P92969

PR
Gene name
RS41 (RSP41, At5g52040, MSG15.12)
Protein name
DNA-directed RNA polymerase 1, mitochondrial
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G68990
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P92969

Entry ID Method Resolution Chain Position Source
AF-P92969-F1 Predicted AlphaFoldDB

63 variants for P92969

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14451000 14 V>I No 1000Genomes
tmp_1_25940712_T_A 15 K>M No 1000Genomes
tmp_1_25940710_A_C 16 F>V No 1000Genomes
tmp_1_25940680_G_T 26 H>N No 1000Genomes
ENSVATH00132365 27 Y>F No 1000Genomes
ENSVATH05105100 34 G>R No 1000Genomes
ENSVATH14450999 39 V>L No 1000Genomes
ENSVATH13771143 40 N>K No 1000Genomes
ENSVATH13771142 50 I>R No 1000Genomes
tmp_1_25940569_G_A 63 R>C No 1000Genomes
tmp_1_25940551_C_T 69 V>M No 1000Genomes
tmp_1_25940139_G_A 206 P>L No 1000Genomes
ENSVATH13771141 208 M>L No 1000Genomes
ENSVATH05105097 232 A>T No 1000Genomes
ENSVATH05105094 263 K>E No 1000Genomes
tmp_1_25939823_T_C 263 K>R No 1000Genomes
ENSVATH14450996 264 K>R No 1000Genomes
ENSVATH13771129 265 N>K No 1000Genomes
tmp_1_25939817_T_G 265 N>T No 1000Genomes
tmp_1_25939802_G_A 270 T>I No 1000Genomes
ENSVATH01504364 274 I>T No 1000Genomes
ENSVATH13771128 277 E>D No 1000Genomes
ENSVATH01504363 279 E>V No 1000Genomes
ENSVATH01504362 280 N>H No 1000Genomes
ENSVATH01504361 281 V>A No 1000Genomes
ENSVATH13771127 291 E>K No 1000Genomes
ENSVATH01504359 308 Q>E No 1000Genomes
ENSVATH14450995 316 H>Y No 1000Genomes
ENSVATH05105092 327 Q>H No 1000Genomes
tmp_1_25939453_G_A 348 A>V No 1000Genomes
tmp_1_25939375_G_A 374 T>I No 1000Genomes
tmp_1_25938561_T_A 467 I>L No 1000Genomes
tmp_1_25938549_C_A 471 V>L No 1000Genomes
ENSVATH14450961 485 I>F No 1000Genomes
ENSVATH05105083 497 P>T No 1000Genomes
ENSVATH01504342 498 E>V No 1000Genomes
ENSVATH13771115 505 Q>H No 1000Genomes
tmp_1_25938085_A_C 548 F>V No 1000Genomes
ENSVATH14450959 599 I>V No 1000Genomes
tmp_1_25937893_A_G 612 Y>H No 1000Genomes
ENSVATH01504340 621 S>R No 1000Genomes
ENSVATH05105078 623 L>F No 1000Genomes
ENSVATH00132343 635 E>A No 1000Genomes
ENSVATH05105077 668 A>T No 1000Genomes
ENSVATH13771110 687 A>T No 1000Genomes
ENSVATH14450956 715 A>V No 1000Genomes
tmp_1_25937186_T_A 723 Q>L No 1000Genomes
tmp_1_25937163_C_T 731 E>K No 1000Genomes
ENSVATH00132334 731 E>V No 1000Genomes
tmp_1_25937145_T_C 737 T>A No 1000Genomes
tmp_1_25937130_T_C 742 M>V No 1000Genomes
tmp_1_25936466_T_C 827 N>S No 1000Genomes
tmp_1_25936448_G_A 833 T>M No 1000Genomes
ENSVATH05105061 870 A>V No 1000Genomes
tmp_1_25935942_T_C 898 N>S No 1000Genomes
tmp_1_25935936_G_A,T 900 A>D No 1000Genomes
tmp_1_25935936_G_A,T 900 A>V No 1000Genomes
ENSVATH01504290 920 V>I No 1000Genomes
ENSVATH14450899 924 I>T No 1000Genomes
ENSVATH01504289 924 I>V No 1000Genomes
tmp_1_25935744_T_C 935 K>E No 1000Genomes
tmp_1_25935593_T_A 946 Q>L No 1000Genomes
tmp_1_25935590_T_G 947 K>T No 1000Genomes

No associated diseases with P92969

2 regional properties for P92969

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, N-terminal 137 - 462 IPR029262
domain DNA-directed RNA polymerase, C-terminal domain, phage-type 585 - 976 IPR046950

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial DNA-directed RNA polymerase complex A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

1 GO annotations of biological process

Name Definition
mitochondrial transcription The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O24600 RPOT3 DNA-directed RNA polymerase 3, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MWRNILGRAS LRKVKFLSDS SSSGTHYPVN RVRGILSSVN LSGVRNGLSI NPVNEMGGLS
70 80 90 100 110 120
SFRHGQCYVF EGYATAAQAI DSTDPEDESS GSDEVNELIT EMEKETERIR KKARLAAIPP
130 140 150 160 170 180
KRVIAGMGAQ KFYMLKQRQV KMETEEWERA ARECREILAD MCEQKLAPNL PYMKSLFLGW
190 200 210 220 230 240
FEPVRNAIQD DLDTFKIKKG KIPYAPFMEQ LPADKMAVIT MHKMMGLLMT NAEGVGIVKL
250 260 270 280 290 300
VNAATQIGEA VEQEVRINSF LQKKNKKNAT DKTINTEAEN VSEEIVAKET EKARKQVTVL
310 320 330 340 350 360
MEKNKLRQVK ALVRKHDSFK PWGQEAQVKV GARLIQLLME NAYIQPPAEQ FDDGPPDIRP
370 380 390 400 410 420
AFKQNFRTVT LENTKTSRRY GCIECDPLVL KGLDKSARHM VIPYLPMLIP PQNWTGYDQG
430 440 450 460 470 480
AHFFLPSYVM RTHGAKQQRT VMKRTPKEQL EPVYEALDTL GNTKWKINKK VLSLVDRIWA
490 500 510 520 530 540
NGGRIGGLVD REDVPIPEEP EREDQEKFKN WRWESKKAIK QNNERHSQRC DIELKLEVAR
550 560 570 580 590 600
KMKDEEGFYY PHNVDFRGRA YPIHPYLNHL GSDLCRGILE FCEGKPLGKS GLRWLKIHIA
610 620 630 640 650 660
NLYAGGVDKL AYEDRIAFTE SHLEDIFDSS DRPLEGKRWW LNAEDPFQCL AACINLSEAL
670 680 690 700 710 720
RSPFPEAAIS HIPIHQDGSC NGLQHYAALG RDKLGADAVN LVTGEKPADV YTEIAARVLK
730 740 750 760 770 780
IMQQDAEEDP ETFPNATYAK LMLDQVDRKL VKQTVMTSVY GVTYSGARDQ IKKRLKERGT
790 800 810 820 830 840
FEDDSLTFHA SCYAAKITLK ALEEMFEAAR AIKSWFGDCA KIIASENNAV CWTTPLGLPV
850 860 870 880 890 900
VQPYRKPGRH LVKTTLQVLT LSRETDKVMA RRQMTAFAPN FIHSLDGSHM MMTAVACNRA
910 920 930 940 950 960
GLSFAGVHDS FWTHACDVDV MNTILREKFV ELYEKPILEN LLESFQKSFP DISFPPLPER
970
GDFDLRKVLE STYFFN