Q0WVE8
PR
Gene name |
RRP6L1 |
Protein name |
Protein RRP6-like 1 |
Names |
AtRRP6L1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G54440 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0WVE8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0WVE8-F1 | Predicted | AlphaFoldDB |
72 variants for Q0WVE8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_20323288_G_T,GA | 2 | R>I | No | 1000Genomes | |
| ENSVATH14315295 | 17 | E>V | No | 1000Genomes | |
| tmp_1_20323363_A_T | 27 | K>I | No | 1000Genomes | |
| ENSVATH13568893 | 32 | D>E | No | 1000Genomes | |
| ENSVATH13568894 | 33 | K>T | No | 1000Genomes | |
| ENSVATH13568905 | 34 | G>R | No | 1000Genomes | |
| ENSVATH04960694 | 39 | G>C | No | 1000Genomes | |
| tmp_1_20323425_C_T | 48 | P>S | No | 1000Genomes | |
| tmp_1_20323438_A_C | 52 | K>T | No | 1000Genomes | |
| tmp_1_20323451_G_C,T | 56 | E>D | No | 1000Genomes | |
| tmp_1_20323724_G_A | 102 | M>I | No | 1000Genomes | |
| tmp_1_20323751_A_T | 111 | E>D | No | 1000Genomes | |
| ENSVATH01370308 | 128 | A>T | No | 1000Genomes | |
| tmp_1_20323806_G_A | 130 | A>T | No | 1000Genomes | |
| tmp_1_20324105_A_G | 144 | N>S | No | 1000Genomes | |
| ENSVATH13568917 | 162 | T>A | No | 1000Genomes | |
| ENSVATH13568918 | 175 | H>R | No | 1000Genomes | |
| tmp_1_20324237_A_T | 188 | K>I | No | 1000Genomes | |
| ENSVATH13568920 | 190 | K>N | No | 1000Genomes | |
| ENSVATH04960703 | 242 | A>V | No | 1000Genomes | |
| ENSVATH04960706 | 254 | I>R | No | 1000Genomes | |
| ENSVATH13568940 | 285 | T>R | No | 1000Genomes | |
| ENSVATH00097549 | 290 | D>Y | No | 1000Genomes | |
| ENSVATH13568941 | 292 | Q>K | No | 1000Genomes | |
| tmp_1_20325126_A_G | 292 | Q>R | No | 1000Genomes | |
| tmp_1_20325602_A_T | 301 | Y>F | No | 1000Genomes | |
| tmp_1_20325607_C_T | 303 | R>C | No | 1000Genomes | |
| ENSVATH13568961 | 316 | L>V | No | 1000Genomes | |
| tmp_1_20325650_G_C | 317 | W>S | No | 1000Genomes | |
| ENSVATH13568962 | 318 | T>N | No | 1000Genomes | |
| tmp_1_20325670_C_A | 324 | H>N | No | 1000Genomes | |
| tmp_1_20325888_G_A | 328 | V>I | No | 1000Genomes | |
| ENSVATH04960721 | 330 | T>I | No | 1000Genomes | |
| ENSVATH13568968 | 350 | R>Q | No | 1000Genomes | |
| ENSVATH13568970 | 367 | T>I | No | 1000Genomes | |
| ENSVATH13568971 | 375 | M>I | No | 1000Genomes | |
| ENSVATH04960724 | 380 | A>G | No | 1000Genomes | |
| ENSVATH04960724 | 380 | A>V | No | 1000Genomes | |
| ENSVATH13568972 | 384 | R>H | No | 1000Genomes | |
| ENSVATH13568973 | 403 | V>I | No | 1000Genomes | |
| ENSVATH14315331 | 406 | R>Q | No | 1000Genomes | |
| ENSVATH13569005 | 432 | M>T | No | 1000Genomes | |
| ENSVATH04960733 | 436 | P>R | No | 1000Genomes | |
| ENSVATH14315333 | 441 | T>I | No | 1000Genomes | |
| tmp_1_20326841_C_A | 443 | T>K | No | 1000Genomes | |
| ENSVATH04960734 | 448 | S>C | No | 1000Genomes | |
| tmp_1_20326927_T_G | 472 | L>V | No | 1000Genomes | |
| ENSVATH01370315 | 477 | E>K | No | 1000Genomes | |
| ENSVATH13569008 | 481 | T>K | No | 1000Genomes | |
| ENSVATH00097551 | 486 | N>S | No | 1000Genomes | |
| ENSVATH14315355 | 487 | I>F | No | 1000Genomes | |
| ENSVATH13569020 | 506 | K>N | No | 1000Genomes | |
| tmp_1_20327495_A_T | 527 | R>W | No | 1000Genomes | |
| ENSVATH13569021 | 529 | F>V | No | 1000Genomes | |
| tmp_1_20327505_A_G | 530 | E>G | No | 1000Genomes | |
| ENSVATH14315356 | 532 | D>H | No | 1000Genomes | |
| ENSVATH04960740 | 544 | S>C | No | 1000Genomes | |
| ENSVATH13569023 | 545 | K>T | No | 1000Genomes | |
| ENSVATH04960741 | 565 | Y>C | No | 1000Genomes | |
| ENSVATH04960742 | 567 | Q>E | No | 1000Genomes | |
| ENSVATH13569025 | 570 | K>E | No | 1000Genomes | |
| ENSVATH13569027 | 572 | A>D | No | 1000Genomes | |
| ENSVATH13569026 | 572 | A>P | No | 1000Genomes | |
| tmp_1_20327759_C_T | 581 | T>M | No | 1000Genomes | |
| ENSVATH13569028 | 583 | S>L | No | 1000Genomes | |
| tmp_1_20327795_C_T | 593 | P>L | No | 1000Genomes | |
| tmp_1_20327810_C_T | 598 | T>I | No | 1000Genomes | |
| ENSVATH13569029 | 608 | D>E | No | 1000Genomes | |
| ENSVATH04960743 | 608 | D>G | No | 1000Genomes | |
| ENSVATH04960743 | 608 | D>V | No | 1000Genomes | |
| ENSVATH04960744 | 616 | D>E | No | 1000Genomes | |
| ENSVATH13569033 | 624 | H>P | No | 1000Genomes |
No associated diseases with Q0WVE8
1 regional properties for Q0WVE8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Exocyst complex component Sec8, N-terminal | 45 - 143 | IPR007191 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| single-stranded RNA binding | Binding to single-stranded RNA. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| gene silencing by RNA-directed DNA methylation | A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism. |
| histone mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). |
| nuclear polyadenylation-dependent antisense transcript catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript. |
| nuclear polyadenylation-dependent CUT catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT. |
| nuclear polyadenylation-dependent rRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. |
| nuclear polyadenylation-dependent snoRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA. |
| nuclear polyadenylation-dependent snRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA. |
| nuclear polyadenylation-dependent tRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA. |
| polyadenylation-dependent snoRNA 3'-end processing | Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. |
| positive regulation of histone H3-K27 trimethylation | Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRFDDPMDEF | KRNRKMEEDS | KKVIDVKVAE | SDKGFAKFGK | AEVPFHIPTL | TKPQEEYKIL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VDNANNPFEH | VLLEKSEDGL | RFIHPLEELS | VMDFVDRNLS | EMRPVKPLPL | EETPFKLVEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKDLEDLAAA | LQSVEEFAVD | LEHNQYRTFQ | GLTCLMQIST | RTEDYIVDIF | KLWDHIGPYL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RELFKDPKKK | KVIHGADRDI | IWLQRDFGIY | VCNLFDTGQA | SRVLKLERNS | LEFLLKHYCG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VAANKEYQKA | DWRIRPLPDV | MKRYAREDTH | YLLYIYDVMR | MELHTMAKED | EQSDSPLVEV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKRSYDVCMQ | LYEKELWTRD | SYLHVYGVQT | GNLNAVQLSI | VAGLCEWRDR | IARADDESTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YVLPNKTLFD | IAKEMPIVVA | QLRRLLKSKL | PYLERNFDAV | ISVIRRSMQN | AAAFEPVVQS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKDRRPETVV | EMNIEPKIEK | TDTGASASSL | SLEKVCVDDS | KKQSSGFGVL | PLKRKLESDK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TVVEKNIEPK | IEKTGTEASA | SSLSSKKVCV | DDSKKQSSGF | GVLLSKRKFE | SDNKVKEEVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VSKSKPDKVI | IVVDDDDDDD | DDESYEQSTK | AADALDRVSE | TPSKGSPSLT | QKPKTCNTEV |
| 610 | 620 | 630 | |||
| IVLDDDDDSE | SREDEDMRRR | SEKHRRFMNM | KRGFLNI |