AiPD: Autoinhibited Protein Database

Q00403

Gene name	GTF2B (TF2B, TFIIB)
Protein name	Transcription initiation factor IIB
Names	General transcription factor TFIIB, S300-II
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2959
EC number	2.3.1.48: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-106 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

37-106 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

53 structures for Q00403

Entry ID	Method	Resolution	Chain	Position	Source
1C9B	X-ray	265 A	A/E/I/M/Q	110-316	PDB
1DL6	NMR	-	A	2-59	PDB
1RLY	NMR	-	A	1-60	PDB
1RO4	NMR	-	A	1-60	PDB
1TFB	NMR	-	A	112-316	PDB
1VOL	X-ray	270 A	A	113-316	PDB
2PHG	NMR	-	A	112-316	PDB
5IY6	EM	720 A	M	1-316	PDB
5IY7	EM	860 A	M	1-316	PDB
5IY8	EM	790 A	M	1-316	PDB
5IY9	EM	630 A	M	1-316	PDB
5IYA	EM	540 A	M	1-316	PDB
5IYB	EM	390 A	M	1-316	PDB
5IYC	EM	390 A	M	1-316	PDB
5IYD	EM	390 A	M	1-316	PDB
5WH1	X-ray	339 A	A/B/C/D	107-316	PDB
6O9L	EM	720 A	M	1-316	PDB
7EDX	EM	450 A	R	1-316	PDB
7EG7	EM	620 A	R	1-316	PDB
7EG8	EM	740 A	R	1-316	PDB
7EG9	EM	370 A	R	1-316	PDB
7EGA	EM	410 A	R	1-316	PDB
7EGB	EM	330 A	R	1-316	PDB
7EGC	EM	390 A	R	1-316	PDB
7ENA	EM	407 A	BA	1-316	PDB
7ENC	EM	413 A	BA	1-316	PDB
7LBM	EM	480 A	O	1-316	PDB
7NVR	EM	450 A	M	1-316	PDB
7NVS	EM	280 A	M	1-316	PDB
7NVT	EM	290 A	M	1-316	PDB
7NVU	EM	250 A	M	1-316	PDB
7NVY	EM	730 A	M	1-316	PDB
7NVZ	EM	720 A	M	1-316	PDB
7NW0	EM	660 A	M	1-316	PDB
7ZWC	EM	320 A	M	1-316	PDB
7ZWD	EM	300 A	M	1-316	PDB
7ZX7	EM	340 A	M	1-316	PDB
7ZX8	EM	300 A	M	1-316	PDB
7ZXE	EM	350 A	M	1-316	PDB
8BVW	EM	400 A	M	1-316	PDB
8BYQ	EM	410 A	M	1-316	PDB
8BZ1	EM	380 A	M	1-316	PDB
8GXQ	EM	504 A	BA	1-316	PDB
8GXS	EM	416 A	BA	1-316	PDB
8WAK	EM	547 A	R	1-316	PDB
8WAL	EM	852 A	R	1-316	PDB
8WAN	EM	607 A	R	1-316	PDB
8WAO	EM	640 A	R	1-316	PDB
8WAP	EM	585 A	R	1-316	PDB
8WAQ	EM	629 A	R	1-316	PDB
8WAR	EM	720 A	R	1-316	PDB
8WAS	EM	613 A	R	1-316	PDB
AF-Q00403-F1	Predicted				AlphaFoldDB

160 variants for Q00403

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1362259620 CA340991945	3	S>F		No	ClinGen gnomAD
CA26531917 rs907201514	4	T>A		No	ClinGen Ensembl
CA26531918 rs907201514	4	T>P		No	ClinGen Ensembl
rs554448069 CA26531897	6	R>H		No	ClinGen 1000Genomes gnomAD
rs1201194995 CA340990529	7	L>S		No	ClinGen TOPMed
CA340990448 rs1570739172	10	L>P		No	ClinGen Ensembl
CA340990451 rs1570739173	10	L>V		No	ClinGen Ensembl
rs11546873 CA340990378	14	T>A		No	ClinGen gnomAD
TCGA novel	14	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs952306137 CA26528856	14	T>K		No	ClinGen Ensembl
rs11546873 CA26528861	14	T>S		No	ClinGen gnomAD
CA26528851 rs1029671726	15	C>R		No	ClinGen Ensembl
rs1156309703 CA340990316	16	P>Q		No	ClinGen TOPMed
VAR_011977 rs1804499 CA26528850	19	P>S		No	ClinGen UniProt Ensembl dbSNP
CA340990188 rs1329187634	20	D>N		No	ClinGen gnomAD
rs138269428 CA938227	21	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1371758655 CA340990082	22	I>F		No	ClinGen gnomAD
CA340990025 rs1365392195	24	V>A		No	ClinGen TOPMed
CA340989958 rs1169047818	27	Y>H		No	ClinGen gnomAD
CA938222 rs202186098	30	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771847209 CA938220	32	M>T		No	ClinGen ExAC TOPMed gnomAD
rs564862923 CA938221	32	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1236964358 CA340989688	33	I>S		No	ClinGen gnomAD
rs1176236860 CA340989683	34	C>R		No	ClinGen gnomAD
TCGA novel	36	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1439109360 CA340989659	37	C>Y		No	ClinGen gnomAD
CA340989650 rs1251131658	38	G>D		No	ClinGen gnomAD
CA340989636 rs1277912560	40	V>A		No	ClinGen TOPMed
CA938219 rs747704910	42	G>S		No	ClinGen ExAC
rs773113598 CA938203	43	D>N		No	ClinGen ExAC gnomAD
rs761582998 CA938202	44	R>P		No	ClinGen ExAC TOPMed gnomAD
rs761582998 CA938201 COSM912912	44	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA341010180 rs1352867601	44	R>W		No	ClinGen gnomAD
TCGA novel	45	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768052513 CA938199	47	D>E		No	ClinGen ExAC gnomAD
rs1339225620 CA341010158	48	V>M		No	ClinGen gnomAD
rs1360336600 CA341010082	58	D>E		No	ClinGen TOPMed gnomAD
rs201345481 CA26556679	61	T>A		No	ClinGen Ensembl
rs1402111568 CA341010063	61	T>R		No	ClinGen gnomAD
CA341010058 rs1408006417	62	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	63	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	63	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	64	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341010032 rs1162137076	66	R>*		No	ClinGen gnomAD
rs1321906416 CA341010012	69	D>G		No	ClinGen gnomAD
CA341010001 rs1402796500	71	Q>*		No	ClinGen gnomAD
CA341009997 rs1188620872	71	Q>H		No	ClinGen gnomAD
CA938196 rs770326014	71	Q>P		No	ClinGen ExAC gnomAD
rs367866313 CA938195	72	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs375702396 CA938194	74	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA341009971 rs1448959703	76	S>G		No	ClinGen gnomAD
rs1372257824 CA341009962	77	D>H		No	ClinGen TOPMed
TCGA novel	78	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1332832495 CA341009946	79	D>G		No	ClinGen gnomAD
CA341009947 rs1209305731	79	D>Y		No	ClinGen gnomAD
rs777916117 CA938191	81	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1295618595 CA341009933	81	S>P		No	ClinGen gnomAD
CA938188 rs766268144	83	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	89	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	92	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341009439 rs1457142977	92	S>N		No	ClinGen TOPMed
TCGA novel	93	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1366936744 CA341009412	95	E>D		No	ClinGen TOPMed
rs779074866 CA938167	95	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA341009405 rs1424721672	96	F>L		No	ClinGen TOPMed
rs906155833 CA26553113	98	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs374036755 CA938166	98	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1457417798 CA341009365	102	Q>R		No	ClinGen gnomAD
rs1570719596 CA341009353	104	R>G		No	ClinGen Ensembl
CA938163 rs577562784	104	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	105	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA938161 rs763691872	107	M>K		No	ClinGen ExAC gnomAD
CA938162 rs751393361	107	M>V		No	ClinGen ExAC gnomAD
rs762642710 CA938160	108	S>R		No	ClinGen ExAC TOPMed gnomAD
rs917631279 CA26553052	110	S>C		No	ClinGen gnomAD
CA341009298 rs1303763642	112	R>Q		No	ClinGen gnomAD
rs774955018 CA938159	115	M>I		No	ClinGen ExAC
CA341009269 rs1445376856	116	N>S		No	ClinGen gnomAD
rs779471099 CA26553000	119	K>N		No	ClinGen Ensembl
CA26553027 rs757282415	119	K>Q		No	ClinGen Ensembl
CA341009248 rs1299775229	119	K>R		No	ClinGen gnomAD
CA938156 rs777180677	121	I>N		No	ClinGen ExAC gnomAD
CA341009234 rs777180677	121	I>T		No	ClinGen ExAC gnomAD
CA938154 rs747415886	124	M>T		No	ClinGen ExAC gnomAD
CA938155 rs771424437	124	M>V		No	ClinGen ExAC gnomAD
CA341009194 rs1436429762	127	R>K		No	ClinGen gnomAD
CA341009181 rs1174537939	129	N>S		No	ClinGen gnomAD
rs773605428 CA938152	131	P>A		No	ClinGen ExAC gnomAD
rs144944840 VAR_035722 COSM32382 CA938151	132	R>Q	Variant assessed as Somatic; 4.623e-05 impact. large_intestine a colorectal cancer sample; somatic mutation [NCI-TCGA, Cosmic, UniProt]	No	ClinGen cosmic curated UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA938131 COSM78959 rs772494214	137	R>*	ovary Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1484694065 CA341009068	144	Q>R		No	ClinGen gnomAD
CA341009029 rs1262197752	149	K>R		No	ClinGen gnomAD
CA341008982 rs1215871671	156	N>S		No	ClinGen gnomAD
rs1320646621 CA341008963	159	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1291314154 CA341008957	160	A>T		No	ClinGen gnomAD
rs200968533 CA938129	165	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
CA26550447 rs530707339	181	C>S		No	ClinGen 1000Genomes
TCGA novel	182	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA938100 COSM197961 rs769046476	183	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA938099 COSM1320858 rs763288295	185	R>*	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs370883543 CA938098	185	R>Q	Variant assessed as Somatic; 4.629e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA938095 rs769996459	193	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA938094 rs745878059	194	C>R		No	ClinGen ExAC gnomAD
CA341008200 rs1468573419	198	I>T		No	ClinGen gnomAD
rs1570717601 CA341008175	201	A>T		No	ClinGen Ensembl
rs1249692707 CA341008169	201	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA341008136 rs1366171378	205	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs778703932 CA938090	207	D>H		No	ClinGen ExAC gnomAD
CA341008091 rs1297190720	210	T>S		No	ClinGen gnomAD
CA341008073 rs1433340792	211	T>I		No	ClinGen gnomAD
CA341008078 rs1347425291	211	T>S		No	ClinGen gnomAD
TCGA novel	215	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1390177938 CA341007972	223	C>F		No	ClinGen gnomAD
CA938085 CA341007911 rs749892281	230	M>I		No	ClinGen ExAC gnomAD
rs755712098 CA938086	230	M>T		No	ClinGen ExAC gnomAD
rs1454300512 CA341007879	234	H>R		No	ClinGen TOPMed gnomAD
CA938083 rs757680981	234	H>Y		No	ClinGen ExAC gnomAD
TCGA novel	236	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA938082 rs141868697	237	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764583147 CA938081	237	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1439496315 CA341007844	240	V>M		No	ClinGen gnomAD
rs138805281 CA938080	241	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA26550299 rs2794318	242	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA341007831 rs2794318	242	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	244	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200095317 CA938078	245	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1172717480 CA341007774	251	I>V		No	ClinGen TOPMed
CA341007746 rs1557652559	255	A>V		No	ClinGen Ensembl
CA341007716 rs1447378287	260	M>V		No	ClinGen gnomAD
rs1338031442 CA341007705	261	A>D		No	ClinGen gnomAD
TCGA novel	261	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs949155568 CA26550235	261	A>T		No	ClinGen TOPMed
CA938075 rs770996219	263	Q>E		No	ClinGen ExAC gnomAD
rs1314277478 CA341007653	269	R>K		No	ClinGen gnomAD
rs1383531433 CA341007645	270	T>N		No	ClinGen gnomAD
TCGA novel	271	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341007642 rs1470912156	271	Q>K		No	ClinGen gnomAD
CA341007348 rs1188370828	276	D>N		No	ClinGen gnomAD
rs1241013522 CA341007331	277	I>T		No	ClinGen TOPMed
CA341007336 rs1474987136	277	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	279	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369635514 CA26546514	287	Q>L		No	ClinGen ESP gnomAD
rs753106373 CA938061	292	I>V		No	ClinGen ExAC gnomAD
rs370884098 CA938059	293	Y>C		No	ClinGen ExAC gnomAD
rs370884098 CA26546440	293	Y>F		No	ClinGen ExAC gnomAD
CA938060 rs765545366	293	Y>H		No	ClinGen ExAC gnomAD
CA938057 rs766376225 COSM1688002	294	P>S	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA341006971 rs1268006914	295	R>*		No	ClinGen gnomAD
CA938056 rs760691499	295	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA341006892 rs1438148692	298	D>E		No	ClinGen gnomAD
CA26546389 rs911750793	299	L>V		No	ClinGen Ensembl
rs749117858 CA938053	302	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1343043074 CA341006805	302	T>I		No	ClinGen gnomAD
TCGA novel	302	T>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775240117 CA938052	303	D>G		No	ClinGen ExAC gnomAD
TCGA novel	308	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745536592 COSM3741420 CA938050	308	T>I	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
TCGA novel	309	P>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780829770 CA938049	309	P>S		No	ClinGen ExAC gnomAD
CA341006626 rs1226478883	310	V>A		No	ClinGen gnomAD

No associated diseases with Q00403

7 regional properties for Q00403

Type	Name	Position	InterPro Accession
domain	Zinc finger, TFIIB-type	11 - 55	IPR013137
domain	Transcription factor TFIIB, cyclin-like domain	112 - 200	IPR013150-1
domain	Transcription factor TFIIB, cyclin-like domain	206 - 293	IPR013150-2
domain	Cyclin-like domain	119 - 200	IPR013763-1
domain	Cyclin-like domain	213 - 294	IPR013763-2
conserved_site	Transcription factor TFIIB, conserved site	153 - 168	IPR023486-1
conserved_site	Transcription factor TFIIB, conserved site	247 - 262	IPR023486-2

Functions

		Description
EC Number	2.3.1.48	Transferring groups other than amino-acyl groups
Subcellular Localization	Nucleus Chromosome	Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis (PubMed:24441171) Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle (PubMed:24441171)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nuclear body	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-DNA complex	A macromolecular complex containing both protein and DNA molecules.
RNA polymerase II transcription regulator complex	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
transcription factor TFIID complex	A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters.
transcription preinitiation complex	A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.

10 GO annotations of molecular function

Name	Definition
acetyltransferase activity	Catalysis of the transfer of an acetyl group to an acceptor molecule.
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
histone acetyltransferase activity	Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.
nuclear thyroid hormone receptor binding	Binding to a nuclear thyroid hormone receptor.
promoter-specific chromatin binding	Binding to a section of chromatin that is associated with gene promoter sequences of DNA.
RNA polymerase II complex binding	Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
RNA polymerase II core promoter sequence-specific DNA binding	Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
RNA polymerase II general transcription initiation factor activity	A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription.
TBP-class protein binding	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs).
zinc ion binding	Binding to a zinc ion (Zn).

9 GO annotations of biological process

Name	Definition
DNA-templated transcription initiation	The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
positive regulation of core promoter binding	Any process that activates or increases the frequency, rate or extent of core promoter binding.
protein acetylation	The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic
RNA polymerase II core complex assembly	The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex.
RNA polymerase II preinitiation complex assembly	The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.
transcription by RNA polymerase II	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription initiation at RNA polymerase II promoter	A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.
transcriptional start site selection at RNA polymerase II promoter	Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
viral transcription	The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q92994	BRF1	Transcription factor IIIB 90 kDa subunit	Homo sapiens (Human)	PR

10	20	30	40	50	60
MASTSRLDAL	PRVTCPNHPD	AILVEDYRAG	DMICPECGLV	VGDRVIDVGS	EWRTFSNDKA
70	80	90	100	110	120
TKDPSRVGDS	QNPLLSDGDL	STMIGKGTGA	ASFDEFGNSK	YQNRRTMSSS	DRAMMNAFKE
130	140	150	160	170	180
ITTMADRINL	PRNIVDRTNN	LFKQVYEQKS	LKGRANDAIA	SACLYIACRQ	EGVPRTFKEI
190	200	210	220	230	240
CAVSRISKKE	IGRCFKLILK	ALETSVDLIT	TGDFMSRFCS	NLCLPKQVQM	AATHIARKAV
250	260	270	280	290	300
ELDLVPGRSP	ISVAAAAIYM	ASQASAEKRT	QKEIGDIAGV	ADVTIRQSYR	LIYPRAPDLF
310
PTDFKFDTPV	DKLPQL