P31115

PR
Gene name
DEG1 (HRM3, PUS3, YFL001W)
Protein name
tRNA pseudouridine(38/39) synthase
Names
Depressed growth-rate protein DEG1, tRNA pseudouridine synthase 3, tRNA pseudouridylate synthase 3, tRNA-uridine isomerase 3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YFL001W
EC number
5.4.99.45: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P31115

Entry ID Method Resolution Chain Position Source
AF-P31115-F1 Predicted AlphaFoldDB

15 variants for P31115

Variant ID(s) Position Change Description Diseaes Association Provenance
s06-147138 5 I>V No SGRP
s06-147166 14 A>G No SGRP
s06-147168 15 I>V No SGRP
s06-147466 114 Y>F No SGRP
s06-147546 141 D>N No SGRP
s06-147591 156 A>P No SGRP
s06-147636 171 D>N No SGRP
s06-147712 196 D>A No SGRP
s06-147855 244 V>I No SGRP
s06-147981 286 V>I No SGRP
s06-148186 354 T>S No SGRP
s06-148224 367 T>A No SGRP
s06-148313 396 F>L No SGRP
s06-148353 410 V>I No SGRP
s06-148363 413 T>S No SGRP

No associated diseases with P31115

1 regional properties for P31115

Type Name Position InterPro Accession
domain Pseudouridine synthase I, TruA, alpha/beta domain 239 - 346 IPR020097

Functions

Description
EC Number 5.4.99.45 Transferring other groups
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
RNA binding Binding to an RNA molecule or a portion thereof.
tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

2 GO annotations of biological process

Name Definition
mRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.
tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q09524 tag-124 Probable tRNA pseudouridine synthase tag-124 Caenorhabditis elegans PR
10 20 30 40 50 60
MSNFIRRLVG KMKAISTGTN AIVSKKDSIY ANWSKEQLIR RITELENANK PHSEKFQHIE
70 80 90 100 110 120
DNKKRKISQE EVTRSKAKKA PKKFDFSKHN TRFIALRFAY LGWNYNGLAV QKEYTPLPTV
130 140 150 160 170 180
EGTILEAMNK CKLVPSMVLQ DYKFSRCGRT DKGVSAMNQV ISLEVRSNLT DEEQRDPTND
190 200 210 220 230 240
SREIPYVHVL NQLLPDDIRI SAVCLRPPPN FDARFSCVHR HYKYIFNGKN LNIEKMSKAA
250 260 270 280 290 300
SYFVGERDFR NFCKLDGSKQ ITNFKRTIIS SKILPLSETF YCFDLVGSAF LWHQVRCMMA
310 320 330 340 350 360
ILFLVGQSLE VPEIVLRLTD IEKTPQRPVY EMANDIPLLL YDCKFPEMDW QEPTVDDYKA
370 380 390 400 410 420
IKFTTATEAL TLHYELKAAV CNIFKDVLPT ANTNNFSKTI INLGDGRGKV VGTYVKLEDR
430 440
SVMEPVEVVN AKYSKKKNNK NK