O24600
PR
Gene name |
RPOT3 |
Protein name |
DNA-directed RNA polymerase 3, chloroplastic |
Names |
Protein SCABRA 3 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G24120 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O24600
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O24600-F1 | Predicted | AlphaFoldDB |
42 variants for O24600
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_2_10254479_G_T | 18 | H>N | No | 1000Genomes | |
| ENSVATH05573587 | 27 | T>I | No | 1000Genomes | |
| ENSVATH00244305 | 28 | W>C | No | 1000Genomes | |
| ENSVATH05573586 | 31 | P>T | No | 1000Genomes | |
| ENSVATH13366386 | 36 | A>P | No | 1000Genomes | |
| ENSVATH13366385 | 61 | S>C | No | 1000Genomes | |
| ENSVATH13366374 | 66 | S>P | No | 1000Genomes | |
| ENSVATH05573585 | 103 | S>R | No | 1000Genomes | |
| ENSVATH00244303 | 106 | E>D | No | 1000Genomes | |
| ENSVATH13366372 | 140 | S>G | No | 1000Genomes | |
| ENSVATH14541491 | 305 | K>N | No | 1000Genomes | |
| tmp_2_10253460_C_G | 332 | S>T | No | 1000Genomes | |
| tmp_2_10252683_G_T | 435 | D>E | No | 1000Genomes | |
| ENSVATH13366334 | 494 | R>M | No | 1000Genomes | |
| tmp_2_10252174_A_T | 527 | S>T | No | 1000Genomes | |
| ENSVATH05573568 | 532 | A>V | No | 1000Genomes | |
| ENSVATH01880316 | 538 | I>T | No | 1000Genomes | |
| tmp_2_10251983_G_T | 561 | D>E | No | 1000Genomes | |
| tmp_2_10251873_A_T | 598 | F>Y | No | 1000Genomes | |
| tmp_2_10251852_C_T | 605 | G>E | No | 1000Genomes | |
| ENSVATH05573564 | 634 | A>G | No | 1000Genomes | |
| ENSVATH14541489 | 637 | E>K | No | 1000Genomes | |
| ENSVATH05573563 | 639 | H>R | No | 1000Genomes | |
| ENSVATH13366327 | 674 | T>A | No | 1000Genomes | |
| tmp_2_10251632_T_A | 678 | K>N | No | 1000Genomes | |
| tmp_2_10251619_A_C | 683 | Y>D | No | 1000Genomes | |
| tmp_2_10250949_T_G | 748 | E>A | No | 1000Genomes | |
| ENSVATH13366325 | 749 | S>T | No | 1000Genomes | |
| ENSVATH13366314 | 754 | A>V | No | 1000Genomes | |
| ENSVATH07893590 | 799 | T>N | No | 1000Genomes | |
| ENSVATH05573549 | 825 | A>P | No | 1000Genomes | |
| tmp_2_10250176_G_A | 884 | T>M | No | 1000Genomes | |
| tmp_2_10250002_C_T | 915 | R>Q | No | 1000Genomes | |
| ENSVATH13366305 | 953 | P>L | No | 1000Genomes | |
| tmp_2_10249461_T_C | 960 | Q>R | No | 1000Genomes | |
| ENSVATH05573531 | 961 | S>G | No | 1000Genomes | |
| ENSVATH13366290 | 966 | Y>N | No | 1000Genomes | |
| tmp_2_10249420_C_A | 974 | V>L | No | 1000Genomes | |
| ENSVATH00244290 | 976 | K>T | No | 1000Genomes | |
| tmp_2_10249399_C_G | 981 | D>H | No | 1000Genomes | |
| ENSVATH14541470 | 983 | K>E | No | 1000Genomes | |
| ENSVATH01880299 | 989 | Q>K | No | 1000Genomes |
No associated diseases with O24600
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chloroplast | A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. |
| mitochondrial DNA-directed RNA polymerase complex | A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial transcription | The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P92969 | RS41 | DNA-directed RNA polymerase 1, mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASAAAASPS | LSLNPTSHFQ | HQTSLVTWLK | PPPSSALFRR | KTLPFFERHS | LPISASSSSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SSSSTSLSVH | EKPISNSVHF | HGNLIESFEN | QDSSYAGTIK | GASLIEELEN | PVERNGLSGR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RRLFMQDPPW | ISALFLKGLS | KMVDQTLKIE | RKDIDKRKFD | SLRRRQVKEE | TEAWERMVDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YRDLEKEMCE | KNLAPNLPYV | KHMFLGWFQP | LKDVIEREQK | LQKNKSKKVR | AAYAPHIELL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PADKMAVIVM | HKMMGLVMSG | HEDGCIQVVQ | AAVSIGIAIE | QEVRIHNFLK | RTRKNNAGDS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QEELKEKQLL | RKRVNSLIRR | KRIIDALKVV | KSEGTKPWGR | ATQAKLGSRL | LELLIEAAYV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QPPLTQSGDS | IPEFRPAFRH | RFKTVTKYPG | SKLVRRYGVI | ECDSLLLAGL | DKSAKHMLIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YVPMLVPPKR | WKGYDKGGYL | FLPSYIMRTH | GSKKQQDALK | DISHKTAHRV | FEALDTLGNT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KWRVNRNILD | VVERLWADGG | NIAGLVNRED | VPIPEKPSSE | DPEELQSWKW | SARKANKINR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ERHSLRCDVE | LKLSVARKMK | DEEGFYYPHN | LDFRGRAYPM | HPHLNHLSSD | LCRGTLEFAE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GRPLGKSGLH | WLKIHLANLY | AGGVEKLSHD | ARLAFVENHL | DDIMDSAENP | IHGKRWWLKA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EDPFQCLAAC | VILTQALKSP | SPYSVISHLP | IHQDGSCNGL | QHYAALGRDS | FEAAAVNLVA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GEKPADVYSE | ISRRVHEIMK | KDSSKDPESN | PTAALAKILI | TQVDRKLVKQ | TVMTSVYGVT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YVGAREQIKR | RLEEKGVITD | ERMLFAAACY | SAKVTLAALG | EIFEAARAIM | SWLGDCAKII |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ASDNHPVRWI | TPLGLPVVQP | YCRSERHLIR | TSLQVLALQR | EGNTVDVRKQ | RTAFPPNFVH |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SLDGTHMMMT | AVACREAGLN | FAGVHDSYWT | HACDVDTMNR | ILREKFVELY | NTPILEDLLQ |
| 970 | 980 | 990 | |||
| SFQESYPNLV | FPPVPKRGDF | DLKEVLKSQY | FFN |