P86049
Gene name |
Rbm46 |
Protein name |
Probable RNA-binding protein 46 |
Names |
RNA-binding motif protein 46 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:633285 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P86049
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P86049-F1 | Predicted | AlphaFoldDB |
16 variants for P86049
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388631820 | 87 | I>L | No | EVA | |
| rs3388633441 | 107 | M>I | No | EVA | |
| rs3388624905 | 124 | Y>H | No | EVA | |
| rs3388638423 | 130 | K>E | No | EVA | |
| rs3388631753 | 132 | I>S | No | EVA | |
| rs3388638502 | 230 | E>V | No | EVA | |
| rs3388624952 | 282 | E>V | No | EVA | |
| rs3388624943 | 295 | C>* | No | EVA | |
| rs3393277654 | 307 | K>* | No | EVA | |
| rs3393268073 | 307 | K>M | No | EVA | |
| rs223477033 | 390 | H>Q | No | EVA | |
| rs3393263886 | 403 | N>K | No | EVA | |
| rs3393308535 | 403 | N>S | No | EVA | |
| rs3393238083 | 406 | N>D | No | EVA | |
| rs3388633360 | 470 | N>I | No | EVA | |
| rs32717637 | 515 | A>T | No | EVA |
No associated diseases with P86049
6 regional properties for P86049
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 61 - 139 | IPR000504-1 |
| domain | RNA recognition motif domain | 141 - 223 | IPR000504-2 |
| domain | RNA recognition motif domain | 236 - 308 | IPR000504-3 |
| domain | Probable RNA-binding protein 46, RNA recognition motif 1 | 60 - 137 | IPR034434 |
| domain | Probable RNA-binding protein 46, RNA recognition motif 2 | 139 - 223 | IPR034435 |
| domain | RBM46, double-stranded RNA binding domain | 393 - 470 | IPR044462 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA stabilization | Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. |
| trophectodermal cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A0AV96 | RBM47 | RNA-binding protein 47 | Homo sapiens (Human) | PR |
| Q8TBY0 | RBM46 | Probable RNA-binding protein 46 | Homo sapiens (Human) | PR |
| Q9CR83 | Rbm18 | Probable RNA-binding protein 18 | Mus musculus (Mouse) | PR |
| Q0P4R6 | rbm46 | Probable RNA-binding protein 46 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNEENTDGTN | GCSKVRTGTQ | NEAALLALME | KTGYNMVQEN | GQRKFGGPPP | GWEGPPPPRG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CEVFVGKIPR | DMYEDELVPV | FERAGKIYEF | RLMMEFSGEN | RGYAFVMYTT | KEEAQLAIRI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNNYEIRPGK | FIGVCVSLDN | CRLFIGAIPK | EKKKEEILDE | MKKVTEGVVD | VIVYPSATDK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TKNRGFAFVE | YESHRAAAMA | RRKLIPGTFQ | LWGHTIQVDW | ADPEKEVDEE | TMQRVKVLYV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RNLMISTTEE | TIKAEFSKFK | PGAVERVKKL | RDYAFVHFFH | REDAVAAMSV | MNGKCIDGAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IEVTLAKPVN | KENTWRQHLN | GQISPNSENL | LVYANKEESH | SKSLGKPPTL | PTRLNGQHSP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPPEIERCTY | PFFPGTKLTP | ISMYSLKSNH | FNSAVMHLDY | YCNKNNWAPP | EYYLYSTTSQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DGKVLLVYKI | VIPAIANGSQ | SYFMPDKLCT | TLEDAKELAA | QFTLLHLDFN | FRRSSINSLS |
| 490 | 500 | 510 | 520 | 530 | |
| PVSTTLSSGT | PSMLPYTSRP | SSYPSYPLSP | TISLANGSHV | GQRLYISNQA | SFF |