AiPD: Autoinhibited Protein Database

Gene name	G3bp2
Protein name	Ras GTPase-activating protein-binding protein 2
Names	G3BP-2, GAP SH3 domain-binding protein 2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:23881
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

107-269 (Predicted disordered autoinhibitory region) PR

107-269 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P97379-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3395512132	20	Y>N	No	EVA
rs3388751376	28	E>*	No	EVA
rs3388776609	48	S>N	No	EVA
rs3388767092	80	V>M	No	EVA
rs3388765891	85	T>S	No	EVA
rs3388770835	95	M>V	No	EVA
rs3388768135	97	L>S	No	EVA
rs3388751396	101	S>G	No	EVA
rs3388771121	110	Q>*	No	EVA
rs3388756093	111	T>N	No	EVA
rs3388765882	117	E>D	No	EVA
rs3388770910	150	E>K	No	EVA
rs3388768199	174	A>V	No	EVA
rs3388763707	183	N>K	No	EVA
rs3388773236	200	P>Q	No	EVA
rs3388770883	203	E>V	No	EVA
rs3388771072	231	A>T	No	EVA
rs3388763696	285	Q>H	No	EVA
rs3388770619	298	E>D	No	EVA
rs3388770558	310	G>A	No	EVA
rs13460020	318	D>A	No	EVA
rs3388771039	325	I>T	No	EVA
rs3388756150	327	Y>H	No	EVA
rs3388771113	332	Q>*	No	EVA
rs3388756104	381	D>N	No	EVA
rs3395638932	384	P>L	No	EVA
rs3388751401	423	D>N	No	EVA
rs3395837756	456	P>R	No	EVA
rs3395512185	457	R>G	No	EVA
rs3395838142	460	M>L	No	EVA

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	331 - 409	IPR000504
domain	Nuclear transport factor 2 domain	11 - 133	IPR002075
domain	Nuclear transport factor 2, eukaryote	7 - 135	IPR018222
domain	G3BP2, RNA recognition motif	326 - 408	IPR034376

		Description
EC Number
Subcellular Localization	Cytoplasm Cytoplasm, Stress granule
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.

Name	Definition
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

Name	Definition
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of stress granule assembly	Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
small GTPase mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.
stress granule assembly	The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9UN86	G3BP2	Ras GTPase-activating protein-binding protein 2	Homo sapiens (Human)	PR