AiPD: Autoinhibited Protein Database

P83111

Gene name	LACTB
Protein name	Serine beta-lactamase-like protein LACTB, mitochondrial
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:114294
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-133 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-133 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for P83111

Entry ID	Method	Resolution	Chain	Position	Source
7ULW	EM	310 A	A/B/C/D/E/F	97-547	PDB
7V1Y	EM	282 A	A/B/C/D	63-547	PDB
7V1Z	EM	298 A	A/B/C/D	63-547	PDB
7V21	EM	308 A	A/B/C/D	63-547	PDB
AF-P83111-F1	Predicted				AlphaFoldDB

451 variants for P83111

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA392719283 rs1318497200	2	Y>*		No	ClinGen gnomAD
rs745611187 CA7601219	2	Y>F		No	ClinGen ExAC gnomAD
rs1260013052 CA392719289	3	R>Q		No	ClinGen gnomAD
rs771795019 CA392719288	3	R>W		No	ClinGen ExAC TOPMed gnomAD
rs775466256 CA392719296	4	L>F		No	ClinGen ExAC gnomAD
CA7601221 rs775466256	4	L>I		No	ClinGen ExAC gnomAD
CA392719312 CA7601223 rs556450517	5	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs34317102 CA392719305 CA7601222	5	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392719308 rs1453922185	5	M>T		No	ClinGen gnomAD
CA392719303 rs34317102	5	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1410523635 CA392719320 CA392719319	6	S>*		No	ClinGen gnomAD
CA392719322 rs1410523635	6	S>L		No	ClinGen gnomAD
rs776188282 CA7601224	7	A>E		No	ClinGen ExAC gnomAD
CA392719346 rs1350934455	9	T>A		No	ClinGen gnomAD
CA392719361 rs1368111153	10	A>D		No	ClinGen gnomAD
rs1324528387 CA392719357	10	A>T		No	ClinGen gnomAD
CA392719364 rs1368111153	10	A>V		No	ClinGen gnomAD
CA7601225 rs761314159	11	R>G		No	ClinGen ExAC gnomAD
CA272039337 rs1019486651	11	R>Q		No	ClinGen TOPMed gnomAD
rs761314159 CA392719368	11	R>W		No	ClinGen ExAC gnomAD
rs1595712120 CA392719379	12	A>G		No	ClinGen Ensembl
CA7601226 rs764809586	12	A>T		No	ClinGen ExAC gnomAD
CA7601227 rs750094530	13	A>T		No	ClinGen ExAC TOPMed gnomAD
CA392719389 rs1215464278	13	A>V		No	ClinGen gnomAD
CA7601229 rs767825159	14	A>D		No	ClinGen ExAC TOPMed gnomAD
CA392719408 rs1468824714	15	P>H		No	ClinGen gnomAD
rs1234763364 CA392719403	15	P>T		No	ClinGen gnomAD
RCV000957298 CA210225 RCV000201410 CA7601230 rs34925488	16	G>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7601232 rs778350908	17	G>D		No	ClinGen ExAC gnomAD
CA7601231 rs139879323	17	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7601233 rs753912650	21	S>G		No	ClinGen ExAC TOPMed gnomAD
rs757436737 CA392719482	21	S>N		No	ClinGen ExAC gnomAD
CA7601234 rs757436737	21	S>T		No	ClinGen ExAC gnomAD
TCGA novel	24	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs34297800 CA7601235 RCV000957299	25	R>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7601236 rs34297800	25	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs926506385 CA272039425	27	V>I		No	ClinGen TOPMed
CA392719540 rs1439603440	30	R>C		No	ClinGen gnomAD
CA392719557 rs1048982587	33	L>V		No	ClinGen TOPMed
CA7601238 rs779768860	34	P>R		No	ClinGen ExAC TOPMed gnomAD
CA392719561 rs1409806641	34	P>T		No	ClinGen TOPMed
CA392719581 rs1334088859	37	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA392719579 rs1291347840	37	G>R		No	ClinGen TOPMed gnomAD
CA392719578 rs1291347840	37	G>S		No	ClinGen TOPMed gnomAD
CA392719588 rs1487375349	38	H>R		No	ClinGen TOPMed
CA392719604 CA7601240 rs768408264	40	W>C		No	ClinGen ExAC TOPMed gnomAD
rs1275231905 CA392719598	40	W>R		No	ClinGen gnomAD
CA272039456 rs908723529	41	V>G		No	ClinGen Ensembl
rs1330668515 CA392719641	47	G>R		No	ClinGen TOPMed
CA272039474 rs1040216846	51	A>S		No	ClinGen TOPMed gnomAD
rs1417685394 CA392719665	51	A>V		No	ClinGen gnomAD
CA392719667 rs1454778096	52	L>I		No	ClinGen gnomAD
CA272039502 rs901669698	53	G>A		No	ClinGen gnomAD
CA392719674 rs901669698	53	G>E		No	ClinGen gnomAD
rs761260684 CA7601242 CA392719673	53	G>R		No	ClinGen ExAC TOPMed gnomAD
rs761260684 CA272039497	53	G>W		No	ClinGen ExAC TOPMed gnomAD
CA392719679 rs1595712251	54	V>A		No	ClinGen Ensembl
rs1009327150 CA272039503	57	A>G		No	ClinGen Ensembl
CA272039504 rs1009327150	57	A>V		No	ClinGen Ensembl
CA392719707 rs1421003653	59	G>R		No	ClinGen gnomAD
CA392719716 rs1455519051	61	R>G		No	ClinGen TOPMed
rs1566988356 CA392719731	63	A>P		No	ClinGen Ensembl
rs1021095638 CA272039509	63	A>V		No	ClinGen Ensembl
rs769320798 CA7601243	64	A>G		No	ClinGen ExAC TOPMed gnomAD
CA272039517 rs1008166998	65	P>L		No	ClinGen TOPMed
TCGA novel	66	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA272039550 rs966582560	68	S>C		No	ClinGen TOPMed gnomAD
rs966582560 CA392719761	68	S>F		No	ClinGen TOPMed gnomAD
rs1000558324 CA272039548	68	S>P		No	ClinGen Ensembl
CA7601245 rs762573699	70	A>E		No	ClinGen ExAC gnomAD
rs772833685 CA7601244	70	A>T		No	ClinGen ExAC gnomAD
CA392719774 rs1337522339	71	A>S		No	ClinGen gnomAD
CA392719777 rs1214119006	71	A>V		No	ClinGen gnomAD
CA272039559 rs1033334829	72	P>L		No	ClinGen gnomAD
rs1434681792 CA392719779	72	P>T		No	ClinGen gnomAD
rs1209124514 CA392719783	73	D>N		No	ClinGen gnomAD
rs1257289041 CA392719791	74	P>T		No	ClinGen gnomAD
CA392719800 rs1595712310	75	E>A		No	ClinGen Ensembl
CA272039573 rs992409261	77	S>*		No	ClinGen Ensembl
CA272039568 rs959647146	77	S>T		No	ClinGen TOPMed gnomAD
rs1240934900 CA392719822	79	L>V		No	ClinGen TOPMed gnomAD
rs1465997745 CA392719826	80	A>T		No	ClinGen TOPMed
CA392719831 rs1371217657	80	A>V		No	ClinGen gnomAD
rs1474135633 CA392719832	81	E>K		No	ClinGen TOPMed gnomAD
rs1231666157 CA392719858	84	Q>H		No	ClinGen TOPMed
rs1258352731 CA392719856	84	Q>L		No	ClinGen TOPMed
TCGA novel	84	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1330933766 CA392719877	87	S>P		No	ClinGen TOPMed
CA392719890 rs1395243046	89	A>S		No	ClinGen gnomAD
rs1566988427 CA392719893	89	A>V		No	ClinGen Ensembl
CA392719898 rs767923145	90	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7601246 rs767923145	90	P>R		No	ClinGen ExAC TOPMed gnomAD
CA7601248 rs761116317	92	S>F		No	ClinGen ExAC gnomAD
CA392719914 rs1320187078	93	P>A		No	ClinGen gnomAD
CA392719918 rs1324631782	93	P>R		No	ClinGen gnomAD
CA392719913 rs1320187078	93	P>T		No	ClinGen gnomAD
CA272039655 rs931376974	95	T>N		No	ClinGen TOPMed gnomAD
CA272039684 rs943328168	96	P>L		No	ClinGen TOPMed gnomAD
CA272039683 rs943328168	96	P>Q		No	ClinGen TOPMed gnomAD
rs757381709 CA272039675	96	P>S		No	ClinGen ExAC gnomAD
rs757381709 CA7601251	96	P>T		No	ClinGen ExAC gnomAD
CA392719939 rs1354862239	97	A>E		No	ClinGen gnomAD
CA392719937 rs1354862239	97	A>V		No	ClinGen gnomAD
rs1282705282 CA392719948	99	P>S		No	ClinGen gnomAD
CA7601253 rs750643781	101	S>C		No	ClinGen ExAC TOPMed gnomAD
rs992430035 CA272039723	103	C>W		No	ClinGen TOPMed
rs780326976 CA7601255	103	C>Y		No	ClinGen ExAC gnomAD
rs1319732758 CA392719988	105	A>S		No	ClinGen TOPMed gnomAD
rs917770897 CA272039734	105	A>V		No	ClinGen TOPMed
CA7601256 rs746721789	106	R>G		No	ClinGen ExAC gnomAD
CA7601258 rs781063730	107	A>T		No	ClinGen ExAC gnomAD
rs1160089168 CA392720151	108	I>F		No	ClinGen TOPMed gnomAD
rs1400065234 CA392720155	108	I>M		No	ClinGen TOPMed gnomAD
CA392720154 rs1382642791	108	I>S		No	ClinGen gnomAD
CA392720153 rs1382642791	108	I>T		No	ClinGen gnomAD
rs748119566 CA7601259	109	E>V		No	ClinGen ExAC gnomAD
CA392720164 rs1396751227	110	S>G		No	ClinGen gnomAD
CA392720174 rs1344931866	111	S>N		No	ClinGen TOPMed
CA392720187 rs1302936074	113	D>Y		No	ClinGen gnomAD
CA392720207 rs748838431	116	H>L		No	ClinGen ExAC gnomAD
CA7601262 rs748838431	116	H>R		No	ClinGen ExAC gnomAD
CA272039777 rs201581882	117	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201581882 CA7601263	117	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1214827658 CA392720217	118	I>V		No	ClinGen gnomAD
rs1236422103 CA392720223	119	K>E		No	ClinGen gnomAD
rs1275670265 CA392720228	119	K>N		No	ClinGen TOPMed gnomAD
CA392720256 rs1368705030	122	V>M		No	ClinGen TOPMed
CA7601291 rs553328061	123	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA392720279 rs1229053497	126	G>S		No	ClinGen gnomAD
CA7601294 rs775511153	127	I>L		No	ClinGen ExAC TOPMed gnomAD
rs1456599781 CA392720289	127	I>M		No	ClinGen TOPMed
CA272040331 rs775511153	127	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	129	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	131	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1595712790 CA392720313	131	V>G		No	ClinGen Ensembl
CA272040360 rs910930306	134	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA392720330 rs1211288563	134	D>V		No	ClinGen gnomAD
rs1259387551 CA392720336	135	G>E		No	ClinGen gnomAD
TCGA novel	137	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1458834497 CA392720373	140	S>*		No	ClinGen TOPMed
CA7601296 rs767735544	141	E>D		No	ClinGen ExAC gnomAD
rs1194766963 CA392721233	144	G>S		No	ClinGen TOPMed
CA7601313 rs759627744	144	G>V		No	ClinGen ExAC gnomAD
CA7601314 rs767680456	146	A>T		No	ClinGen ExAC gnomAD
rs1472079411 CA392721333	147	D>E		No	ClinGen gnomAD
rs752950180 CA7601315	147	D>V		No	ClinGen ExAC gnomAD
CA392721378 rs1347424920	149	E>D		No	ClinGen gnomAD
CA392721367 rs1444806023	149	E>Q		No	ClinGen TOPMed
rs760433188 CA7601316	151	R>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	152	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA272044169 rs528872860	152	V>I		No	ClinGen 1000Genomes
rs1387240178 CA392721439	153	P>A		No	ClinGen gnomAD
CA392721468 rs1419045863	154	C>W		No	ClinGen gnomAD
rs1261729823 CA392721471	155	K>E		No	ClinGen TOPMed
CA272044179 rs994505528	157	E>A		No	ClinGen gnomAD
CA392721489 rs1368336615	157	E>D		No	ClinGen gnomAD
CA392721487 rs994505528	157	E>G		No	ClinGen gnomAD
rs1223247483 CA392721496	158	T>I		No	ClinGen TOPMed
TCGA novel	160	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392721508 rs1218382630	160	M>T		No	ClinGen gnomAD
rs763998435 CA7601317	161	R>*		No	ClinGen ExAC TOPMed gnomAD
CA392721515 rs1318554352	161	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA272044196 rs141345466	163	A>V		No	ClinGen ESP
CA392721529 rs1213516285	164	S>G		No	ClinGen gnomAD
CA392721543 rs1428842499	166	S>R		No	ClinGen TOPMed
CA7601318 rs753707105	167	K>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	168	S>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	169	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1408206470 CA392721586	171	M>I		No	ClinGen TOPMed
CA392721579 rs1215652228	171	M>V		No	ClinGen TOPMed gnomAD
rs757284857 CA7601319	175	A>P		No	ClinGen ExAC gnomAD
rs1488296899 CA392721614	176	K>R		No	ClinGen TOPMed gnomAD
CA392721615 rs1488296899	176	K>T		No	ClinGen TOPMed gnomAD
rs778720573 CA7601320	177	L>V		No	ClinGen ExAC gnomAD
TCGA novel	181	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	185	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	187	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1020479854 CA272044293	188	P>L		No	ClinGen TOPMed gnomAD
rs753526102 CA7601322	188	P>S		No	ClinGen ExAC gnomAD
CA392721703 rs1327364159	189	V>A		No	ClinGen gnomAD
CA7601323 rs779810437	189	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1347702142 CA392721728	193	V>I		No	ClinGen gnomAD
CA7601324 rs746697600	195	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	197	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7601326 rs376443763	200	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA272044305 rs76611228	201	Y>*		No	ClinGen 1000Genomes gnomAD
rs1319073824 CA392721788	201	Y>C		No	ClinGen TOPMed
rs1260320609 CA392721796	202	E>G		No	ClinGen TOPMed
CA7601328 rs771415441	203	G>D		No	ClinGen ExAC gnomAD
CA7601327 rs749623514	203	G>R		No	ClinGen ExAC gnomAD
rs774864003 CA7601329	205	K>N		No	ClinGen ExAC
CA392721833 rs1416524119	206	V>A		No	ClinGen gnomAD
CA392721853 rs1291411758	210	T>A		No	ClinGen gnomAD
rs368829983 CA7601343	211	R>G		No	ClinGen ESP ExAC gnomAD
rs766032294 CA7601344	211	R>I		No	ClinGen ExAC gnomAD
CA392721863 rs751240045	211	R>S		No	ClinGen ExAC TOPMed gnomAD
rs754596627 CA7601346	213	L>P		No	ClinGen ExAC gnomAD
CA7601347 rs780725423	216	H>Q		No	ClinGen ExAC gnomAD
CA392721934 COSM963664 rs1486880436	221	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs142422927 CA7601348	221	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs755533365 CA272044559	222	H>P		No	ClinGen gnomAD
CA392721948 rs755533365	222	H>R		No	ClinGen gnomAD
CA7601349 rs757597249	223	Y>D		No	ClinGen ExAC gnomAD
CA7601350 rs779362563	223	Y>S		No	ClinGen ExAC gnomAD
TCGA novel	224	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746424994 CA7601351	225	K>N		No	ClinGen ExAC gnomAD
CA7601352 rs772125791	228	K>E		No	ClinGen ExAC TOPMed gnomAD
CA392722096 rs1339821752	233	E>K		No	ClinGen TOPMed gnomAD
CA392722097 rs1339821752	233	E>Q		No	ClinGen TOPMed gnomAD
CA392722129 rs1291212766	235	A>D		No	ClinGen TOPMed
CA7601355 rs768865373	235	A>T		No	ClinGen ExAC TOPMed gnomAD
rs776738955 CA7601356	236	Y>H		No	ClinGen ExAC gnomAD
CA392722161 rs1227904284	238	A>T		No	ClinGen gnomAD
CA392722168 rs1304528542	238	A>V		No	ClinGen gnomAD
CA7601357 rs761627317	239	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1317496435 CA392722195	240	K>R		No	ClinGen TOPMed
CA7601358 rs765161553	241	M>I		No	ClinGen ExAC gnomAD
CA7601359 rs773258779	242	M>K		No	ClinGen ExAC TOPMed gnomAD
CA272044614 rs930437390	243	K>Q		No	ClinGen TOPMed
CA272044615 rs113115012	245	N>S		No	ClinGen Ensembl
TCGA novel	247	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7601360 rs763038053	249	E>K		No	ClinGen ExAC gnomAD
rs763038053 CA392722390	249	E>Q		No	ClinGen ExAC gnomAD
CA7601361 rs765980175	250	Q>E		No	ClinGen ExAC gnomAD
rs984588886 CA272044640	251	E>Q		No	ClinGen TOPMed gnomAD
rs751058328 CA7601362	252	K>R		No	ClinGen ExAC gnomAD
TCGA novel	253	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1595714841 CA392722491	253	E>K		No	ClinGen Ensembl
rs754471151 CA7601363	254	G>V		No	ClinGen ExAC gnomAD
CA7601364 rs34536322	255	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs752336094 CA7601365	255	K>R		No	ClinGen ExAC gnomAD
CA272044691 rs966323504	256	S>N		No	ClinGen Ensembl
rs750803911 CA272044703	257	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1401193349 CA618954928	259	K>N		No	ClinGen gnomAD
rs779309517 CA7601368	259	K>N		No	ClinGen ExAC
rs1566990528 CA392722627	259	K>T		No	ClinGen Ensembl
rs746371664 CA7601369	260	N>K		No	ClinGen ExAC
rs758834671 CA7601370	261	D>N		No	ClinGen ExAC gnomAD
CA392722655 rs1386537785	261	D>V		No	ClinGen gnomAD
CA392722648 rs758834671	261	D>Y		No	ClinGen ExAC gnomAD
CA7601371 rs780550541	262	F>V		No	ClinGen ExAC gnomAD
CA392722679 rs1486870661	264	K>R		No	ClinGen gnomAD
CA7601373 rs182421897	265	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA272044798 rs140622762	267	T>A		No	ClinGen ESP TOPMed gnomAD
rs896127135 CA272044807	267	T>K		No	ClinGen TOPMed gnomAD
rs748363340 CA7601375	268	E>K		No	ClinGen ExAC gnomAD
CA272044813 rs535481475	269	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7601376 rs535481475	269	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs773205311 CA7601377	270	E>A		No	ClinGen ExAC gnomAD
rs375272227 CA272044815	270	E>D		No	ClinGen Ensembl
CA7601378 rs762857350	271	N>S		No	ClinGen ExAC gnomAD
rs1400570916 CA392722741	273	A>V		No	ClinGen TOPMed
CA7601381 rs201235539	276	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774191436 CA7601380	276	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7601382 rs766986822	277	N>Y		No	ClinGen ExAC gnomAD
CA272044925 rs531768271	279	K>E		No	ClinGen Ensembl
rs1160210142 CA392722805	283	K>R		No	ClinGen gnomAD
rs572687558 CA7601384	284	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs763742169 CA7601385	288	E>V		No	ClinGen ExAC gnomAD
rs1385287756 CA392722853	289	Q>H		No	ClinGen gnomAD
rs750727023 CA7601386	289	Q>K		No	ClinGen ExAC gnomAD
rs758783221 CA7601387	290	G>V		No	ClinGen ExAC gnomAD
COSM1373922 CA7601390 rs755059722	291	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA392722910 rs1595714928	297	K>N		No	ClinGen Ensembl
CA392722918 rs1486906885	298	F>L		No	ClinGen TOPMed
CA7601394 rs770071147	300	N>K		No	ClinGen ExAC gnomAD
CA392722937 rs1357893330	301	S>*		No	ClinGen gnomAD
rs142381405 CA7601397	302	I>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142381405 CA7601396	302	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	306	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392722967 rs1183728548	306	R>T		No	ClinGen gnomAD
CA392722971 rs1249478616	307	L>I		No	ClinGen gnomAD
rs1225087331 CA392723006	311	D>G		No	ClinGen TOPMed
CA392723012 rs1343308021	312	P>H		No	ClinGen TOPMed
CA272045016 rs926728684	312	P>S		No	ClinGen Ensembl
rs774327364 CA7601399	316	K>I		No	ClinGen ExAC TOPMed gnomAD
rs774327364 CA7601398	316	K>R		No	ClinGen ExAC TOPMed gnomAD
CA272045053 rs889186456	317	P>L		No	ClinGen TOPMed gnomAD
rs771607460 CA7601400	317	P>S		No	ClinGen ExAC gnomAD
rs199835006 CA7601412	318	G>A		No	ClinGen 1000Genomes ExAC gnomAD
rs146546670 CA7601413	319	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs111861955 CA272046497	319	S>N		No	ClinGen gnomAD
rs1281724293 CA392723496	319	S>R		No	ClinGen TOPMed gnomAD
rs1595715548 CA392723528	321	F>V		No	ClinGen Ensembl
rs778114499 CA7601414	322	L>F		No	ClinGen ExAC gnomAD
rs370595558 CA7601416	328	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA392723646 rs1186944065	328	Y>H		No	ClinGen gnomAD
CA392723684 rs1166988026	329	T>N		No	ClinGen gnomAD
rs1595715568 CA392723672	329	T>P		No	ClinGen Ensembl
CA7601419 rs139183549	332	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs775519108 CA7601420	333	A>G		No	ClinGen ExAC gnomAD
rs915088572 CA392723746	334	I>L		No	ClinGen TOPMed
rs915088572 CA272046549	334	I>V		No	ClinGen TOPMed
rs1261449932 CA392723768	335	V>I		No	ClinGen gnomAD
CA392723791 rs1400694052	336	E>A		No	ClinGen gnomAD
rs746480283 CA392723809	337	R>K		No	ClinGen ExAC TOPMed gnomAD
rs746480283 CA7601421	337	R>T		No	ClinGen ExAC TOPMed gnomAD
CA7601422 rs186932521	338	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA392723921 rs1453297412	343	Y>F		No	ClinGen gnomAD
rs930221220 CA272046575	346	Y>H		No	ClinGen gnomAD
CA7601426 rs533248895	347	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs368235977 CA392723999	348	Q>*		No	ClinGen gnomAD
rs368235977 CA272046594	348	Q>E		No	ClinGen gnomAD
CA7601427 rs759955286	348	Q>R		No	ClinGen ExAC gnomAD
rs1199898241 CA392724056	350	I>M		No	ClinGen gnomAD
rs1396651361 CA392724080	352	H>R		No	ClinGen TOPMed
CA7601430 rs756244410	358	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7601432 rs754109761	360	V>M		No	ClinGen ExAC gnomAD
rs1454926520 CA392724186	361	Q>*		No	ClinGen TOPMed gnomAD
rs1454926520 CA392724184	361	Q>E		No	ClinGen TOPMed gnomAD
rs757488085 CA7601433	362	E>K		No	ClinGen ExAC gnomAD
rs912011979 CA272046675	363	E>K		No	ClinGen gnomAD
CA7601434 rs779210852	364	N>D		No	ClinGen ExAC gnomAD
CA392724235 rs745599979	364	N>K		No	ClinGen ExAC TOPMed gnomAD
CA7601436 rs368633373	365	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1005141365 CA272046731	366	P>S		No	ClinGen TOPMed
CA7601437 rs779823983	367	V>M		No	ClinGen ExAC gnomAD
rs148264247 CA7601438	370	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7601462 rs777272720	375	Y>*		No	ClinGen ExAC gnomAD
rs1246443177 CA392725308	375	Y>C		No	ClinGen TOPMed
rs749030611 CA7601463	376	V>D		No	ClinGen ExAC gnomAD
CA392725404 rs1216816022 COSM963667	382	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs772322623 CA7601464	382	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1282311705 CA392725453	386	T>R		No	ClinGen TOPMed
rs1026377051 CA272056344	387	P>R		No	ClinGen TOPMed gnomAD
rs775930879 CA7601465	387	P>S		No	ClinGen ExAC gnomAD
rs1352977343 CA392725463	388	Y>N		No	ClinGen TOPMed
CA392725480 rs1238624473	389	V>E		No	ClinGen TOPMed gnomAD
CA7601467 rs566925626 COSM288441	389	V>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA7601468 rs777310393	390	D>H		No	ClinGen ExAC gnomAD
rs761766710 CA7601469	391	N>D		No	ClinGen ExAC gnomAD
CA392725503 rs1347758143	391	N>I		No	ClinGen gnomAD
CA392725515 rs1457182235	392	S>F		No	ClinGen gnomAD
rs765406619 CA7601470	394	K>N		No	ClinGen ExAC gnomAD
CA7601471 rs750598000	395	W>L		No	ClinGen ExAC gnomAD
CA392725559 rs1365248997	396	A>V		No	ClinGen TOPMed
rs1287723878 CA392725613	402	S>C		No	ClinGen TOPMed gnomAD
rs766589039 CA7601473	403	T>A		No	ClinGen ExAC gnomAD
rs1230115734 CA392725631	404	V>A		No	ClinGen gnomAD
rs1346572766 CA392725680	409	K>R		No	ClinGen TOPMed
CA392725724 rs1156366533	412	N>S		No	ClinGen TOPMed
rs754787506 CA7601475	413	A>V		No	ClinGen ExAC gnomAD
rs200127857 CA7601476 COSM216347	414	M>I	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA392725749 rs1418566096	414	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs752732965 CA7601477	415	L>F		No	ClinGen ExAC gnomAD
rs1482304544 CA392725780	416	Y>S		No	ClinGen gnomAD
CA7601478 rs755570176	417	G>C		No	ClinGen ExAC TOPMed gnomAD
rs966030279 CA272056425	417	G>D		No	ClinGen gnomAD
rs748753368 CA7601480	418	Y>H		No	ClinGen ExAC gnomAD
rs770651278 CA7601481 CA392725836	421	G>R		No	ClinGen ExAC TOPMed gnomAD
rs778731900 CA7601482	423	F>L		No	ClinGen ExAC gnomAD
rs1372171353 CA392725856	423	F>L		No	ClinGen gnomAD
CA392725908 rs1307276532	426	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7601483 rs747339663	427	N>D		No	ClinGen ExAC gnomAD
CA392725928 rs1216086833	429	N>S		No	ClinGen TOPMed
TCGA novel	430	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777253275 CA7601485	433	G>E		No	ClinGen ExAC gnomAD
CA392725959 rs1215356924	434	Y>C		No	ClinGen gnomAD
CA7601488 rs773272640	438	E>D		No	ClinGen ExAC gnomAD
CA7601489 rs144012110	439	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA392726000 rs1566994557	440	M>T		No	ClinGen Ensembl
CA392725997 rs1310337345	440	M>V		No	ClinGen TOPMed
rs766535919 CA7601490	441	V>F		No	ClinGen ExAC TOPMed gnomAD
rs766535919 CA392726006	441	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	442	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7601491 rs751809066	443	M>L		No	ClinGen ExAC
CA392726022 rs1281616840	443	M>T		No	ClinGen gnomAD
rs759306733 CA7601492	444	W>*		No	ClinGen ExAC gnomAD
CA392726058 rs1208693558	448	P>L		No	ClinGen gnomAD
CA392726070 rs1214927582	450	T>K		No	ClinGen TOPMed
CA392726078 rs1482676416	451	E>D		No	ClinGen gnomAD
rs767361464 CA7601493	451	E>K		No	ClinGen ExAC gnomAD
CA392726087 rs1188799070	452	M>I		No	ClinGen gnomAD
rs1033243434 CA272056539	452	M>V		No	ClinGen Ensembl
rs1363719580 CA392726107	455	D>G		No	ClinGen TOPMed
rs1391635467 CA392726117	456	K>N		No	ClinGen gnomAD
rs1161209543 CA392726125	457	E>D		No	ClinGen gnomAD
rs1295977948 CA392726130	458	G>D		No	ClinGen TOPMed
CA7601495 rs756017281	461	A>T		No	ClinGen ExAC gnomAD
CA392726155 rs1375553290	462	M>V		No	ClinGen TOPMed
rs1314145412 CA392726168	463	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA392726180 rs1416066398	465	G>C		No	ClinGen gnomAD
CA392726181 rs753340432	465	G>D		No	ClinGen ExAC gnomAD
CA7601497 rs753340432	465	G>V		No	ClinGen ExAC gnomAD
CA7601498 rs756859717	466	V>L		No	ClinGen ExAC gnomAD
rs1465023956 CA392726189	467	V>M		No	ClinGen TOPMed
VAR_018299 rs2729835 CA7601499	469	R>K	does not affect serine protease activity; shows reduced tumor suppressor activity; shows reduced ability to down-regulate phosphatidylethanolamine (PtdEtn) levels [UniProt]	No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA392726204 rs2729835	469	R>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2729835 CA392726205	469	R>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1171636891 CA392726215	470	K>N		No	ClinGen TOPMed
rs1363318456 CA392726212	470	K>R		No	ClinGen gnomAD
CA7601501 rs746733829	472	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1217965488 CA392726232	473	Y>F		No	ClinGen gnomAD
rs1278619260 CA392726238	474	G>R		No	ClinGen gnomAD
CA392726237 rs1278619260	474	G>S		No	ClinGen gnomAD
rs1441269797 CA392726242	474	G>V		No	ClinGen gnomAD
CA7601503 rs556545187	475	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1463291764 CA392726253	476	C>F		No	ClinGen gnomAD
CA392726249 rs1259751471	476	C>R		No	ClinGen TOPMed
CA7601506 rs773611217	479	Q>R		No	ClinGen ExAC gnomAD
rs148995972 CA7601509	480	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7601508 rs771050457	480	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs565191477 CA272056609	483	A>T		No	ClinGen TOPMed gnomAD
CA392726301 rs1276022933	483	A>V		No	ClinGen TOPMed
CA7601512 rs767735522	484	S>P		No	ClinGen ExAC gnomAD
rs1213945081 CA392726325	487	G>A		No	ClinGen gnomAD
TCGA novel	488	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7601513 rs200480788	489	A>T		No	ClinGen ExAC gnomAD
CA7601515 rs764053537	491	G>D		No	ClinGen ExAC TOPMed gnomAD
CA7601514 rs367940459	491	G>R		No	ClinGen ESP ExAC gnomAD
rs756804133 CA7601517	492	A>D		No	ClinGen ExAC gnomAD
rs753760490 CA392726349	492	A>S		No	ClinGen ExAC TOPMed gnomAD
CA7601516 rs753760490	492	A>T		No	ClinGen ExAC TOPMed gnomAD
CA392726355 rs1330450786	493	S>N		No	ClinGen gnomAD
rs369446060 CA7601520	493	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	496	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326516034 CA392726441 COSM257261	502	E>*	large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1207694084 CA392726449	502	E>D		No	ClinGen TOPMed gnomAD
rs1290225341 CA392726452	503	L>M		No	ClinGen gnomAD
CA392726468 rs1463939302	504	D>G		No	ClinGen TOPMed
rs372475477 CA7601524	504	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA7601527 rs770997369	506	E>D		No	ClinGen ExAC gnomAD
rs778310160 CA7601526	506	E>K		No	ClinGen ExAC gnomAD
CA7601525 rs778310160	506	E>Q		No	ClinGen ExAC gnomAD
CA7601528 rs377555615	507	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs377555615 CA392726496	507	T>P		No	ClinGen 1000Genomes ExAC gnomAD
CA392726512 rs1566994689	508	I>T		No	ClinGen Ensembl
CA392726506 rs1184322607	508	I>V		No	ClinGen gnomAD
CA392726554 rs1163985910	511	K>N		No	ClinGen gnomAD
CA392726548 rs1456842586	511	K>T		No	ClinGen gnomAD
CA272056674 rs1040866866	512	V>I		No	ClinGen TOPMed gnomAD
rs1040866866 CA392726557	512	V>L		No	ClinGen TOPMed gnomAD
rs1566994705 CA392726569	513	P>S		No	ClinGen Ensembl
rs1566994708	514	P>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA7601532 rs760488771	514	P>Q		No	ClinGen ExAC gnomAD
rs775607481 CA7601531	514	P>T		No	ClinGen ExAC gnomAD
CA392726623 rs1185596927	519	V>I		No	ClinGen TOPMed
CA392726626 rs1185596927	519	V>L		No	ClinGen TOPMed
rs1287065271 CA392726656	522	I>V		No	ClinGen TOPMed gnomAD
rs761908040 CA7601535	526	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs1358070384 CA392726720	527	S>F		No	ClinGen gnomAD
rs749890606 CA7601538	530	L>F		No	ClinGen ExAC gnomAD
rs1483294303 CA392726796	532	S>C		No	ClinGen gnomAD
rs1483294303 CA392726799	532	S>G		No	ClinGen gnomAD
CA272056776 rs991619952	535	L>V		No	ClinGen TOPMed
rs199868189 CA272056782	543	K>T		No	ClinGen Ensembl
rs1370376699 CA392727059	545	R>I		No	ClinGen gnomAD
CA392727067 rs1471914250	545	R>S		No	ClinGen gnomAD
CA392727081 rs1242081508	546	S>*		No	ClinGen TOPMed
CA7601541 rs766012269	547	D>G		No	ClinGen ExAC gnomAD
CA272056794 rs1024403619	547	D>N		No	ClinGen TOPMed

No associated diseases with P83111

2 regional properties for P83111

Type	Name	Position	InterPro Accession
domain	Beta-lactamase-related	116 - 233	IPR001466-1
domain	Beta-lactamase-related	302 - 524	IPR001466-2

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
peptidase activity	Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

3 GO annotations of biological process

Name	Definition
lipid metabolic process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of lipid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9EP89	Lactb	Serine beta-lactamase-like protein LACTB, mitochondrial	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MYRLMSAVTA	RAAAPGGLAS	SCGRRGVHQR	AGLPPLGHGW	VGGLGLGLGL	ALGVKLAGGL
70	80	90	100	110	120
RGAAPAQSPA	APDPEASPLA	EPPQEQSLAP	WSPQTPAPPC	SRCFARAIES	SRDLLHRIKD
130	140	150	160	170	180
EVGAPGIVVG	VSVDGKEVWS	EGLGYADVEN	RVPCKPETVM	RIASISKSLT	MVALAKLWEA
190	200	210	220	230	240
GKLDLDIPVQ	HYVPEFPEKE	YEGEKVSVTT	RLLISHLSGI	RHYEKDIKKV	KEEKAYKALK
250	260	270	280	290	300
MMKENVAFEQ	EKEGKSNEKN	DFTKFKTEQE	NEAKCRNSKP	GKKKNDFEQG	ELYLREKFEN
310	320	330	340	350	360
SIESLRLFKN	DPLFFKPGSQ	FLYSTFGYTL	LAAIVERASG	CKYLDYMQKI	FHDLDMLTTV
370	380	390	400	410	420
QEENEPVIYN	RARFYVYNKK	KRLVNTPYVD	NSYKWAGGGF	LSTVGDLLKF	GNAMLYGYQV
430	440	450	460	470	480
GLFKNSNENL	LPGYLKPETM	VMMWTPVPNT	EMSWDKEGKY	AMAWGVVERK	QTYGSCRKQR
490	500	510	520	530	540
HYASHTGGAV	GASSVLLVLP	EELDTETINN	KVPPRGIIVS	IICNMQSVGL	NSTALKIALE

FDKDRSD