Q09524

PR
Gene name
tag-124 (E02H1.3)
Protein name
Probable tRNA pseudouridine synthase tag-124
Names
tRNA pseudouridylate synthase, tRNA-uridine isomerase
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_E02H1.3
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q09524

Entry ID Method Resolution Chain Position Source
AF-Q09524-F1 Predicted AlphaFoldDB

No variants for Q09524

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09524

No associated diseases with Q09524

1 regional properties for Q09524

Type Name Position InterPro Accession
domain Death effector domain 24 - 107 IPR001875

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P31115 DEG1 tRNA pseudouridine(38/39) synthase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MGSKRVCPDA NNSVKSKKAK TLDFLAHPRR KIAIQFFYLG WEHDGLVQQP HTQNTVENHI
70 80 90 100 110 120
MQALIKTHLI EDWTKCDFSR CGRTDKGVSA FKQTAAMVVR SLCPGDSGVF WSDSTQEHQK
130 140 150 160 170 180
VDYKASGEEL PYVKMLNGVL PKTIRVFAWA PVAQTFNARF DCNRRTYKYS FAKADLNLEK
190 200 210 220 230 240
MRQGAELLVG EHDFSNFCQI DMNEKRLLQS YVRKVYEVKV EQVSTHPEND MYSMVELTVS
250 260 270 280 290 300
GSGFLWHMIR YIVTILQEIG RENEQPSLIS QLLDLKKYPS RPQYTLASDT PLCLFDCGYK
310 320 330 340 350 360
SEDVEWKVHD YTLKSTVTGL QKTWATYQAR SRMMENMLGE LTGMAEFSSG DANKGLHEFV
370 380 390 400
QDRPIPSNYI RFENRKMCES LESKKEKMAE KKKNGEESSD KL