P97351
PR
Gene name |
Rps3a (Rps3a1) |
Protein name |
40S ribosomal protein S3a |
Names |
Protein TU-11 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20091 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
5 variants for P97351
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388637220 | 54 | G>E | No | EVA | |
| rs3388640984 | 117 | W>L | No | EVA | |
| rs13463147 | 210 | V>A | No | EVA | |
| rs3388626969 | 210 | V>F | No | EVA | |
| rs13463146 | 215 | V>E | No | EVA |
No associated diseases with P97351
1 regional properties for P97351
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Ribosomal protein S3Ae, conserved site | 62 - 74 | IPR018281 |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| cytosolic ribosome | A ribosome located in the cytosol. |
| cytosolic small ribosomal subunit | The small subunit of a ribosome located in the cytosol. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| small ribosomal subunit | The smaller of the two subunits of a ribosome. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA 5'-UTR binding | Binding to an mRNA molecule at its 5' untranslated region. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
| translation initiation factor binding | Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cytoplasmic translation | The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. |
| negative regulation of apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P61247 | RPS3A | 40S ribosomal protein S3a | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVGKNKRLT | KGGKKGAKKK | VVDPFSKKDW | YDVKAPAMFN | IRNIGKTLVT | RTQGTKIASD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GLKGRVFEVS | LADLQNDEVA | FRKFKLITED | VQGKNCLTNF | HGMDLTRDKM | CSMVKKWQTM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IEAHVDVKTT | DGYLLRLFCV | GFTKKRNNQI | RKTSYAQHQQ | VRQIRKKMME | IMTREVQTND |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LKEVVNKLIP | DSIGKDIEKA | CQSIYPLHDV | FVRKVKMLKK | PKFELGKLME | LHGEGGSSGK |
| 250 | 260 | ||||
| AAGDETGAKV | ERADGYEPPV | QESV |