P24473
Gene name |
Gstk1 |
Protein name |
Glutathione S-transferase kappa 1 |
Names |
GST 13-13, GST class-kappa, GSTK1-1, rGSTK1, Glutathione S-transferase subunit 13 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:297029 |
EC number |
2.5.1.18: Transferring alkyl or aryl groups, other than methyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P24473
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1R4W | X-ray | 250 A | A/B/C/D | 1-226 | PDB |
| AF-P24473-F1 | Predicted | AlphaFoldDB |
No variants for P24473
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P24473 | |||||
No associated diseases with P24473
1 regional properties for P24473
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DSBA-like thioredoxin domain | 8 - 210 | IPR001853 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.5.1.18 | Transferring alkyl or aryl groups, other than methyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione peroxidase activity | Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. |
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular oxidant detoxification | Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. |
| epithelial cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. |
| glutathione metabolic process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. |
3 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPAPRVLEL | FYDVLSPYSW | LGFEVLCRYQ | HLWNIKLKLR | PALLAGIMKD | SGNQPPAMVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HKGQYILKEI | PLLKQLFQVP | MSVPKDFFGE | HVKKGTVNAM | RFLTAVSMEQ | PEMLEKVSRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LWMRIWSRDE | DITESQNILS | AAEKAGMATA | QAQHLLNKIS | TELVKSKLRE | TTGAACKYGA |
| 190 | 200 | 210 | 220 | ||
| FGLPTTVAHV | DGKTYMLFGS | DRMELLAYLL | GEKWMGPVPP | TLNARL |