Q03327

PR
Gene name
UGO1
Protein name
Mitochondrial fusion and transport protein UGO1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR470C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

127-220 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q03327

Entry ID Method Resolution Chain Position Source
AF-Q03327-F1 Predicted AlphaFoldDB

8 variants for Q03327

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1400966 81 D>H No SGRP
s04-1400963 82 G>R No SGRP
s04-1400944 88 S>N No SGRP
s04-1400723 162 I>V No SGRP
s04-1400696 171 A>T No SGRP
s04-1400547 220 L>F No SGRP
s04-1400425 261 S>N No SGRP
s04-1400224 328 N>S No SGRP

No associated diseases with Q03327

No regional properties for Q03327

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q03327

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of mitochondrial outer membrane The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
thiamine transmembrane transporter activity Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.

4 GO annotations of biological process

Name Definition
mitochondrial fusion Merging of two or more mitochondria within a cell to form a single compartment.
mitochondrial inner membrane fusion The membrane organization process that joins two mitochondrial inner membranes to form a single membrane.
mitochondrial outer membrane fusion The membrane organization process that joins two mitochondrial outer membranes to form a single membrane.
thiamine pyrophosphate transmembrane transport The process in which thiamine pyrophosphate is transported across a membrane.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53257 TPC1 Mitochondrial thiamine pyrophosphate carrier 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MNNNNVTEAT SRAQIRPYYD PDSFNAGYSA VFKPDEGVVD PHGYTIASKL NVINSSPTTK
70 80 90 100 110 120
RMANALFKSS PMKKLSNSVN DGLSLEGSNG EITGLNNFEW AELVNIQKWR KIFEQLLDMF
130 140 150 160 170 180
FRKYFQLLIQ QPFDVARLLI QVGEFKIFKT TVDTNKPQAP IILRDEEGDG AAREGEEDAY
190 200 210 220 230 240
DEEEIDFFPI ERKIAEANST APIMAEETDH SHHEPTDISL TIAPQSLHTI DVINALFDQE
250 260 270 280 290 300
GIRGLWKANN TTFIYNFLSL SIDTWFTGLL SSFLGVPDPY FMEVINSPDI SKSFILALGA
310 320 330 340 350 360
GVFTSIILLP VDLIRTRLIV TSFKKKKNVK TDGKNMVTNT RSLRQLIRCW SWRKNGVSIP
370 380 390 400 410 420
LDMWSLTILQ SINNSFFNKL FDLVIYNQFH IEKYSQTVMY NTMKFFSKSL ELFIKLPLEN
430 440 450 460 470 480
LLRRCQLNYL LNDQRLSFKV DSTELIVKPK KYNGIWDVIR NNSNTNRGQL WNGWKVGVIS
490 500
LICGYGLQMM NKVDINMEQE KF