAC gnomAD
CA8611991 rs372695634	46	R>M		No	ClinGen ESP ExAC gnomAD
CA399858318 rs1436544175	50	R>K		No	ClinGen TOPMed gnomAD
rs868552409 CA291015835	51	A>E		No	ClinGen TOPMed
rs1567917731 CA399858323	51	A>T		No	ClinGen Ensembl
CA399858327 rs868552409	51	A>V		No	ClinGen TOPMed
rs772784303 CA8611995	52	F>S		No	ClinGen ExAC TOPMed gnomAD
CA399858340 rs1180267674	53	P>L		No	ClinGen TOPMed gnomAD
CA291015933 rs11558627	54	Q>H		No	ClinGen Ensembl
rs11558627 CA291015939	54	Q>H		No	ClinGen Ensembl
rs1190141107 CA399858341	54	Q>K		No	ClinGen gnomAD
CA8611996 rs760170895	56	G>R		No	ClinGen ExAC TOPMed gnomAD
rs770412496 CA8611997	58	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1168034197 CA399858371	59	P>A		No	ClinGen TOPMed gnomAD
rs1334775996 CA399858384	61	P>A		No	ClinGen gnomAD
CA8612000 rs764574971	62	E>D		No	ClinGen ExAC gnomAD
CA8612001 rs751673575	63	G>R		No	ClinGen ExAC TOPMed gnomAD
rs762094836 CA8612002	64	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8612003 rs767694506	66	S>I		No	ClinGen ExAC gnomAD
rs1346533085 CA399858438	69	S>F		No	ClinGen TOPMed gnomAD
rs1156906487 CA399858435	69	S>P		No	ClinGen gnomAD
CA399858451 rs1024700122	71	P>L		No	ClinGen TOPMed
CA291015990 rs1024700122	71	P>R		No	ClinGen TOPMed
CA291015991 rs967415341	72	P>L		No	ClinGen gnomAD
CA399858462 rs1279959416	73	P>L		No	ClinGen gnomAD
rs756233346 CA8612005	75	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs977466725 CA291015994	76	T>I		No	ClinGen Ensembl
CA399858478 rs1567917775	76	T>S		No	ClinGen Ensembl
rs753806975 CA8612007	77	Q>E		No	ClinGen ExAC gnomAD
rs1188224043 CA399858490	78	A>S		No	ClinGen gnomAD
CA399858499 rs1419783939	79	C>S		No	ClinGen TOPMed
rs147427660 CA8612009	80	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8612010 rs572482083	81	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1424394316 CA399858516	82	S>P		No	ClinGen gnomAD
CA8612011 rs536393664	83	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA399858527 rs536393664	83	S>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1161061696 CA399858533	84	C>F		No	ClinGen gnomAD
CA8612012 rs777350008	86	R>T		No	ClinGen ExAC TOPMed gnomAD
CA8612013 rs746508181	87	E>G		No	ClinGen ExAC gnomAD
rs776090403 CA8612015	88	G>D		No	ClinGen ExAC TOPMed gnomAD
CA291016055 rs975607932	88	G>S		No	ClinGen gnomAD
rs201788609 CA8612016	89	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs774768717 CA8612018	91	G>D		No	ClinGen ExAC TOPMed gnomAD
rs774768717 CA399858577	91	G>V		No	ClinGen ExAC TOPMed gnomAD
CA399858600 rs1208304257	95	D>Y		No	ClinGen gnomAD
rs1307931916 CA399858614	96	D>E		No	ClinGen TOPMed
rs372722263 CA291016082	96	D>N		No	ClinGen ESP TOPMed gnomAD
rs762138738 CA8612020	97	S>A		No	ClinGen ExAC TOPMed gnomAD
COSM1521387 CA8612021 rs767754935	97	S>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1230905768 CA399858622	98	S>Y		No	ClinGen TOPMed
CA8612022 rs201778839	99	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399858630 rs1479401477	100	G>S		No	ClinGen gnomAD
CA8612023 rs760708795	101	G>C		No	ClinGen ExAC TOPMed gnomAD
rs1385600674 CA399858649	103	F>I		No	ClinGen TOPMed
rs753721065 CA8612025	103	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1156426623 CA399858658	104	P>S		No	ClinGen gnomAD
rs1392413805 CA399858665	105	P>L		No	ClinGen gnomAD
rs778783867 CA399858692	109	V>A		No	ClinGen ExAC TOPMed gnomAD
rs778783867 CA8612027	109	V>G		No	ClinGen ExAC TOPMed gnomAD
rs12051846 CA399858699	110	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399858696 rs1403587482	110	E>G		No	ClinGen gnomAD
CA291016162 rs17850101	110	E>K		No	ClinGen Ensembl
rs1403587482 CA399858697	110	E>V		No	ClinGen gnomAD
CA8612030 rs371316696	111	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs756767765 CA8612032	112	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1210709779 CA399858713	113	P>H		No	ClinGen gnomAD
CA399858712 rs1358696096	113	P>S		No	ClinGen gnomAD
CA399858720 rs1489888388	114	E>G		No	ClinGen gnomAD
CA399858718 rs1289175326	114	E>K		No	ClinGen gnomAD
CA8612033 rs780853522	115	A>T		No	ClinGen ExAC gnomAD
CA399858728 rs1360903050	115	A>V		No	ClinGen Ensembl
CA291016187 rs775152336	116	E>D		No	ClinGen Ensembl
CA8612034 rs745438153	116	E>K		No	ClinGen ExAC TOPMed gnomAD
CA291016192 rs868242690	117	L>M		No	ClinGen Ensembl
rs769192457 CA8612035	118	L>F		No	ClinGen ExAC gnomAD
rs774768886 CA8612036	119	A>T		No	ClinGen ExAC gnomAD
CA291016200 rs867729042	120	Q>K		No	ClinGen Ensembl
CA291016201 rs898947076	121	P>L		No	ClinGen gnomAD
rs748513171 CA8612037	123	H>P		No	ClinGen ExAC TOPMed gnomAD
rs772356897 CA8612038	123	H>Q		No	ClinGen ExAC
rs564812671 CA399858778	124	D>A		No	ClinGen 1000Genomes
rs564812671 CA291016219	124	D>G		No	ClinGen 1000Genomes
CA8612040 rs202151146	125	S>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8612043 rs759674454	126	E>G		No	ClinGen ExAC gnomAD
CA8612042 rs776691576	126	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1305275030 CA399858811	129	K>M		No	ClinGen gnomAD
CA8612044 rs765202046	129	K>N		No	ClinGen ExAC TOPMed gnomAD
rs752620066 CA399858815	130	L>V		No	ClinGen ExAC TOPMed gnomAD
CA399858818 rs1598115635	130	L>W		No	ClinGen Ensembl
rs1246796223 CA399858827	132	A>T		No	ClinGen TOPMed
rs894323965 CA291016292	132	A>V		No	ClinGen Ensembl
CA291016306 rs763269543	134	A>T		No	ClinGen Ensembl
rs1283821897 CA399858842	134	A>V		No	ClinGen gnomAD
CA399858845 rs1207364761	135	A>S		No	ClinGen gnomAD
CA8612048 rs763806684	136	G>E		No	ClinGen ExAC
CA291016351 rs763806684	136	G>V		No	ClinGen ExAC
CA291016360 rs573692319	138	E>K		No	ClinGen TOPMed gnomAD
CA399858859 rs573692319	138	E>Q		No	ClinGen TOPMed gnomAD
rs1391342239 CA399858868	139	E>K		No	ClinGen TOPMed
CA399858883 rs1598115647	141	W>R		No	ClinGen Ensembl
CA399858892 rs1442822402	142	G>R		No	ClinGen gnomAD
CA8612049 rs751186893	142	G>V		No	ClinGen ExAC gnomAD
CA8612050 rs756961690	146	R>K		No	ClinGen ExAC gnomAD
CA8612051 rs756961690	146	R>T		No	ClinGen ExAC gnomAD
rs1168673902 CA399858930	147	Q>L		No	ClinGen gnomAD
CA399858936 rs1310202424	148	L>R		No	ClinGen TOPMed
rs745348258 CA8612052	148	L>V		No	ClinGen ExAC gnomAD
CA8612053 rs755618582	149	G>R		No	ClinGen ExAC TOPMed gnomAD
CA291016406 rs1024230967	149	G>V		No	ClinGen Ensembl
rs1163903505 CA399858953	151	K>R		No	ClinGen TOPMed
rs1567917922 CA399858970	153	H>R		No	ClinGen Ensembl
rs998890294 CA291016430	159	K>Q		No	ClinGen Ensembl
CA399859020 rs1419632893	161	K>Q		No	ClinGen TOPMed
rs1380848991 CA399859035	163	H>Y		No	ClinGen gnomAD
CA8612059 rs747440430	169	K>R		No	ClinGen ExAC TOPMed gnomAD
CA8612065 rs762800485	178	F>C		No	ClinGen ExAC TOPMed gnomAD
rs1168879110 CA399859183	182	Q>R		No	ClinGen gnomAD
CA291016503 rs997548764	184	L>F		No	ClinGen TOPMed gnomAD
CA399859229 rs1222065251	189	I>M		No	ClinGen TOPMed
CA8612069 rs142819745	193	M>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8612070 rs530470552	194	F>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1380620464 CA399859282	197	G>A		No	ClinGen gnomAD
CA291016544 rs866763268	199	P>Q		No	ClinGen Ensembl
rs1388175038 CA399859299	200	V>I		No	ClinGen TOPMed
rs778315232 CA8612075	203	Y>C		No	ClinGen ExAC gnomAD
rs1267115653 CA399859397	214	D>N		No	ClinGen gnomAD
rs908824824 CA291016603	216	E>G		No	ClinGen TOPMed
rs771328485 CA8612077	216	E>K		No	ClinGen ExAC gnomAD
CA291016605 rs17845094	219	D>H		No	ClinGen Ensembl
CA291016612 rs17845094	219	D>Y		No	ClinGen Ensembl
CA399859458 rs1459162610	222	T>I		No	ClinGen TOPMed gnomAD
rs552016551 CA291016624	223	G>C		No	ClinGen TOPMed
rs552016551 CA291016622	223	G>S		No	ClinGen TOPMed
rs1451987103 CA399859464	224	L>V		No	ClinGen gnomAD
CA399859478 rs1429765117	226	S>P		No	ClinGen TOPMed
CA399859490 rs1404212859	228	R>G		No	ClinGen gnomAD
rs1435093631 CA399859503	230	A>S		No	ClinGen TOPMed
rs774469216 CA8612085	233	S>C		No	ClinGen ExAC TOPMed gnomAD
rs774469216 CA291016633	233	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1319471293 CA399859525	234	D>N		No	ClinGen Ensembl
CA399859546 rs1270508067	236	T>I		No	ClinGen TOPMed
rs761658949 CA8612086	240	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1598115801 CA399859590	242	M>T		No	ClinGen Ensembl
CA399859616 rs1284362154	245	G>A		No	ClinGen TOPMed
rs1323219016 CA399859611	245	G>R		No	ClinGen TOPMed
rs1284362154 CA399859615	245	G>V		No	ClinGen TOPMed
rs536863589 CA291016673	246	G>R		No	ClinGen 1000Genomes
rs930368194 CA291016676	247	E>K		No	ClinGen Ensembl
rs199709995 CA8612089	248	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs766123446 CA8612090	248	E>D		No	ClinGen ExAC gnomAD
rs1267342278 CA399859629	248	E>K		No	ClinGen gnomAD
CA8612093 rs778225514	251	G>V		No	ClinGen ExAC
rs781539082 CA8612096	254	G>A		No	ClinGen ExAC gnomAD
rs746307675 CA8612097	255	M>I		No	ClinGen ExAC gnomAD
rs1473892250 CA399859685	256	G>E		No	ClinGen gnomAD
CA291016724 rs77347587	256	G>R		No	ClinGen 1000Genomes
CA399859711 rs1469256984	260	S>N		No	ClinGen TOPMed
rs749295351 CA8612101	269	E>K		No	ClinGen ExAC gnomAD
CA291016786 rs556337511	276	T>M		No	ClinGen ExAC gnomAD
CA8612102 rs556337511	276	T>R		No	ClinGen ExAC gnomAD
CA8612105 rs771927060	285	Q>R		No	ClinGen ExAC gnomAD
CA399859911 rs1312995284	288	I>L		No	ClinGen gnomAD
CA399859915 rs1598115865	288	I>M		No	ClinGen Ensembl
CA399859910 rs1312995284	288	I>V		No	ClinGen gnomAD
CA399859969 rs1243121610	296	K>T		No	ClinGen gnomAD
CA8612109 rs753570394	304	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1232619623 CA399860040	306	N>H		No	ClinGen gnomAD
rs1232619623 CA399860042	306	N>Y		No	ClinGen gnomAD
CA399860054 rs1190663893	308	L>M		No	ClinGen TOPMed gnomAD
CA399860090 rs1328105652	313	K>N		No	ClinGen TOPMed gnomAD
CA399860088 rs1598115894	313	K>R		No	ClinGen Ensembl
rs577043303 CA8612115	314	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1451337883 CA399860102	316	G>R		No	ClinGen TOPMed
CA399860107 rs1449979802	317	G>S		No	ClinGen gnomAD
CA399860116 rs1598115906	318	D>G		No	ClinGen Ensembl
rs780098711 CA8612118	318	D>N		No	ClinGen ExAC gnomAD
CA399860120 rs1429662127	319	D>N		No	ClinGen gnomAD
rs749545313 CA8612119	320	A>T		No	ClinGen ExAC gnomAD
CA399860136 rs1167511541	321	R>H		No	ClinGen TOPMed
CA399860140 rs1215631440	322	V>M		No	ClinGen TOPMed gnomAD
rs1306322141 CA399860156	324	E>D		No	ClinGen TOPMed gnomAD
rs755049061 CA8612120	327	L>V		No	ClinGen ExAC TOPMed gnomAD
CA8612122 rs748306481	330	D>E		No	ClinGen ExAC TOPMed gnomAD
CA399860202 rs1250294114	332	L>Q		No	ClinGen TOPMed
CA399860200 rs1181994252	332	L>V		No	ClinGen gnomAD
rs1343823870 CA399860215	334	A>V		No	ClinGen TOPMed
CA291016903 rs1047809248	335	E>D		No	ClinGen TOPMed
CA8612125 rs773251342	337	L>F		No	ClinGen ExAC gnomAD
CA8612128 rs541011575	341	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399860260 rs1334912340	342	E>K		No	ClinGen TOPMed
CA8612130 rs776102182	343	N>K		No	ClinGen ExAC TOPMed gnomAD
CA399860275 COSM356845 rs1217172915	344	E>K	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
rs368302641 CA8612131	347	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs774964207 CA8612132	347	R>Q		No	ClinGen ExAC gnomAD
rs368302641 CA291016923	347	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA8612135 rs750970888	349	Q>E		No	ClinGen ExAC gnomAD
rs1598115979 CA399860309	349	Q>R		No	ClinGen Ensembl
rs1264081938 CA399860322	351	R>*		No	ClinGen gnomAD
rs756384069 CA399860323	351	R>P		No	ClinGen ExAC TOPMed gnomAD
rs756384069 CA8612136	351	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs762293916 CA8612138	352	A>P		No	ClinGen ExAC TOPMed gnomAD
rs201459082 CA8612140	353	P>L		No	ClinGen 1000Genomes ExAC
CA8612141 rs201018268	356	K>N		No	ClinGen 1000Genomes ExAC gnomAD
CA399860350 rs1240497147	356	K>T		No	ClinGen gnomAD
rs1567918222 CA399860358	357	F>S		No	ClinGen Ensembl
CA399860366 rs1191712738	358	G>A		No	ClinGen gnomAD
rs755970749 CA8612142	360	D>D		No	ClinGen ExAC
CA8612143 rs758595649	360	D>E		No	ClinGen ExAC gnomAD

No associated diseases with O94992

No regional properties for O94992

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O94992

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Binds alpha-importin and is mostly nuclear (PubMed:16362050)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
7SK snRNP	A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name	Definition
7SK snRNA binding	Binding to a 7SK small nuclear RNA (7SK snRNA).
cyclin-dependent protein serine/threonine kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.
identical protein binding	Binding to an identical protein or proteins.
P-TEFb complex binding	Binding to a P-TEFb complex.
protein kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
snRNA binding	Binding to a small nuclear RNA (snRNA).

9 GO annotations of biological process

Name	Definition
activation of innate immune response	Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transcription elongation from RNA polymerase II promoter	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
negative regulation of transcription, DNA-templated	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of viral transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription.
positive regulation of signal transduction by p53 class mediator	Any process that activates or increases the frequency, rate or extent of signal transduction by p53 class mediator.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0X0C4	HEXIM1	Protein HEXIM1	Bos taurus (Bovine)	PR
Q96MH2	HEXIM2	Protein HEXIM2	Homo sapiens (Human)	PR

10	20	30	40	50	60
MAEPFLSEYQ	HQPQTSNCTG	AAAVQEELNP	ERPPGAEERV	PEEDSRWQSR	AFPQLGGRPG
70	80	90	100	110	120
PEGEGSLESQ	PPPLQTQACP	ESSCLREGEK	GQNGDDSSAG	GDFPPPAEVE	PTPEAELLAQ
130	140	150	160	170	180
PCHDSEASKL	GAPAAGGEEE	WGQQQRQLGK	KKHRRRPSKK	KRHWKPYYKL	TWEEKKKFDE
190	200	210	220	230	240
KQSLRASRIR	AEMFAKGQPV	APYNTTQFLM	DDHDQEEPDL	KTGLYSKRAA	AKSDDTSDDD
250	260	270	280	290	300
FMEEGGEEDG	GSDGMGGDGS	EFLQRDFSET	YERYHTESLQ	NMSKQELIKE	YLELEKCLSR
310	320	330	340	350
MEDENNRLRL	ESKRLGGDDA	RVRELELELD	RLRAENLQLL	TENELHRQQE	RAPLSKFGD