Q02336
PR
Gene name |
ADA2 (YDR448W, D9461.33) |
Protein name |
Transcriptional adapter 2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR448W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q02336
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2ELJ | NMR | - | A | 354-434 | PDB |
| 6CW2 | X-ray | 267 A | C | 1-120 | PDB |
| 6CW3 | X-ray | 198 A | E/G | 2-120 | PDB |
| AF-Q02336-F1 | Predicted | AlphaFoldDB |
4 variants for Q02336
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1356343 | 96 | G>D | No | SGRP | |
| s04-1356889 | 278 | A>E | No | SGRP | |
| s04-1357093 | 346 | S>N | No | SGRP | |
| s04-1357258 | 401 | T>I | No | SGRP |
No associated diseases with Q02336
6 regional properties for Q02336
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase M41 | 563 - 744 | IPR000642 |
| domain | AAA+ ATPase domain | 341 - 480 | IPR003593 |
| domain | ATPase, AAA-type, core | 346 - 477 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 448 - 466 | IPR003960 |
| domain | Peptidase M41, FtsH extracellular | 157 - 241 | IPR011546 |
| domain | AAA ATPase, AAA+ lid domain | 509 - 547 | IPR041569 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| ADA complex | A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex. |
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| SAGA complex | A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). |
| SAGA-type complex | A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs). |
| SLIK (SAGA-like) complex | A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| phosphatidylserine binding | Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
| transcription coactivator activity | A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. |
| zinc ion binding | Binding to a zinc ion (Zn). |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone acetylation | The modification of a histone by the addition of an acetyl group. |
| histone deubiquitination | The modification of histones by removal of ubiquitin groups. |
| positive regulation of histone acetylation | Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
| rDNA heterochromatin assembly | The formation of heterochromatin at ribosomal DNA, characterized by the modified histone H3K9me3. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| replication-born double-strand break repair via sister chromatid exchange | The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks. |
| subtelomeric heterochromatin assembly | The compaction of chromatin into heterochromatin at the subtelomeric region. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNKFHCDVC | SADCTNRVRV | SCAICPEYDL | CVPCFSQGSY | TGKHRPYHDY | RIIETNSYPI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LCPDWGADEE | LQLIKGAQTL | GLGNWQDIAD | HIGSRGKEEV | KEHYLKYYLE | SKYYPIPDIT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QNIHVPQDEF | LEQRRHRIES | FRERPLEPPR | KPMASVPSCH | EVQGFMPGRL | EFETEFENEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGPVKDMVFE | PDDQPLDIEL | KFAILDIYNS | RLTTRAEKKR | LLFENHLMDY | RKLQAIDKKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKEAKELYNR | IKPFARVMTA | QDFEEFSKDI | LEELHCRARI | QQLQEWRSNG | LTTLEAGLKY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ERDKQARISS | FEKFGASTAA | SLSEGNSRYR | SNSAHRSNAE | YSQNYSENGG | RKKNMTISDI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QHAPDYALLS | NDEQQLCIQL | KILPKPYLVL | KEVMFRELLK | TGGNLSKSAC | RELLNIDPIK |
| 430 | |||||
| ANRIYDFFQS | QNWM |