Q0P543

PR
Gene name
Gipr
Protein name
Gastric inhibitory polypeptide receptor
Names
GIP-R, Glucose-dependent insulinotropic polypeptide receptor
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:381853
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q0P543

Entry ID Method Resolution Chain Position Source
6O9H X-ray 210 A C/D 19-134 PDB
6O9I X-ray 260 A C 19-134 PDB
AF-Q0P543-F1 Predicted AlphaFoldDB

20 variants for Q0P543

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3397677820 4 R>L No EVA
rs3388880338 34 R>H No EVA
rs247538147 121 G>E No EVA
rs31326841 122 A>V No EVA
rs3388880358 139 V>E No EVA
rs3388890221 145 L>Q No EVA
rs3388873702 156 S>I No EVA
rs51203567 194 G>D No EVA
rs3388858785 206 N>D No EVA
rs3388880121 247 S>P No EVA
rs3388886530 253 R>C No EVA
rs3388890212 266 F>I No EVA
rs3388865120 367 F>L No EVA
rs3388867767 391 I>V No EVA
rs212993683 439 V>I No EVA
rs3388880149 447 M>I No EVA
rs3388844182 451 P>S No EVA
rs3388867723 456 L>F No EVA
rs3388867779 458 S>T No EVA
rs3388880341 461 C>W No EVA

No associated diseases with Q0P543

4 regional properties for Q0P543

Type Name Position InterPro Accession
domain GPCR, family 2, extracellular hormone receptor domain 41 - 123 IPR001879
domain GPCR, family 2-like, transmembrane domain 133 - 392 IPR017981
conserved_site GPCR, family 2, secretin-like, conserved site 57 - 81 IPR017983-1
conserved_site GPCR, family 2, secretin-like, conserved site 380 - 395 IPR017983-2

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
G protein-coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
gastric inhibitory peptide receptor activity Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein.
glucagon family peptide binding Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP).
peptide hormone binding Binding to a peptide with hormonal activity in animals.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

14 GO annotations of biological process

Name Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
adenylate cyclase-modulating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
cell surface receptor signaling pathway The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
desensitization of G protein-coupled receptor signaling pathway The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
endocrine pancreas development The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
gastric inhibitory peptide signaling pathway A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
neuropeptide signaling pathway A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
positive regulation of cAMP-mediated signaling Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling.
positive regulation of cytosolic calcium ion concentration Any process that increases the concentration of calcium ions in the cytosol.
positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
response to axon injury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
response to fatty acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P70205 Adcyap1r1 Pituitary adenylate cyclase-activating polypeptide type I receptor Mus musculus (Mouse) PR
10 20 30 40 50 60
MPLRLLLLLL WLWGLQWAET DSEGQTTTGE LYQRWEHYGQ ECQKMLETTE PPSGLACNGS
70 80 90 100 110 120
FDMYACWNYT AANTTARVSC PWYLPWFRQV SAGFVFRQCG SDGQWGSWRD HTQCENPEKN
130 140 150 160 170 180
GAFQDQTLIL ERLQIMYTVG YSLSLTTLLL ALLILSLFRR LHCTRNYIHM NLFTSFMLRA
190 200 210 220 230 240
AAILTRDQLL PPLGPYTGDQ APTPWNQALA ACRTAQIMTQ YCVGANYTWL LVEGVYLHHL
250 260 270 280 290 300
LVIVGRSEKG HFRCYLLLGW GAPALFVIPW VIVRYLRENT QCWERNEVKA IWWIIRTPIL
310 320 330 340 350 360
ITILINFLIF IRILGILVSK LRTRQMRCPD YRLRLARSTL TLVPLLGVHE VVFAPVTEEQ
370 380 390 400 410 420
VEGSLRFAKL AFEIFLSSFQ GFLVSVLYCF INKEVQSEIR QGWRHRRLRL SLQEQRPRPH
430 440 450
QELAPRAVPL SSACREAAVG NALPSGMLHV PGDEVLESYC