P56960
PR
Gene name |
Exosc10 (Pmscl2) |
Protein name |
Exosome component 10 |
Names |
Autoantigen PM/Scl 2 homolog, Polymyositis/scleroderma autoantigen 2 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:50912 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P56960
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P56960-F1 | Predicted | AlphaFoldDB |
54 variants for P56960
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388732339 | 24 | M>V | No | EVA | |
| rs3395127126 | 47 | T>P | No | EVA | |
| rs3394908554 | 69 | F>C | No | EVA | |
| rs3395076597 | 69 | F>L | No | EVA | |
| rs3395024394 | 70 | Q>K | No | EVA | |
| rs3388730546 | 89 | Q>E | No | EVA | |
| rs3388734882 | 97 | I>L | No | EVA | |
| rs3388734460 | 133 | G>A | No | EVA | |
| rs3388734460 | 133 | G>D | No | EVA | |
| rs3388734735 | 140 | P>H | No | EVA | |
| rs3388730539 | 156 | W>* | No | EVA | |
| rs3388734738 | 165 | K>N | No | EVA | |
| rs3388720060 | 183 | P>S | No | EVA | |
| rs3388739057 | 200 | P>Q | No | EVA | |
| rs3388718322 | 213 | P>R | No | EVA | |
| rs3388727527 | 250 | E>* | No | EVA | |
| rs3388724364 | 252 | D>N | No | EVA | |
| rs3388730697 | 256 | H>Q | No | EVA | |
| rs3388727521 | 283 | V>E | No | EVA | |
| rs3388719987 | 284 | G>V | No | EVA | |
| rs3388724441 | 320 | R>* | No | EVA | |
| rs3388720065 | 328 | L>I | No | EVA | |
| rs3388724365 | 330 | Q>* | No | EVA | |
| rs3388727540 | 343 | L>R | No | EVA | |
| rs3388734671 | 344 | E>D | No | EVA | |
| rs3388727533 | 344 | E>K | No | EVA | |
| rs3388734450 | 346 | R>H | No | EVA | |
| rs3388732376 | 359 | P>T | No | EVA | |
| rs3388734375 | 413 | V>L | No | EVA | |
| rs3388730573 | 414 | E>K | No | EVA | |
| rs3395076580 | 421 | L>P | No | EVA | |
| rs3394781801 | 424 | W>* | No | EVA | |
| rs3395076627 | 430 | P>A | No | EVA | |
| rs3394781777 | 443 | Y>H | No | EVA | |
| rs3388730586 | 458 | R>K | No | EVA | |
| rs3395024378 | 508 | T>N | No | EVA | |
| rs3395215403 | 510 | F>V | No | EVA | |
| rs3394781804 | 514 | F>L | No | EVA | |
| rs3388734366 | 523 | R>G | No | EVA | |
| rs3388730543 | 555 | C>* | No | EVA | |
| rs3388731582 | 562 | V>F | No | EVA | |
| rs3388734928 | 577 | R>* | No | EVA | |
| rs3388730696 | 603 | E>V | No | EVA | |
| rs3388738108 | 606 | L>R | No | EVA | |
| rs3388731598 | 615 | A>G | No | EVA | |
| rs3388727144 | 653 | L>I | No | EVA | |
| rs3388734751 | 656 | A>G | No | EVA | |
| rs3395069904 | 694 | M>L | No | EVA | |
| rs3388718314 | 777 | N>H | No | EVA | |
| rs3395124462 | 792 | I>V | No | EVA | |
| rs3388730513 | 803 | S>G | No | EVA | |
| rs3388734655 | 814 | G>W | No | EVA | |
| rs3388730501 | 835 | K>N | No | EVA | |
| rs3394972227 | 860 | C>F | No | EVA |
No associated diseases with P56960
Functions
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| euchromatin | A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. |
| exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| nuclear exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| nucleolar exosome (RNase complex) | A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. |
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| single-stranded RNA binding | Binding to single-stranded RNA. |
19 GO annotations of biological process
| Name | Definition |
|---|---|
| CUT catabolic process | The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs). |
| dosage compensation by inactivation of X chromosome | Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. |
| exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. |
| histone mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). |
| maturation of 5.8S rRNA | Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. |
| negative regulation of telomere maintenance via telomerase | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase. |
| nuclear mRNA surveillance | A process that identifies and degrades defective or aberrant mRNAs within the nucleus. |
| nuclear polyadenylation-dependent antisense transcript catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript. |
| nuclear polyadenylation-dependent CUT catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT. |
| nuclear polyadenylation-dependent rRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. |
| nuclear polyadenylation-dependent snoRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA. |
| nuclear polyadenylation-dependent snRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA. |
| nuclear polyadenylation-dependent tRNA catabolic process | The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA. |
| nuclear-transcribed mRNA catabolic process | The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
| polyadenylation-dependent snoRNA 3'-end processing | Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. |
| regulation of telomerase RNA localization to Cajal body | Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body. |
| RNA catabolic process | The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| RNA processing | Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPPSPREHQ | SAPATSATKP | DAEMVLPGFP | DADSFVKFAL | GSVVAVTKAS | GGLPQFGDEY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DFYRSFPAFQ | AFCETQGDRL | LQCMSRVMQY | HGCRSNIKDR | SKVTELEDKF | DLLVDTNDVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LERVGMLLDE | ASGVNKHQQP | VLPAGLQVPK | TIVSSWNRKA | GEYGKKAKSE | TFRLLHAKNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VRPQLRFREK | IDNSNTPFLP | KIFVKPNARK | PLPLALSKER | RERPQDRPED | LDVPPALADF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IHQQRTQQVE | QDMFAHPYQY | ELDHFTPPQS | VLQRPKPQLY | RAVGETPCHL | VSSLDELVEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NEKLLGCQEF | AVDLEHHSYR | SFLGLTCLMQ | ISTRTEDFIV | DTLELRSDMY | ILNESLTDPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IVKVFHGADS | DIEWLQKDFG | LYVVNMFDTH | QAARLLNLAR | HSLDHLLRLY | CGVESNKQYQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LADWRIRPLP | EEMLSYARDD | THYLLYIYDR | MRLELWERGN | HQPVQLQVVW | QRSRDICLKK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FVKPIFTDES | YLELYRKQKK | HLNSQQLTAF | QLLFAWRDKT | ARREDESYGY | VLPNHMMLKI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AEELPKEPQG | IIACCNPVPP | LVRQQINEMH | LLIQQAREMP | LLKSENAAGV | RKSGPLPSAE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RLENDLFGPH | DCSHAPPDNY | QNTSTDGTLP | LQKQPSLFTE | GKEETSVDAG | CLLATAVITL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FSEPNTEEGG | KTPLTVAQKK | AQNIMQSFEN | PFRMFLPSLE | HKAHISQAAK | FDPSSKIYEI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SNRWKLASQV | QVQKEPKEAT | KKKVAEQTAA | REEAKEEAAA | GVLEQAIPVR | QQAALENATK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KRERATSDLR | TIEQKQEKKR | LKSSKKAKDP | DPPGKDFSPY | DYSQSDFRAF | AGDSKSKPSS |
| 850 | 860 | 870 | 880 | ||
| QFDPNKLAPS | GKKGVGAKKC | KQSVGNKSMS | FAVGKSDRGF | RHNWPKR |