AiPD: Autoinhibited Protein Database

P61247

Gene name	RPS3A
Protein name	40S ribosomal protein S3a
Names	Small ribosomal subunit protein eS1, v-fos transformation effector protein, Fte-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6189
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

201-264 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

201-264 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

97 structures for P61247

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	SB	1-264	PDB
4V6X	EM	500 A	AB	1-264	PDB
5A2Q	EM	390 A	B	1-264	PDB
5AJ0	EM	350 A	BB	1-264	PDB
5FLX	EM	390 A	B	1-264	PDB
5LKS	EM	360 A	SB	1-264	PDB
5OA3	EM	430 A	B	1-264	PDB
5T2C	EM	360 A	Ap	1-264	PDB
5VYC	X-ray	600 A	B1/B2/B3/B4/B5/B6	1-264	PDB
6FEC	EM	630 A	i	19-233	PDB
6G18	EM	360 A	B	1-264	PDB
6G4S	EM	400 A	B	1-264	PDB
6G4W	EM	450 A	B	1-264	PDB
6G51	EM	410 A	B	1-264	PDB
6G53	EM	450 A	B	1-264	PDB
6G5H	EM	360 A	B	1-264	PDB
6G5I	EM	350 A	B	1-264	PDB
6IP5	EM	390 A	2o	1-264	PDB
6IP6	EM	450 A	2o	1-264	PDB
6IP8	EM	390 A	2o	1-264	PDB
6OLE	EM	310 A	SB	21-234	PDB
6OLF	EM	390 A	SB	21-234	PDB
6OLG	EM	340 A	BB	22-233	PDB
6OLI	EM	350 A	SB	21-234	PDB
6OLZ	EM	390 A	BB	22-233	PDB
6OM0	EM	310 A	SB	21-234	PDB
6OM7	EM	370 A	SB	21-234	PDB
6QZP	EM	290 A	SB	21-234	PDB
6XA1	EM	280 A	SB	22-232	PDB
6Y0G	EM	320 A	SB	1-264	PDB
6Y2L	EM	300 A	SB	1-264	PDB
6Y57	EM	350 A	SB	1-264	PDB
6YBD	EM	330 A	O	1-264	PDB
6YBW	EM	310 A	O	1-264	PDB
6Z6L	EM	300 A	SB	1-264	PDB
6Z6M	EM	310 A	SB	1-264	PDB
6Z6N	EM	290 A	SB	1-264	PDB
6ZLW	EM	260 A	C	1-264	PDB
6ZM7	EM	270 A	SB	1-264	PDB
6ZME	EM	300 A	SB	1-264	PDB
6ZMI	EM	260 A	SB	1-264	PDB
6ZMO	EM	310 A	SB	1-264	PDB
6ZMT	EM	300 A	C	1-264	PDB
6ZMW	EM	370 A	O	1-264	PDB
6ZN5	EM	320 A	C	21-233	PDB
6ZOJ	EM	280 A	B	1-264	PDB
6ZOK	EM	280 A	B	1-264	PDB
6ZON	EM	300 A	p	1-264	PDB
6ZP4	EM	290 A	p	1-264	PDB
6ZUO	EM	310 A	B	1-264	PDB
6ZV6	EM	290 A	B	1-264	PDB
6ZVH	EM	290 A	B	1-264	PDB
6ZVJ	EM	380 A	p	23-233	PDB
6ZXD	EM	320 A	B	1-264	PDB
6ZXE	EM	300 A	B	1-264	PDB
6ZXF	EM	370 A	B	1-264	PDB
6ZXG	EM	260 A	B	1-264	PDB
6ZXH	EM	270 A	B	1-264	PDB
7A09	EM	350 A	p	1-264	PDB
7K5I	EM	290 A	B	1-264	PDB
7MQ8	EM	360 A	NM	1-264	PDB
7MQ9	EM	387 A	NM	1-264	PDB
7MQA	EM	270 A	NM	1-264	PDB
7QP6	EM	470 A	O	1-264	PDB
7QP7	EM	370 A	O	1-264	PDB
7QVP	EM	300 A	RB/SB	1-264	PDB
7R4X	EM	215 A	B	1-264	PDB
7TQL	EM	340 A	B/C	21-233	PDB
7WTS	EM	320 A	B	1-264	PDB
7WTT	EM	310 A	B	1-264	PDB
7WTU	EM	300 A	B	1-264	PDB
7WTV	EM	350 A	B	1-264	PDB
7WTW	EM	320 A	B	1-264	PDB
7WTX	EM	310 A	B	1-264	PDB
7WTZ	EM	300 A	B	1-264	PDB
7WU0	EM	330 A	B	1-264	PDB
7XNX	EM	270 A	SB	1-264	PDB
7XNY	EM	250 A	SB	1-264	PDB
8G5Y	EM	229 A	SB	1-264	PDB
8G5Z	EM	264 A	SB	2-234	PDB
8G60	EM	254 A	SB	1-264	PDB
8G61	EM	294 A	SB	1-264	PDB
8G6J	EM	280 A	SB	1-264	PDB
8GLP	EM	167 A	SB	1-264	PDB
8IFD	EM	259 A	2o	1-264	PDB
8IFE	EM	257 A	2o	1-264	PDB
8JDJ	EM	250 A	y	1-264	PDB
8JDK	EM	226 A	y	1-264	PDB
8JDL	EM	242 A	y	1-264	PDB
8JDM	EM	267 A	y	1-264	PDB
8OZ0	EM	350 A	P	1-264	PDB
8PPK	EM	298 A	B	1-264	PDB
8PPL	EM	265 A	AB	1-264	PDB
8T4S	EM	260 A	B	1-264	PDB
8Y0W	EM	340 A	SB	1-264	PDB
8Y0X	EM	330 A	SB	1-264	PDB
AF-P61247-F1	Predicted				AlphaFoldDB

129 variants for P61247

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA3104034 rs765643289	5	K>Q		No	ClinGen ExAC
rs1317361557 CA358429888	6	N>I		No	ClinGen TOPMed
rs1232551477 CA358429900	8	R>G		No	ClinGen gnomAD
CA358429907 rs1346660792	9	L>F		No	ClinGen TOPMed gnomAD
CA358429906 rs1346660792	9	L>V		No	ClinGen TOPMed gnomAD
rs747512037 CA3104038	10	T>M		No	ClinGen ExAC gnomAD
rs889970160 CA107822351	12	G>S		No	ClinGen gnomAD
CA358429957 rs917153196	17	A>P		No	ClinGen TOPMed gnomAD
rs917153196 CA107822367	17	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	18	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3104071 rs772781421	22	V>I		No	ClinGen ExAC gnomAD
rs1414556731 CA358430453	31	Y>H		No	ClinGen gnomAD
CA3104072 rs762646465	32	D>G		No	ClinGen ExAC TOPMed gnomAD
rs948316663 CA107823059	32	D>N		No	ClinGen Ensembl
TCGA novel	32	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766712231 CA3104073	35	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1382725797 CA358430486	36	P>S		No	ClinGen gnomAD
CA107823093 rs939317077	37	A>P		No	ClinGen gnomAD
TCGA novel	37	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1561164066 CA358430497	38	M>V		No	ClinGen Ensembl
TCGA novel rs753204579 CA3104077	39	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
CA3104078 rs756177696	40	N>S		No	ClinGen ExAC gnomAD
CA358430546 rs1379172904	44	I>T		No	ClinGen gnomAD
CA107823115 rs11548500	53	Q>*		No	ClinGen Ensembl
TCGA novel	61	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	61	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs541190765 CA358430687	64	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs541190765 CA3104102	64	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA358430694 rs1233060413	65	R>C		No	ClinGen TOPMed
rs1369719747 CA358430739	71	L>R		No	ClinGen TOPMed
rs1190145783 CA358430797	79	V>A		No	ClinGen TOPMed gnomAD
rs1448281761 CA358430793	79	V>I		No	ClinGen TOPMed
TCGA novel	83	K>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1168116362 CA358430831	84	F>Y		No	ClinGen gnomAD
CA358430840 rs1401762602	85	K>R		No	ClinGen gnomAD
CA358430855 rs754809934	87	I>M		No	ClinGen ExAC gnomAD
CA3104106 rs780944897	88	T>S		No	ClinGen ExAC gnomAD
CA358430866 rs1438310950	89	E>V		No	ClinGen gnomAD
CA107823374 rs533195948	90	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
CA3104109 rs777505592	93	G>A		No	ClinGen ExAC gnomAD
rs1361512293 CA358430914	93	G>C		No	ClinGen gnomAD
rs748844257 CA3104110	95	N>T		No	ClinGen ExAC gnomAD
CA107823396 rs1025970589	99	N>D		No	ClinGen Ensembl
CA358431024 rs1180771443	101	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1487516361 CA358431053	103	M>V		No	ClinGen TOPMed gnomAD
CA358431086 rs1171418820	105	L>P		No	ClinGen gnomAD
rs772610299 CA3104114	107	R>C		No	ClinGen ExAC gnomAD
CA3104117 rs764663585	110	M>T		No	ClinGen ExAC gnomAD
rs1375097212 CA358431187	112	S>C		No	ClinGen gnomAD
TCGA novel	116	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	120	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372347928 CA3104164	120	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs188256601 CA3104165	121	I>T		No	ClinGen 1000Genomes ExAC gnomAD
CA3104168 rs373671463	125	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs758026158 CA3104170	128	K>R		No	ClinGen ExAC gnomAD
rs779413502 CA3104171	129	T>S		No	ClinGen ExAC gnomAD
CA3104173 rs754585630	131	D>N		No	ClinGen ExAC gnomAD
rs1368393964 CA358432328	132	G>S		No	ClinGen gnomAD
CA3104175 rs748526086	135	L>F		No	ClinGen ExAC TOPMed gnomAD
rs748526086 CA3104176	135	L>V		No	ClinGen ExAC TOPMed gnomAD
rs778282736 CA3104177 COSM1226987	136	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA3104178 rs202030866	136	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1348233171 CA358432453	139	C>F		No	ClinGen TOPMed
CA3104181 rs746164921	141	G>S		No	ClinGen ExAC gnomAD
CA107824738 rs761078443	146	R>C		No	ClinGen TOPMed
CA358432544 rs761078443	146	R>S		No	ClinGen TOPMed
rs1554025496 CA358432563	147	N>K		No	ClinGen Ensembl
CA3104183 rs775792276	151	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM328158 CA3104189 rs139979828	157	Q>P	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1396086909 CA358432707	160	Q>R		No	ClinGen gnomAD
rs754453994 CA3104190	162	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1419453482 CA358432731	162	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3104191 rs767099698	165	R>Q		No	ClinGen ExAC gnomAD
CA358432768 rs1171792547	165	R>W		No	ClinGen TOPMed
rs1803600 CA107824777	166	K>R		No	ClinGen Ensembl
rs1358218351 CA358432798	167	K>M		No	ClinGen gnomAD
rs1436635204 CA358432833	169	M>I		No	ClinGen TOPMed
rs528453010 CA3104192	169	M>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3104193 rs528453010	169	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA3104195 rs749852161	171	I>N		No	ClinGen ExAC gnomAD
CA107824807 rs945709645	174	R>*		No	ClinGen Ensembl
CA3104198 rs745945343	186	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1487793101 CA358433741	189	I>V		No	ClinGen gnomAD
TCGA novel	192	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA358433828 rs1238862299	193	I>T		No	ClinGen TOPMed
TCGA novel	196	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1162535661 CA358433928	197	I>M		No	ClinGen gnomAD
rs376663143 CA107825638	197	I>T		No	ClinGen ESP TOPMed gnomAD
CA107825626 rs1003985913	197	I>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA3104243 rs781597345	200	A>P		No	ClinGen ExAC TOPMed gnomAD
CA358433984 rs781597345	200	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA358434006 rs1561165883	201	C>G		No	ClinGen Ensembl
rs770679095 CA3104245	203	S>P		No	ClinGen ExAC gnomAD
rs1015733074 CA107825642	204	I>V		No	ClinGen TOPMed gnomAD
CA3104246 rs778753887	211	F>S		No	ClinGen ExAC gnomAD
rs772000940 CA3104248	212	V>F		No	ClinGen ExAC gnomAD
CA358434338 rs775345004	218	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1247162997 CA358434354	220	K>R		No	ClinGen gnomAD
CA358434360 rs1285690309	221	P>A		No	ClinGen gnomAD
TCGA novel	222	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1017987020 CA107825655	224	E>Q		No	ClinGen TOPMed
CA358434403 rs1477791117	225	L>F		No	ClinGen gnomAD
CA358434402 rs1462748216	225	L>W		No	ClinGen gnomAD
rs1171045851 CA358434405	226	G>R		No	ClinGen gnomAD
rs1431490228 CA358434425	229	M>L		No	ClinGen gnomAD
CA358434429 rs1323582317	229	M>T		No	ClinGen gnomAD
rs768200328 CA3104291	230	E>D		No	ClinGen ExAC gnomAD
CA3104292 rs747547636	231	L>V		No	ClinGen ExAC gnomAD
CA358434451 rs1442788984	232	H>L		No	ClinGen TOPMed gnomAD
rs769505078 CA3104293	234	E>D		No	ClinGen ExAC gnomAD
CA358434468 rs1299786476	235	G>R		No	ClinGen gnomAD
CA3104294 rs772695347	236	S>G		No	ClinGen ExAC gnomAD
CA358434475 rs1237039370	236	S>N		No	ClinGen TOPMed
rs766820318 CA3104296	237	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1409273901 CA358434485	237	S>R		No	ClinGen gnomAD
TCGA novel	238	S>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3104298 rs760108925	245	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA3104300 rs752826990	246	T>K		No	ClinGen ExAC TOPMed gnomAD
rs752826990 CA358434544	246	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1197501737 CA358434549	247	G>A		No	ClinGen TOPMed gnomAD
CA358434548 rs1197501737	247	G>D		No	ClinGen TOPMed gnomAD
CA358434550 rs1197501737	247	G>V		No	ClinGen TOPMed gnomAD
CA107825939 rs991718499	249	K>T		No	ClinGen Ensembl
rs1450856010 CA358434609	252	R>*		No	ClinGen gnomAD
rs1196964727 CA358434623	253	A>V		No	ClinGen gnomAD
CA107825944 rs1024483520	258	P>T		No	ClinGen Ensembl
CA3104302 rs764395706	260	V>I		No	ClinGen ExAC TOPMed gnomAD
CA358434727 rs1390777945	261	Q>E		No	ClinGen TOPMed
CA107825953 rs11548526	263	S>F		No	ClinGen Ensembl

No associated diseases with P61247

1 regional properties for P61247

Type	Name	Position	InterPro Accession
conserved_site	Ribosomal protein S3Ae, conserved site	62 - 74	IPR018281

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Nucleus, nucleolus	Localized in cytoplasmic mRNP granules containing untranslated mRNAs
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic ribosome	A ribosome located in the cytosol.
cytosolic small ribosomal subunit	The small subunit of a ribosome located in the cytosol.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

3 GO annotations of molecular function

Name	Definition
mRNA 5'-UTR binding	Binding to an mRNA molecule at its 5' untranslated region.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

5 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	Homo sapiens (Human)	PR
P97351	Rps3a	40S ribosomal protein S3a	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAVGKNKRLT	KGGKKGAKKK	VVDPFSKKDW	YDVKAPAMFN	IRNIGKTLVT	RTQGTKIASD
70	80	90	100	110	120
GLKGRVFEVS	LADLQNDEVA	FRKFKLITED	VQGKNCLTNF	HGMDLTRDKM	CSMVKKWQTM
130	140	150	160	170	180
IEAHVDVKTT	DGYLLRLFCV	GFTKKRNNQI	RKTSYAQHQQ	VRQIRKKMME	IMTREVQTND
190	200	210	220	230	240
LKEVVNKLIP	DSIGKDIEKA	CQSIYPLHDV	FVRKVKMLKK	PKFELGKLME	LHGEGSSSGK
250	260
ATGDETGAKV	ERADGYEPPV	QESV