Q0P4R5

PR
Gene name
dis3l
Protein name
DIS3-like exonuclease 1
Names
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:780296
EC number
3.1.13.1: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

930-1039 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0P4R5

Entry ID Method Resolution Chain Position Source
AF-Q0P4R5-F1 Predicted AlphaFoldDB

No variants for Q0P4R5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0P4R5

No associated diseases with Q0P4R5

4 regional properties for Q0P4R5

Type Name Position InterPro Accession
domain Ribonuclease II/R 458 - 808 IPR001900
conserved_site Ribonuclease II/R, conserved site 775 - 799 IPR022966
domain Rrp44-like cold shock domain 221 - 309 IPR033771
domain Dis3-like cold-shock domain 2 359 - 426 IPR041505

Functions

Description
EC Number 3.1.13.1 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasmic exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.

2 GO annotations of molecular function

Name Definition
3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
rRNA catabolic process The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P21499 rnr Ribonuclease R Escherichia coli (strain K12) PR
10 20 30 40 50 60
MLKTEKILHL KARGRSVRAV REHYLREDVR CGSALCLTCP RDGKLLSEDL THYVVPDCQI
70 80 90 100 110 120
LQDYLEVLEF PELRGIIIMQ TACQSVQHQR GRRQYKRLCS LLRDTRHDCI LFSNEFQNHA
130 140 150 160 170 180
YLPREMGESA LAWQTRCIYN SCVWYYQHCQ KKIPVVMVTE DKSVIRQYNT ETQEVYVVSF
190 200 210 220 230 240
QIYLETFWPN LKGALELYKS LKETHREREL ESREGNGKEY PEHLPLEILE AGIKSGRYQQ
250 260 270 280 290 300
GVLSVNKHRA QLEGFVRLQG LGGKETDIQS DILIYGTKPR NRAIHGDLVA VELLSRSEWK
310 320 330 340 350 360
GRNGALCENE TDEKAVDAQA EVMPTGRVVG ILQRNWRDYV ATFPAKEDIE TQGKNAQRVL
370 380 390 400 410 420
VMPWDYRIPK IRISTQQAEA LQDYRVVVRI DSWESTSLYP NGHFVRVLGR TGNLEAEIAT
430 440 450 460 470 480
ILVENSISVN PFSEAQLAEM PSNTPESPWQ VKPEEGDRLD LRKTHLVFSI DPKGCEDVDD
490 500 510 520 530 540
ALSIRKLPSG HLELGVHIAD VTHFVPPNTY TDIEARSRAT TYYLADRRYD MLPLILSADL
550 560 570 580 590 600
CSLLGGVDRY AVSVIWEMDS STYEIRRVWY GRTIIRSSYK LSYEVAQQLM DGDLEPLNTE
610 620 630 640 650 660
MELHPLKQDP VRLEQLLWAV GKLTEVAHAT RMRRDMSGAL ELEGVEVRVQ LGEKHSIDDL
670 680 690 700 710 720
VPKQPLQMHE TIAECMILAN HWVAKKIWEC YPQHALLRLH PPARQEFFQE LKECAKARGF
730 740 750 760 770 780
SIDTRSNKAL ADSLDQANDP SDPLVNQLLR MMATQAMSNA RYFSTGSYTE DEFYHYGLAL
790 800 810 820 830 840
EKYTHFTSPI RRYADIVVHR LLLAAVNKGP KDNLLGNKDL EELCRHINVR NRAAQHCQKQ
850 860 870 880 890 900
STELFQCMFF KDKDPDSDQR CISDAVIYGI RTNGVLLFLP RYGIKGAAYL KNIDGLVLAC
910 920 930 940 950 960
KDNGRCHWMP GSLQRLPDRI VVTTQEAKSF SYCLFDHVTV RIHVQSSRFH PDSIRLEIIR
970 980 990 1000 1010 1020
NRPHSSQEAL PSASNPQLAR SELVKEVTRT AVEAQLAVEG AEELKPVEHY QEYRQTQGQS
1030
LYSMLEELWD LALLDVSGA