Q06466

PR
Gene name
TDA6 (YPR157W)
Protein name
Putative vacuolar protein sorting-associated protein TDA6
Names
Topoisomerase I damage affected protein 6
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPR157W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

26-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q06466

Entry ID Method Resolution Chain Position Source
AF-Q06466-F1 Predicted AlphaFoldDB

14 variants for Q06466

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-841285 8 I>M No SGRP
s16-841310 17 L>V No SGRP
s16-841445 62 S>P No SGRP
s16-841620 120 S>F No SGRP
s16-841680 140 G>D No SGRP
s16-841698 146 H>R No SGRP
s16-841775 172 P>S No SGRP
s16-841820 187 I>V No SGRP
s16-842040 260 K>M No SGRP
s16-842069 270 S>G No SGRP
s16-842082 274 G>E No SGRP
s16-842229 323 S>Y No SGRP
s16-842325 355 G>D No SGRP
s16-842456 399 V>M No SGRP

No associated diseases with Q06466

No regional properties for Q06466

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q06466

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53285 VPS62 Vacuolar protein sorting-associated protein 62 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MHCVLARILL WFLIVDLSVI RALVLPPLKD YDPLEPLMKR DMAMGQRNRF KVDGQLPPIL
70 80 90 100 110 120
NSTDVTDDQR SLHTPGEIPS YVINHCPLVH LYSEEKYWPS DIAEYVQNFQ IKDKNGNSIS
130 140 150 160 170 180
THENLTLHDL KAEYHVDLFG NKTETHIPSS EVFLTSLDDF DKDPKWLLGH LPEYGTGYNS
190 200 210 220 230 240
KAPAILIVVD KGNGWVDAFW FFFYPFNHGP FIMGHGPWGN HVGDWEHSLV RFYKGIPKYL
250 260 270 280 290 300
WMSAHSSGTG YRYEAVEKFK KLRKRKQQDS DDGGDTILER PLIFSARGTH ANYASAGQHA
310 320 330 340 350 360
HDIPFFFMPL SDFTDRGPLW DPSLNFYSYT FDGKTVTPSS EREESLGLDW LHFQGGWGDQ
370 380 390 400 410 420
QLPARDPRQK WCVAQWKYIG GPRGPLFKKL DRLNLCGGVK KWNFWNGGCP ARRLIKKAEG
430 440 450 460
LDSESTDLMG DNCGVLLYRI RPKWLRGILR FLMWRGILCS LMEFFTN