Q09652
Gene name |
gstk-1 (ZK1320.1) |
Protein name |
Glutathione S-transferase kappa 1 |
Names |
GST class-kappa |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_ZK1320.1 |
EC number |
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q09652
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q09652-F1 | Predicted | AlphaFoldDB |
No variants for Q09652
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q09652 | |||||
No associated diseases with Q09652
1 regional properties for Q09652
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DSBA-like thioredoxin domain | 6 - 210 | IPR001853 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.18 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione peroxidase activity | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glutathione metabolic process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPKLPRIDFY | FDVISPYSYI | AFEVFQKLET | QWKGVTIRYI | PFFLGAVMKE | SGNRPPAMLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARSIMMMTDL | KRTAKFWDIP | LTPPPLFMEW | IKKYRTTGAM | KVLLVLQEQD | KELMLRAARE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MWVRLWSRSE | KIFEDQDFVE | VLKAVGVKNP | EQIVEKSKDE | KYIKILMENT | NKGVDLMAYG |
| 190 | 200 | 210 | 220 | ||
| APWINVHTED | GSEHSFFGSD | RFHLIADLLQ | QPQPLPDRLF | GQKSKL |