AiPD: Autoinhibited Protein Database

Q07817

Gene name	BCL2L1 (BCL2L, BCLX)
Protein name	Bcl-2-like protein 1
Names	Bcl2-L-1, Apoptosis regulator Bcl-X
Species	Homo sapiens (Human)
KEGG Pathway	hsa:598
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-106 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-106 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

104 structures for Q07817

Entry ID	Method	Resolution	Chain	Position	Source
1BXL	NMR	-	A	1-209	PDB
1G5J	NMR	-	A	1-209	PDB
1LXL	NMR	-	A	1-209	PDB
1MAZ	X-ray	220 A	A	1-209	PDB
1R2D	X-ray	195 A	A	1-211	PDB
1R2E	X-ray	210 A	A	1-211	PDB
1R2G	X-ray	270 A	A	1-211	PDB
1R2H	X-ray	220 A	A	1-211	PDB
1R2I	X-ray	200 A	A	1-211	PDB
1YSG	NMR	-	A	1-209	PDB
1YSI	NMR	-	A	1-209	PDB
1YSN	NMR	-	A	1-209	PDB
2B48	X-ray	345 A	A	1-211	PDB
2LP8	NMR	-	A	1-209	PDB
2LPC	NMR	-	A	1-209	PDB
2M03	NMR	-	A	1-209	PDB
2M04	NMR	-	A	1-209	PDB
2ME8	NMR	-	A	1-209	PDB
2ME9	NMR	-	A	1-209	PDB
2MEJ	NMR	-	A	1-209	PDB
2O1Y	NMR	-	A	1-209	PDB
2O2M	NMR	-			PDB
2O2N	NMR	-			PDB
2P1L	X-ray	250 A	A/C/E/G	1-209	PDB
2PON	NMR	-	B	1-196	PDB
2YJ1	X-ray	224 A	A/C	1-209	PDB
2YQ6	X-ray	180 A	A	1-209	PDB
2YQ7	X-ray	190 A	A	1-209	PDB
2YXJ	X-ray	220 A	A/B	1-209	PDB
3CVA	X-ray	270 A	X	1-211	PDB
3FDL	X-ray	178 A	A	1-209	PDB
3FDM	X-ray	226 A	A/B/C	1-209	PDB
3INQ	X-ray	200 A	A/B	1-209	PDB
3IO8	X-ray	230 A	A/C	1-209	PDB
3PL7	X-ray	261 A	A/B	1-209	PDB
3QKD	X-ray	202 A	A/B	1-209	PDB
3R85	X-ray	195 A	A/B/C/D	1-197	PDB
3SP7	X-ray	140 A	A	1-209	PDB
3SPF	X-ray	170 A	A	1-209	PDB
3WIZ	X-ray	245 A	A/B	1-209	PDB
3ZK6	X-ray	248 A	A/B	1-209	PDB
3ZLN	X-ray	229 A	A	1-209	PDB
3ZLO	X-ray	260 A	A	1-209	PDB
3ZLR	X-ray	203 A	A/B	1-209	PDB
4A1U	X-ray	154 A	A	1-209	PDB
4A1W	X-ray	250 A	A/B/C/D	1-209	PDB
4AQ3	X-ray	240 A	A/B/C/D/E/F	29-44	PDB
4BPK	X-ray	176 A	A/B	1-209	PDB
4C52	X-ray	205 A	A/B	1-209	PDB
4C5D	X-ray	230 A	A/B	1-209	PDB
4CIN	X-ray	269 A			PDB
4EHR	X-ray	209 A	A	1-209	PDB
4HNJ	X-ray	290 A	A/B	1-209	PDB
4IEH	X-ray	210 A	A	29-44	PDB
4PPI	X-ray	285 A	A	1-209	PDB
4QVE	X-ray	205 A	A	1-209	PDB
4QVF	X-ray	153 A	A	1-209	PDB
4QVX	X-ray	210 A			PDB
4TUH	X-ray	180 A	A/B/C/D/E/F/G/H	1-209	PDB
4Z9V	X-ray	210 A	A/B	1-208	PDB
5AGW	X-ray	269 A	A/B	29-44	PDB
5AGX	X-ray	224 A	A/B	29-44	PDB
5B1Z	X-ray	215 A	A/B	1-209	PDB
5C3G	X-ray	245 A	A	83-209	PDB
5FMJ	X-ray	243 A	A	1-209	PDB
5FMK	X-ray	173 A	A	1-209	PDB
5VAY	X-ray	180 A	A/B/C/D	29-44	PDB
5VX3	X-ray	195 A	A/C/E/G	1-209	PDB
6BF2	NMR	-	A	1-209	PDB
6DCN	X-ray	244 A			PDB
6DCO	X-ray	220 A			PDB
6F46	NMR	-	A	202-233	PDB
6HJL	X-ray	220 A			PDB
6IJQ	NMR	-	B	1-209	PDB
6LHD	X-ray	250 A	A/B	2-201	PDB
6O0K	X-ray	162 A	A	29-44	PDB
6O0L	X-ray	220 A	A/C	29-44	PDB
6O0M	X-ray	175 A	A	29-44	PDB
6O0O	X-ray	200 A	A/C	29-44	PDB
6O0P	X-ray	180 A	A	29-44	PDB
6RNU	X-ray	240 A	A/B	1-209	PDB
6ST2	X-ray	179 A	A/B	1-209	PDB
6UVC	X-ray	190 A	A/B	1-209	PDB
6UVD	X-ray	215 A	A/B	1-209	PDB
6UVE	X-ray	287 A	A/B/C	1-209	PDB
6UVF	X-ray	224 A	A/B/C/D/E/F/G/H/I/J/K/L	1-209	PDB
6UVG	X-ray	210 A	A/B/C/D/E/F/G/H/I/J/K/L	1-209	PDB
6UVH	X-ray	219 A	A/B/C/D	1-209	PDB
6VWC	X-ray	160 A			PDB
6X7I	Other	-	A	206-233	PDB
6YLI	X-ray	190 A	A/C	1-209	PDB
6ZHC	X-ray	192 A	DDD	1-209	PDB
7CA4	X-ray	270 A	A	1-211	PDB
7JGV	X-ray	205 A	A/B	1-209	PDB
7JGW	X-ray	130 A	A	1-209	PDB
7LH7	X-ray	141 A			PDB
7XGF	X-ray	190 A	B/C/E/F	1-209	PDB
7XGG	X-ray	190 A	B/C/E/F	1-209	PDB
7Y8D	X-ray	200 A	A	1-196	PDB
7YAA	X-ray	140 A	A	1-196	PDB
8IQK	X-ray	288 A	A/C/E/G	1-209	PDB
8IQL	X-ray	296 A	A/C	29-44	PDB
8U27	NMR	-	A	29-44	PDB
AF-Q07817-F1	Predicted				AlphaFoldDB

140 variants for Q07817

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs373119323 CA9802142	6	R>G		No	ClinGen ESP ExAC gnomAD
CA408580302 rs148274815	6	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9802140 rs148274815	6	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9802141 rs373119323	6	R>W		No	ClinGen ESP ExAC gnomAD
rs1320914743 CA408580300	7	E>K		No	ClinGen gnomAD
CA9802139 rs752292810	10	V>I		No	ClinGen ExAC gnomAD
rs759603556 CA9802137	15	Y>H		No	ClinGen ExAC gnomAD
CA408580221 rs1272422177	16	K>R		No	ClinGen gnomAD
rs1296172344 CA408580153	22	Y>C		No	ClinGen TOPMed
rs753681012 CA9802136	28	S>R		No	ClinGen ExAC gnomAD
rs1293982067 CA408580079	29	D>E		No	ClinGen gnomAD
CA408580091 rs1325938235	29	D>N		No	ClinGen gnomAD
rs760750448 CA9802134	32	E>D		No	ClinGen ExAC TOPMed gnomAD
CA9802135 rs766199813	32	E>G		No	ClinGen ExAC gnomAD
TCGA novel	32	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9802133 rs773505559	34	R>K		No	ClinGen ExAC TOPMed
CA408580020 rs773505559	34	R>T		No	ClinGen ExAC TOPMed
CA408579980 rs1175487979	37	A>D		No	ClinGen gnomAD
TCGA novel	37	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1410318896 CA408579974	38	P>A		No	ClinGen TOPMed gnomAD
CA408579967 rs1379893911	39	E>K		No	ClinGen Ensembl
rs769141052 CA9802128	40	G>E		No	ClinGen ExAC TOPMed gnomAD
rs774465563 CA9802129	40	G>R		No	ClinGen ExAC TOPMed gnomAD
rs145910874 CA9802127	43	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs770213331 CA9802125	44	E>D		No	ClinGen ExAC gnomAD
CA408579830 rs1600328561	47	T>P		No	ClinGen Ensembl
rs376431497 CA9802124	48	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA408579740 rs1213362070	51	I>N		No	ClinGen gnomAD
rs777448557 CA9802123	51	I>V		No	ClinGen ExAC gnomAD
rs1187252281 CA408579718	52	N>S		No	ClinGen TOPMed
rs1339243134 CA408579703	53	G>C		No	ClinGen gnomAD
CA9802122 rs758032919	53	G>D		No	ClinGen ExAC TOPMed gnomAD
CA314081117 rs980933909	54	N>S		No	ClinGen Ensembl
CA9802121 rs752239780	55	P>S		No	ClinGen ExAC gnomAD
rs1600328358 CA408579614	58	H>P		No	ClinGen Ensembl
rs918140042 CA314081115	58	H>Q		No	ClinGen TOPMed
rs778631817 CA9802120	59	L>R		No	ClinGen ExAC TOPMed gnomAD
CA408579599 rs1380940068	59	L>V		No	ClinGen TOPMed gnomAD
CA9802119 rs754896628	60	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1168000429 CA408579576	61	D>E		No	ClinGen gnomAD
rs753840929 CA9802118	61	D>G		No	ClinGen ExAC gnomAD
rs766040914 CA9802117	62	S>G		No	ClinGen ExAC gnomAD
CA408579557 rs1385752892	62	S>R		No	ClinGen gnomAD
rs11550473 CA9802115	64	A>T		No	ClinGen ExAC gnomAD
TCGA novel	64	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774413044 CA9802112	65	V>M		No	ClinGen ExAC gnomAD
CA9802111 rs764167805	66	N>I		No	ClinGen ExAC TOPMed gnomAD
rs1600328082 CA408579478	66	N>K		No	ClinGen Ensembl
CA9802110 rs763397770	67	G>V		No	ClinGen ExAC gnomAD
CA9802109 rs776091690	69	T>I		No	ClinGen ExAC gnomAD
rs1568907558 CA408579429	70	G>D		No	ClinGen Ensembl
CA314081114 rs1021301074	72	S>R		No	ClinGen TOPMed
CA9802108 rs138364013	76	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs746218159 CA9802107	77	A>T		No	ClinGen ExAC gnomAD
rs776915418 CA9802106	77	A>V		No	ClinGen ExAC gnomAD
rs747807022 CA9802104	78	R>P		No	ClinGen ExAC gnomAD
rs747807022 CA314081113	78	R>Q		No	ClinGen ExAC gnomAD
CA9802105 rs374460634	78	R>W		No	ClinGen ESP ExAC gnomAD
rs1375774824 CA408579298	79	E>Q		No	ClinGen gnomAD
CA408579290 rs1296280144	79	E>V		No	ClinGen gnomAD
CA9802102 rs754557633	84	A>V		No	ClinGen ExAC gnomAD
CA408579225 rs1304898407	86	V>I		No	ClinGen gnomAD
CA408579201 rs1344322122	88	Q>K		No	ClinGen TOPMed
CA314081112 rs996600059	89	A>T		No	ClinGen Ensembl
rs1422601444 CA408579179	89	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA314081111 rs901023938	91	R>G		No	ClinGen TOPMed gnomAD
rs780011539 CA9802100	92	E>Q		No	ClinGen ExAC gnomAD
rs1285137410 CA408579123	95	D>G		No	ClinGen TOPMed
CA9802099 rs756056912	95	D>N		No	ClinGen ExAC gnomAD
rs1269977868 CA408579041	102	R>G		No	ClinGen gnomAD
CA314081110 rs868063030	102	R>Q		No	ClinGen TOPMed gnomAD
rs1269977868 CA408579039	102	R>W		No	ClinGen gnomAD
CA314081109 rs1011204866	104	A>T		No	ClinGen TOPMed
rs139457299 CA9802093	108	L>R		No	ClinGen 1000Genomes ExAC
TCGA novel	111	Q>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	115	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9802089 rs776985963	116	P>A		No	ClinGen ExAC TOPMed gnomAD
rs771436075 CA9802088	116	P>L		No	ClinGen ExAC gnomAD
CA408578823 rs776985963	116	P>S		No	ClinGen ExAC TOPMed gnomAD
rs774178481 CA9802086	117	G>E		No	ClinGen ExAC gnomAD
rs768464418 CA9802085	118	T>A		No	ClinGen ExAC gnomAD
rs1454886481 CA408578749	120	Y>F		No	ClinGen gnomAD
CA9802084 rs748811612	120	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA314081107 rs1036461217	122	S>T		No	ClinGen TOPMed
rs1600327188 CA408578679	124	E>G		No	ClinGen Ensembl
rs1343127692 CA408578686	124	E>Q		No	ClinGen gnomAD
CA408578622 rs1402012459	128	N>D		No	ClinGen TOPMed
CA408578578 rs1364350485	131	F>L		No	ClinGen TOPMed
rs756076815 CA9802082	132	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA408578538 rs1430465320	134	G>E		No	ClinGen gnomAD
CA9802081 rs745800708	136	N>K		No	ClinGen ExAC gnomAD
CA9802080 rs780912099	138	G>A		No	ClinGen ExAC gnomAD
CA9802079 rs757071036	139	R>H		No	ClinGen ExAC gnomAD
rs766818591 CA9802071	152	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1293138947 CA408578161	154	S>T		No	ClinGen TOPMed
rs773733186 CA9802069	155	V>A		No	ClinGen ExAC gnomAD
rs748329440 CA314081103	155	V>I		No	ClinGen TOPMed gnomAD
rs1234916006 CA408578103	156	D>V		No	ClinGen TOPMed
TCGA novel	161	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408578002 rs1600326715	161	V>G		No	ClinGen Ensembl
CA314081102 rs1040490728	161	V>L		No	ClinGen TOPMed
CA314081101 rs940931151	162	L>S		No	ClinGen TOPMed
CA408577938 rs1442234448	164	S>N		No	ClinGen TOPMed
rs1468552717 CA408577914	165	R>Q		No	ClinGen gnomAD
CA9802066 rs372986095	167	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA314081100 rs199692294	167	A>V		No	ClinGen 1000Genomes
CA408577762 rs1409233990	171	A>P		No	ClinGen TOPMed
rs745790964 CA9802064	176	D>E		No	ClinGen ExAC gnomAD
CA9802061 rs746751843	180	P>L		No	ClinGen ExAC gnomAD
CA9802058 rs752920927	186	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9802056 rs755052731	187	G>S		No	ClinGen ExAC gnomAD
CA408582900 rs1336276367	190	T>A		No	ClinGen TOPMed
CA9802038 rs749320983	194	L>F		No	ClinGen ExAC gnomAD
TCGA novel	201	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751979681 CA9802032	202	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA408582755 rs1385688261	203	S>C		No	ClinGen gnomAD
rs930721821 CA314075224	203	S>N		No	ClinGen Ensembl
CA408582748 rs1568844220	204	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1160520461 CA408582745	205	K>Q		No	ClinGen gnomAD
rs764743032 CA9802031	205	K>T		No	ClinGen ExAC gnomAD
CA408582709 rs1568844186	207	Q>R		No	ClinGen Ensembl
rs759194807 CA9802030	209	R>C	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA314075223 rs768665664	209	R>H		No	ClinGen gnomAD
rs768665664 CA408582668	209	R>L		No	ClinGen gnomAD
CA9802029 rs577055474	212	R>C		No	ClinGen ExAC gnomAD
rs763223337 CA9802028	212	R>H		No	ClinGen ExAC gnomAD
CA9802027 rs558849192	214	F>L		No	ClinGen 1000Genomes ExAC gnomAD
COSM184863 CA408582549 rs1447088802	216	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA408582544 rs1198306848	217	G>S		No	ClinGen TOPMed
rs1203035801 CA408582531	218	M>L		No	ClinGen gnomAD
CA9802025 rs772077664	219	T>A		No	ClinGen ExAC gnomAD
CA408582461 rs768692210	222	G>C		No	ClinGen ExAC TOPMed gnomAD
rs768692210 CA9802022	222	G>S		No	ClinGen ExAC TOPMed gnomAD
rs7362890 CA314075221	223	V>G		No	ClinGen Ensembl
CA9802020 rs780264826	223	V>L		No	ClinGen ExAC gnomAD
rs780264826 CA408582448	223	V>M		No	ClinGen ExAC gnomAD
CA314075220 rs11550472	226	L>P		No	ClinGen Ensembl
CA9802019 rs756307657	228	S>L		No	ClinGen ExAC gnomAD
rs1388146136 CA408582331	232	R>Q		No	ClinGen TOPMed gnomAD
CA9802018 rs746342082	232	R>W		No	ClinGen ExAC gnomAD

No associated diseases with Q07817

6 regional properties for Q07817

Type	Name	Position	InterPro Accession
domain	Apoptosis regulator, Bcl-2 protein, BH4	1 - 27	IPR003093
conserved_site	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	130 - 148	IPR020717
conserved_site	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	181 - 192	IPR020726
conserved_site	Apoptosis regulator, Bcl-2, BH3 motif, conserved site	86 - 100	IPR020728
conserved_site	Apoptosis regulator, Bcl-2, BH4 motif, conserved site	4 - 24	IPR020731
domain	Bcl-2, Bcl-2 homology region 1-3	90 - 188	IPR046371

Functions

		Description
EC Number
Subcellular Localization	[Isoform Bcl-X(L)]: Mitochondrion inner membrane Mitochondrion outer membrane Mitochondrion matrix Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Cytoplasm, cytosol Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus membrane ; Single-pass membrane protein ; Cytoplasmic side	After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity) Localizes to the centrosome when phosphorylated at Ser-49
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

14 GO annotations of cellular component

Name	Definition
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
Bcl-2 family protein complex	A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrial outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
PUMA-BCL-xl complex	A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.
synaptic vesicle membrane	The lipid bilayer surrounding a synaptic vesicle.

5 GO annotations of molecular function

Name	Definition
BH3 domain binding	Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.
identical protein binding	Binding to an identical protein or proteins.
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

47 GO annotations of biological process

Name	Definition
apoptotic mitochondrial changes	The morphological and physiological alterations undergone by mitochondria during apoptosis.
apoptotic process in bone marrow cell	The apoptotic process in cells in the bone marrow.
cellular response to alkaloid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.
cellular response to amino acid stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
cellular response to gamma radiation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
dendritic cell apoptotic process	Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
dendritic cell proliferation	The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
ectopic germ cell programmed cell death	Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
epithelial cell proliferation	The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
extrinsic apoptotic signaling pathway in absence of ligand	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.
fertilization	The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
germ cell development	The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
hepatocyte apoptotic process	Any apoptotic process in a hepatocyte, the main structural component of the liver.
in utero embryonic development	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
intrinsic apoptotic signaling pathway in response to DNA damage	The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
male gonad development	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
mitochondrion morphogenesis	The process in which the anatomical structures of a mitochondrion are generated and organized.
negative regulation of anoikis	Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of autophagy	Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
negative regulation of dendritic cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
negative regulation of developmental process	Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
negative regulation of execution phase of apoptosis	Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
negative regulation of intrinsic apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage.
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
negative regulation of neuron apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
negative regulation of protein localization to plasma membrane	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.
negative regulation of release of cytochrome c from mitochondria	Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
negative regulation of reproductive process	Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.
neuron apoptotic process	Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
ovarian follicle development	The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
positive regulation of mononuclear cell proliferation	Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
regulation of growth	Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
regulation of mitochondrial membrane permeability	Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.
regulation of mitochondrial membrane potential	Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
release of cytochrome c from mitochondria	The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
response to cycloheximide	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes.
response to cytokine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
suppression by virus of host apoptotic process	Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q16548	BCL2A1	Bcl-2-related protein A1	Homo sapiens (Human)	PR
Q64373	Bcl2l1	Bcl-2-like protein 1	Mus musculus (Mouse)	PR
O77737	BCL2L1	Bcl-2-like protein 1	Sus scrofa (Pig)	PR
P53563	Bcl2l1	Bcl-2-like protein 1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSQSNRELVV	DFLSYKLSQK	GYSWSQFSDV	EENRTEAPEG	TESEMETPSA	INGNPSWHLA
70	80	90	100	110	120
DSPAVNGATG	HSSSLDAREV	IPMAAVKQAL	REAGDEFELR	YRRAFSDLTS	QLHITPGTAY
130	140	150	160	170	180
QSFEQVVNEL	FRDGVNWGRI	VAFFSFGGAL	CVESVDKEMQ	VLVSRIAAWM	ATYLNDHLEP
190	200	210	220	230
WIQENGGWDT	FVELYGNNAA	AESRKGQERF	NRWFLTGMTV	AGVVLLGSLF	SRK