P53257

PR
Gene name
TPC1 (YGR096W)
Protein name
Mitochondrial thiamine pyrophosphate carrier 1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR096W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-45 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53257

Entry ID Method Resolution Chain Position Source
AF-P53257-F1 Predicted AlphaFoldDB

4 variants for P53257

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-676844 74 S>A No SGRP
s07-676904 94 F>L No SGRP
s07-676959 112 R>L No SGRP
s07-677221 199 N>K No SGRP

No associated diseases with P53257

3 regional properties for P53257

Type Name Position InterPro Accession
repeat Mitochondrial substrate/solute carrier 14 - 104 IPR018108-1
repeat Mitochondrial substrate/solute carrier 110 - 195 IPR018108-2
repeat Mitochondrial substrate/solute carrier 210 - 312 IPR018108-3

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
thiamine pyrophosphate transmembrane transporter activity Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other.
thiamine transmembrane transporter activity Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver.

2 GO annotations of biological process

Name Definition
mitochondrial thiamine pyrophosphate transmembrane transport The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion.
thiamine pyrophosphate transmembrane transport The process in which thiamine pyrophosphate is transported across a membrane.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03327 UGO1 Mitochondrial fusion and transport protein UGO1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MFKEEDSLRK GQNVAAWKTL LAGAVSGLLA RSITAPMDTI KIRLQLTPAN GLKPFGSQVM
70 80 90 100 110 120
EVARSMIKNE GIRSFWKGNI PGSLLYVTYG SAQFSSYSLF NRYLTPFGLE ARLHSLVVGA
130 140 150 160 170 180
FAGITSSIVS YPFDVLRTRL VANNQMHSMS ITREVRDIWK LEGLPGFFKG SIASMTTITL
190 200 210 220 230 240
TASIMFGTYE TIRIYCDENE KTTAAHKKWE LATLNHSAGT IGGVIAKIIT FPLETIRRRM
250 260 270 280 290 300
QFMNSKHLEK FSRHSSVYGS YKGYGFARIG LQILKQEGVS SLYRGILVAL SKTIPTTFVS
310
FWGYETAIHY LRMY