Q09637

PR
Gene name
cyn-9 (cyp-9, T27D1.1)
Protein name
Peptidyl-prolyl cis-trans isomerase 9
Names
PPIase 9, Cyclophilin-9, Rotamase 9
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_T27D1.1
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

156-309 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09637

Entry ID Method Resolution Chain Position Source
AF-Q09637-F1 Predicted AlphaFoldDB

No variants for Q09637

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09637

No associated diseases with Q09637

2 regional properties for Q09637

Type Name Position InterPro Accession
domain Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain 8 - 173 IPR002130
conserved_site Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site 57 - 74 IPR020892

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
cyclosporin A binding Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

3 GO annotations of biological process

Name Definition
extracellular matrix organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08752 PPID Peptidyl-prolyl cis-trans isomerase D Homo sapiens (Human) PR
Q9D6D8 Ppil6 Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAAEKRVFLD ISVDENLIGR IEIRLFVEDA PKTCENFRAL CTGEVGMTPN NKARLHYKQN
70 80 90 100 110 120
EFHRIVKKFM IQGGDITEGD GRGGFSIYGR YFDDEKFKLK HSRPYLLSMA NKGPNSNSSQ
130 140 150 160 170 180
FFITTAAAPH CNGKHVVFGE VVKGQNVVDY IDNLAVDDKS KPLAKVLISN CGELVKKKKP
190 200 210 220 230 240
LKTDEELAAA LEEKNNNARD NEIPKCPKSW LYRDDDNEKK HEMRNDKRRE YRSRRSRSRS
250 260 270 280 290 300
HEKNRDYKKE NRGDSSRSQP RRDENGITVR GRGGVRFRRE RSATPEHWRR NAPTKWVHDS
HKHPEEDLV