P85094

PR
Gene name
Isoc2a
Protein name
Isochorismatase domain-containing protein 2A
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:664994
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

160-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P85094

Entry ID Method Resolution Chain Position Source
AF-P85094-F1 Predicted AlphaFoldDB

9 variants for P85094

Variant ID(s) Position Change Description Diseaes Association Provenance
rs257651679 7 S>G No EVA
rs3388856457 20 L>I No EVA
rs3388872855 46 K>N No EVA
rs3388837924 62 P>R No EVA
rs3388872850 64 G>D No EVA
rs3388859049 86 S>C No EVA
rs3388869652 109 I>N No EVA
rs3388877017 175 P>S No EVA
rs222199584 195 S>G No EVA

No associated diseases with P85094

1 regional properties for P85094

Type Name Position InterPro Accession
domain Isochorismatase-like 16 - 162 IPR000868

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Localizes to the nucleus in the presence of CDKN2A
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
protein destabilization Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32KX0 ISOC2 Isochorismatase domain-containing protein 2 Bos taurus (Bovine) PR
Q5U3Z3 Isoc2 Isochorismatase domain-containing protein 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAAARASLGR ILPESSILFL CDLQEKFRPS IAYFPQIVSV AARMLKVARL LDVPILLTEQ
70 80 90 100 110 120
YPEGLGPTVP ELGAQGIRPV SKTCFSMVPA LQKELDGRSQ LQSVLLCGIE TQACILNTAL
130 140 150 160 170 180
DLLHRGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLAT SESLILQLVR DASHPQFKEI
190 200
QKIIKEPVPD SGLLSLFQGQ SPLTSC