AiPD: Autoinhibited Protein Database

P82933

Gene name	MRPS9 (RPMS9)
Protein name	28S ribosomal protein S9, mitochondrial
Names	MRP-S9, S9mt, Mitochondrial small ribosomal subunit protein uS9m
Species	Homo sapiens (Human)
KEGG Pathway	hsa:64965
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-100 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

30-100 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

43 structures for P82933

Entry ID	Method	Resolution	Chain	Position	Source
3J9M	EM	350 A	AG	1-396	PDB
6NU2	EM	390 A	AG	71-396	PDB
6NU3	EM	440 A	AG	1-396	PDB
6RW4	EM	297 A	G	1-396	PDB
6RW5	EM	314 A	G	1-396	PDB
6VLZ	EM	297 A	AG	1-396	PDB
6VMI	EM	296 A	AG	1-396	PDB
6ZM5	EM	289 A	AG	1-396	PDB
6ZM6	EM	259 A	AG	1-396	PDB
6ZS9	EM	400 A	AG	1-396	PDB
6ZSA	EM	400 A	AG	1-396	PDB
6ZSB	EM	450 A	AG	1-396	PDB
6ZSC	EM	350 A	AG	1-396	PDB
6ZSD	EM	370 A	AG	1-396	PDB
6ZSE	EM	500 A	AG	1-396	PDB
6ZSG	EM	400 A	AG	1-396	PDB
7A5F	EM	440 A	G6	1-396	PDB
7A5G	EM	433 A	G6	1-396	PDB
7A5I	EM	370 A	G6	1-396	PDB
7A5K	EM	370 A	G6	1-396	PDB
7L08	EM	349 A	AG	1-396	PDB
7OG4	EM	380 A	AG	1-396	PDB
7P2E	EM	240 A	G	1-396	PDB
7PNX	EM	276 A	G	1-396	PDB
7PNY	EM	306 A	G	1-396	PDB
7PNZ	EM	309 A	G	1-396	PDB
7PO0	EM	290 A	G	1-396	PDB
7PO1	EM	292 A	G	1-396	PDB
7PO2	EM	309 A	G	1-396	PDB
7PO3	EM	292 A	G	1-396	PDB
7QI4	EM	221 A	AG	1-396	PDB
7QI5	EM	263 A	AG	1-396	PDB
7QI6	EM	298 A	AG	1-396	PDB
8ANY	EM	285 A	AG	1-396	PDB
8CSP	EM	266 A	G	1-396	PDB
8CSQ	EM	254 A	G	1-396	PDB
8CSR	EM	254 A	G	1-396	PDB
8CSS	EM	236 A	G	1-396	PDB
8CST	EM	285 A	G	1-396	PDB
8CSU	EM	303 A	G	1-396	PDB
8OIR	EM	310 A	Ag	1-396	PDB
8OIS	EM	300 A	Ag	1-396	PDB
AF-P82933-F1	Predicted				AlphaFoldDB

328 variants for P82933

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA1813092 rs149402894	2	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA347978537 rs1424699048	3	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	4	P>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780546114 CA1813096	4	P>L		No	ClinGen ExAC gnomAD
rs1293585903 CA347978559	5	C>F		No	ClinGen gnomAD
CA1813097 rs749793138	5	C>R		No	ClinGen ExAC gnomAD
rs968669025 CA53325694	6	V>L		No	ClinGen gnomAD
CA347978572 rs968669025	6	V>M		No	ClinGen gnomAD
rs755309848 CA1813098	8	Y>N		No	ClinGen ExAC gnomAD
CA1813099 rs779286962	9	G>S		No	ClinGen ExAC gnomAD
rs1213759527 CA347978698	11	A>G		No	ClinGen gnomAD
CA1813101 rs772334305	12	V>A		No	ClinGen ExAC gnomAD
VAR_047902 CA1813102 rs13399067	13	S>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1573409929 CA347978750	14	Y>S		No	ClinGen Ensembl
CA1813103 rs747044047	15	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1489880983 CA347978810	16	L>R		No	ClinGen gnomAD
rs765094516 CA1813107	17	L>F		No	ClinGen ExAC gnomAD
CA347978823 rs765094516	17	L>V		No	ClinGen ExAC gnomAD
rs769245532 CA1813109	18	L>F		No	ClinGen ExAC gnomAD
rs200027821 CA1813110	19	W>*		No	ClinGen ExAC TOPMed gnomAD
CA1813111 rs201725510	20	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA347978918 rs1312396530	20	G>R		No	ClinGen TOPMed
rs201725510 CA1813112	20	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1813113 rs766982777	22	G>A		No	ClinGen ExAC gnomAD
rs76640438 CA1813114	23	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA53325862 rs1026271014	23	S>I		No	ClinGen TOPMed gnomAD
rs1026271014 CA347979041	23	S>T		No	ClinGen TOPMed gnomAD
rs1422229689 CA347979081	25	A>S		No	ClinGen TOPMed gnomAD
rs1422229689 CA347979074	25	A>T		No	ClinGen TOPMed gnomAD
CA347979095 rs1299562807	26	R>W		No	ClinGen gnomAD
CA53325916 rs945331207	28	Q>E		No	ClinGen TOPMed
rs376226529 CA1813116	29	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA1813117 rs753001424	30	L>F		No	ClinGen ExAC gnomAD
CA53325924 rs927984392	31	W>*		No	ClinGen TOPMed
CA1813118 rs758766997	32	K>R		No	ClinGen ExAC gnomAD
CA1813119 rs778013991	33	T>I		No	ClinGen ExAC TOPMed gnomAD
CA347979293 rs1357628430	34	A>V		No	ClinGen gnomAD
CA1813121 rs576049076	36	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs747216572 CA1813120	36	P>S		No	ClinGen ExAC gnomAD
CA1813122 rs781171527	37	E>K		No	ClinGen ExAC gnomAD
rs201247349 CA1813123	39	Q>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1813124 rs200448846	41	N>D		No	ClinGen 1000Genomes ExAC gnomAD
rs762774357 CA1813126	44	S>F		No	ClinGen ExAC gnomAD
rs780895573 CA53317147	48	R>K		No	ClinGen Ensembl
rs1449231896 CA347978116	54	F>Y		No	ClinGen gnomAD
rs780103515 CA347978158	57	P>A		No	ClinGen ExAC gnomAD
rs749263482 CA1813144	57	P>Q		No	ClinGen ExAC
rs780103515 CA347978159	57	P>S		No	ClinGen ExAC gnomAD
rs780103515 CA1813143	57	P>T		No	ClinGen ExAC gnomAD
CA1813146 rs774078996	61	V>F		No	ClinGen ExAC TOPMed gnomAD
rs774078996 COSM1239475 CA53317192	61	V>I	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs774078996 CA347978241	61	V>L		No	ClinGen ExAC TOPMed gnomAD
rs761508821 CA1813147	66	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1813148 rs771563820	66	R>H		No	ClinGen ExAC TOPMed gnomAD
CA347978325 rs771563820	66	R>L		No	ClinGen ExAC TOPMed gnomAD
rs771563820 CA347978323	66	R>P		No	ClinGen ExAC TOPMed gnomAD
CA1813149 rs772854484	67	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1320450358 CA347978353	68	T>S		No	ClinGen gnomAD
rs760138405 CA1813150	69	Y>*		No	ClinGen ExAC
CA1813151 rs765894921	70	T>A		No	ClinGen ExAC gnomAD
CA347978436 rs1224113569	72	D>E		No	ClinGen TOPMed
rs368177472 CA1813152	72	D>H		No	ClinGen ESP ExAC gnomAD
rs368177472 CA347978425	72	D>N		No	ClinGen ESP ExAC gnomAD
rs763411120 COSM1738811 CA1813153	73	F>L	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA347978544 rs1573417735	82	N>D		No	ClinGen Ensembl
CA1813155 rs148856687	82	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA1813156 rs757655077 CA347978560	83	I>L		No	ClinGen ExAC TOPMed gnomAD
CA1813157 rs139442155	83	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757655077 CA53317246	83	I>V		No	ClinGen ExAC TOPMed gnomAD
CA53317297 rs888082808	85	K>N		No	ClinGen TOPMed
rs942371433 CA53317318	86	R>K		No	ClinGen Ensembl
CA1813158 rs750709986	87	H>R		No	ClinGen ExAC gnomAD
CA347978738 rs1171199684	90	N>K		No	ClinGen TOPMed gnomAD
rs1318504762 CA347978726	90	N>Y		No	ClinGen TOPMed
CA347978752 rs1410574458	91	M>V		No	ClinGen TOPMed
CA347978822 rs1325584937	92	M>I		No	ClinGen gnomAD
rs780334135 CA1813160	92	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1331784174 CA347978845	94	E>K		No	ClinGen gnomAD
rs1404805364 CA347978894	96	P>L		No	ClinGen gnomAD
rs754926028 CA1813162	97	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs778919385 CA1813163	99	F>S		No	ClinGen ExAC gnomAD
rs1418712094 CA347979002	100	T>I		No	ClinGen TOPMed
CA347979018 rs1251145037	101	Q>R		No	ClinGen gnomAD
TCGA novel	103	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs536369726 CA1813164	103	D>V		No	ClinGen ExAC gnomAD
rs1338314667 CA347979063	103	D>Y		No	ClinGen gnomAD
rs577704289 CA1813165	104	I>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs577704289 CA1813166	104	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1444276911 CA347980972	106	R>K		No	ClinGen gnomAD
TCGA novel	106	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1011761196 CA53335102	107	A>T		No	ClinGen TOPMed gnomAD
rs1183069439 CA347980987	108	I>S		No	ClinGen TOPMed
CA347980982 rs1558757287	108	I>V		No	ClinGen Ensembl
rs1328968712 CA347981005	111	L>F		No	ClinGen gnomAD
rs1454721723 CA347981016	112	F>L		No	ClinGen gnomAD
CA1813188 rs776360588	113	P>L		No	ClinGen ExAC gnomAD
rs147264055 COSM714907 CA1813189	114	S>N	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs769380702 CA1813190	114	S>R		No	ClinGen ExAC TOPMed gnomAD
CA1813191 rs774676822	116	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1383030957 CA347981049	118	E>Q		No	ClinGen gnomAD
rs762436038 CA1813192	119	K>N		No	ClinGen ExAC gnomAD
CA1813193 rs77533759	120	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs374087859 CA53335205	120	R>Q		No	ClinGen ESP TOPMed gnomAD
rs945171081 CA53335207	121	A>T		No	ClinGen Ensembl
CA347981084 rs1239608787	124	V>L		No	ClinGen gnomAD
CA347981090 rs1260059889	125	M>L		No	ClinGen TOPMed gnomAD
CA347981091 rs1260059889	125	M>V		No	ClinGen TOPMed gnomAD
CA347981122 rs1235353933	127	H>P		No	ClinGen gnomAD
CA1813204 rs757052118	128	P>A		No	ClinGen ExAC gnomAD
CA347981149 rs1416105664	131	I>V		No	ClinGen TOPMed
CA347981172 rs1201947634	134	R>T		No	ClinGen gnomAD
CA347981178 rs1240252082	135	Q>*		No	ClinGen gnomAD
TCGA novel	136	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780669976 CA1813206	137	A>P		No	ClinGen ExAC TOPMed gnomAD
CA1813205 rs780669976	137	A>T		No	ClinGen ExAC TOPMed gnomAD
rs998994032 CA53341908	137	A>V		No	ClinGen TOPMed
CA347982034 rs1573440524	140	W>C		No	ClinGen Ensembl
rs755866600 CA1813228	141	G>E		No	ClinGen ExAC gnomAD
TCGA novel	143	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1489509513 CA347982066	143	D>V		No	ClinGen gnomAD
rs1378819811 CA347982074	144	G>D		No	ClinGen TOPMed
rs771451045 CA1813229	144	G>S		No	ClinGen ExAC TOPMed gnomAD
CA1813230 rs570793446	145	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs371019550 CA1813231 COSM1004740	145	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA347982103 rs1335570503	147	F>L		No	ClinGen TOPMed
CA1813232 rs778372187	148	H>Q		No	ClinGen ExAC gnomAD
COSM356089 rs201445337 CA1813234	149	Y>C	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA1813233 rs202077550	149	Y>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs202077550 CA53341953	149	Y>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs201445337 CA347982132	149	Y>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1163256763 CA347982141	150	L>F		No	ClinGen TOPMed gnomAD
rs200314985 CA53341978	151	F>L		No	ClinGen 1000Genomes
CA347982171 rs1352200087	152	Y>C		No	ClinGen gnomAD
rs1558759831 CA347982169	152	Y>H		No	ClinGen Ensembl
CA347982172 rs1352200087	152	Y>S		No	ClinGen gnomAD
CA347982191 rs1420905657	154	G>S		No	ClinGen TOPMed
rs188400447 CA1813236	154	G>V		No	ClinGen 1000Genomes ExAC
rs770000981 CA1813237	155	K>R		No	ClinGen ExAC gnomAD
CA53342009 rs1021995746	156	Q>*		No	ClinGen Ensembl
rs1271667159 CA347982239	158	Y>C		No	ClinGen gnomAD
rs1403083477 CA347982233	158	Y>H		No	ClinGen gnomAD
rs764645292 CA53342022	159	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs775694419 CA1813238	162	M>I		No	ClinGen ExAC TOPMed gnomAD
CA1813239 rs762981922	163	H>R		No	ClinGen ExAC TOPMed gnomAD
CA347984014 rs1183856267	164	D>A		No	ClinGen gnomAD
CA53349087 rs368606260	166	Y>C		No	ClinGen ESP TOPMed gnomAD
CA347984034 rs1241914685	166	Y>H		No	ClinGen gnomAD
TCGA novel	166	Y>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1009093279 CA53349116	168	M>I		No	ClinGen Ensembl
rs749564760 CA1813258	168	M>T		No	ClinGen ExAC gnomAD
CA1813259 rs372692502	170	L>P		No	ClinGen ESP ExAC gnomAD
CA1813260 rs774485716	176	Q>*		No	ClinGen ExAC gnomAD
rs1156608177 CA347984120	176	Q>P		No	ClinGen gnomAD
CA347984128 rs1408066961	177	S>N		No	ClinGen gnomAD
TCGA novel	178	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347984149 rs1558762497	180	Q>E		No	ClinGen Ensembl
CA1813261 rs1553443691	184	L>R		No	ClinGen Ensembl
rs1020027160 CA53349124	184	L>V		No	ClinGen Ensembl
rs773050510 CA1813265	187	E>G		No	ClinGen ExAC gnomAD
rs1356455531	189	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1813289 rs770843495	193	D>E		No	ClinGen ExAC TOPMed gnomAD
CA1813287 rs371663054	193	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs759417452 CA1813290	194	V>M		No	ClinGen ExAC TOPMed gnomAD
CA347984266 rs1168723495	196	G>D		No	ClinGen gnomAD
CA347984275 rs1374887897	197	S>R		No	ClinGen TOPMed
rs1408265271 CA347984296	200	L>P		No	ClinGen gnomAD
CA347984298 rs1305109985	201	I>L		No	ClinGen gnomAD
CA53349957 rs954369082	202	K>E		No	ClinGen Ensembl
rs762478746 CA1813293	203	E>K		No	ClinGen ExAC gnomAD
rs1558762742 CA347984325	204	E>D		No	ClinGen Ensembl
rs763562427 CA1813294	204	E>V		No	ClinGen ExAC gnomAD
CA1813295 rs528306990	206	E>G		No	ClinGen 1000Genomes ExAC gnomAD
rs756649515 CA1813296	207	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA347984351 rs1215267922	208	M>I		No	ClinGen TOPMed
CA347984365 rs1318172825	210	V>G		No	ClinGen TOPMed gnomAD
rs780387128 CA1813297	210	V>L		No	ClinGen ExAC TOPMed gnomAD
rs183986236 CA1813298	211	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1813299 rs755362859	215	D>H		No	ClinGen ExAC gnomAD
rs1558762769 CA347984407	217	D>A		No	ClinGen Ensembl
rs1181730849 CA347984428	218	Y>C		No	ClinGen gnomAD
rs1420165024 CA347984424	218	Y>N		No	ClinGen gnomAD
rs1000185133 CA53351937	219	M>T		No	ClinGen TOPMed
rs1306379695 CA347984447	220	Q>H		No	ClinGen TOPMed
CA347984443 rs1410148760	220	Q>P		No	ClinGen gnomAD
CA1813322 rs757444980	222	I>V		No	ClinGen ExAC gnomAD
CA1813323 rs770559952	223	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA347984463 COSM200359 rs1177688244	223	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1300518951 CA347984480	226	E>G		No	ClinGen gnomAD
rs745850731 CA1813324	227	K>E		No	ClinGen ExAC gnomAD
TCGA novel	229	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769682640 CA1813325	230	T>S		No	ClinGen ExAC gnomAD
CA347984513 rs1348624580	231	S>*		No	ClinGen gnomAD
CA1813329 rs774062277	232	Q>R		No	ClinGen ExAC gnomAD
rs201319316 CA1813331	233	C>F		No	ClinGen ExAC
rs149588889 CA1813333	234	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1004741 rs149588889 CA1813334	234	G>D	endometrium Variant assessed as Somatic; 4.625e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA347984534 rs976548455	235	A>P		No	ClinGen gnomAD
CA53352069 rs976548455	235	A>T		No	ClinGen gnomAD
rs752945200 CA1813335	236	A>P		No	ClinGen ExAC TOPMed gnomAD
CA347984540 rs752945200	236	A>S		No	ClinGen ExAC TOPMed gnomAD
CA347984576 rs1200577975	241	V>L		No	ClinGen TOPMed gnomAD
rs1200577975 CA347984578	241	V>M		No	ClinGen TOPMed gnomAD
CA1813339 rs757391749	242	Q>H		No	ClinGen ExAC gnomAD
CA347984590 rs1173530477	243	R>G		No	ClinGen gnomAD
CA347984591 rs1473300121	243	R>K		No	ClinGen TOPMed
CA1813340 rs781462761	243	R>S		No	ClinGen ExAC gnomAD
rs745797611 CA1813341	245	R>*	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1813342 rs116793449	245	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1813344 rs748972416	247	S>N		No	ClinGen ExAC gnomAD
CA347985215 rs1558763551	248	V>I		No	ClinGen Ensembl
rs773848451 CA1813346	249	T>I		No	ClinGen ExAC gnomAD
CA1813347 rs747834778	251	E>D		No	ClinGen ExAC gnomAD
rs369387444 CA1813349	253	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1297979087	254	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs969397120 CA347985304	255	Q>E		No	ClinGen gnomAD
rs969397120 CA53352208	255	Q>K		No	ClinGen gnomAD
CA347985317 rs1490970728	256	L>V		No	ClinGen gnomAD
CA347985340 rs1348726303	257	I>M		No	ClinGen TOPMed
rs373106870 CA1813350	261	Q>R		No	ClinGen ESP ExAC TOPMed
CA1813351 COSM1004742 rs765595224	262	Y>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs763179385 CA1813353	264	E>A		No	ClinGen ExAC gnomAD
CA1813352 rs147161518	264	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764569523 CA1813354	265	Q>*		No	ClinGen ExAC gnomAD
rs751802531 CA1813355	267	M>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	268	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1167362716 CA347985479	268	A>V		No	ClinGen gnomAD
CA1813357 rs573733170	271	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs377378245 CA1813356	271	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA347985535 rs6543282 CA347985533	272	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1813359 rs202009661	273	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1283722392 CA347985620	274	G>D		No	ClinGen gnomAD
rs373863935 CA1813379	276	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs753711321 CA1813380	278	T>P		No	ClinGen ExAC gnomAD
CA1813381 rs754998401	280	K>E		No	ClinGen ExAC
CA347985707 rs1207293337	281	A>V		No	ClinGen TOPMed gnomAD
CA347985728 rs1301992020	283	A>T		No	ClinGen TOPMed
rs1265846177 CA347985759	286	Y>H		No	ClinGen gnomAD
rs544151641 CA1813384	290	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	292	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1371026276 CA347985842	293	I>V		No	ClinGen TOPMed
rs1408699469 CA347985875	295	V>A		No	ClinGen gnomAD
CA347985885 rs1456501300	296	N>S		No	ClinGen gnomAD
CA53353201 rs370548113	299	D>E		No	ClinGen ESP TOPMed gnomAD
rs200796955 CA1813386	299	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA347985925 rs1386392276	300	Y>C		No	ClinGen gnomAD
CA1813387 rs777356053	301	Q>E		No	ClinGen ExAC gnomAD
rs1333543444 CA347985936	302	L>V		No	ClinGen gnomAD
CA1813388 rs746724738	304	F>L		No	ClinGen ExAC TOPMed gnomAD
rs770317141 CA1813389	305	P>L		No	ClinGen ExAC TOPMed gnomAD
rs950145208 CA53353250	306	I>F		No	ClinGen TOPMed
CA1813393 rs775008866	307	T>R		No	ClinGen ExAC TOPMed gnomAD
CA1813392 rs769216183	307	T>S		No	ClinGen ExAC TOPMed gnomAD
CA347985972 rs1250483001	308	Q>K		No	ClinGen TOPMed
rs762216707 CA1813394	309	D>G		No	ClinGen ExAC TOPMed gnomAD
CA347986152 rs1202941662	312	Q>H		No	ClinGen gnomAD
rs953029639 CA53355921 COSM1669187	314	M>V	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated Ensembl
rs773697249 CA1813414	320	V>D		No	ClinGen ExAC gnomAD
TCGA novel	320	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA347986257 rs1376102668	321	D>N		No	ClinGen gnomAD
rs771129322 CA1813416	322	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs747341338 CA1813415	322	R>W		No	ClinGen ExAC TOPMed gnomAD
rs765341948 CA1813419	324	G>E		No	ClinGen ExAC gnomAD
CA347986291 rs1291961731	324	G>R		No	ClinGen gnomAD
CA1813422 rs762934939	326	H>Y		No	ClinGen ExAC gnomAD
rs763870949 CA1813423	327	D>N		No	ClinGen ExAC TOPMed gnomAD
CA1813424 rs751300198	327	D>V		No	ClinGen ExAC gnomAD
rs767145979 CA347986341 CA53356072	328	V>L		No	ClinGen ExAC TOPMed gnomAD
CA1813426 rs767145979	328	V>M		No	ClinGen ExAC TOPMed gnomAD
CA347986383 rs1293854501	331	T>P		No	ClinGen gnomAD
rs750071273 CA1813427	331	T>R		No	ClinGen ExAC gnomAD
rs1558765103 CA347986444	334	G>A		No	ClinGen Ensembl
rs1573452271 CA347986432	334	G>R		No	ClinGen Ensembl
TCGA novel	335	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1813430 rs145751106	336	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779773574 CA1813431	336	G>V		No	ClinGen ExAC gnomAD
rs1573452298 CA347986480	337	R>G		No	ClinGen Ensembl
CA347986503 rs1369527978	338	S>*		No	ClinGen gnomAD
rs1573452302 CA347986501	338	S>A		No	ClinGen Ensembl
CA347986507 rs1369527978	338	S>L		No	ClinGen gnomAD
CA347986524 rs1340595471	339	A>P		No	ClinGen TOPMed
rs778158656 CA1813434	339	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA347986562 rs1383170187	341	A>G		No	ClinGen TOPMed
rs1458434894 CA347986556	341	A>T		No	ClinGen gnomAD
CA1813436 rs771232891	342	G>R		No	ClinGen ExAC gnomAD
CA1813437 rs776883347	344	I>V		No	ClinGen ExAC gnomAD
rs916589604 CA53356134	345	R>*		No	ClinGen TOPMed gnomAD
rs368226804 CA1813438	345	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA347986634 rs1263391266	347	A>T		No	ClinGen gnomAD
rs573319916 CA1813439	347	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1382429127 CA347986663	348	M>I		No	ClinGen TOPMed
CA1813440 rs372027073	349	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA347986697 rs1267742214	351	A>V		No	ClinGen gnomAD
CA1813442 rs768579252	354	S>G		No	ClinGen ExAC gnomAD
rs774175403 CA1813443	357	T>I		No	ClinGen ExAC gnomAD
CA347986830 rs1473119693	358	E>D		No	ClinGen gnomAD
CA347986827 rs1366115448	358	E>G		No	ClinGen gnomAD
rs375392443 CA1813445	358	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA1813448 rs766138553	360	E>A		No	ClinGen ExAC TOPMed gnomAD
CA1813447 COSM440929 rs371609310	360	E>K	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs371609310 CA347986863	360	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	362	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs150040776 CA1813450	362	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA347986917 rs778304398	363	W>*		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	363	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778304398 CA1813451	363	W>L		No	ClinGen ExAC TOPMed gnomAD
rs1221353907 CA347986937	364	M>V		No	ClinGen TOPMed
CA1813452 rs369132061	366	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs201203719 CA1813453	366	Q>R		No	ClinGen 1000Genomes ExAC
rs1285453116 CA347986983	367	A>P		No	ClinGen TOPMed
rs1348410949 CA347987238	368	G>V		No	ClinGen gnomAD
rs1302239982 CA347987248	369	L>P		No	ClinGen gnomAD
TCGA novel	370	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757771120 CA1813470	371	T>I		No	ClinGen ExAC gnomAD
rs757771120 CA347987272	371	T>N		No	ClinGen ExAC gnomAD
CA1813471 rs781724583	372	T>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs750727078 CA1813472	375	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA53358059 rs1022301070	375	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1205082659 CA347987325	376	V>L		No	ClinGen gnomAD
CA1813473 rs756491170	379	R>W		No	ClinGen ExAC gnomAD
rs749548860 CA1813475	388	R>C		No	ClinGen ExAC gnomAD
CA1813476 rs768755208 COSM1004743	388	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA1813477 rs368179371	389	R>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1813478 rs748268228	391	F>L		No	ClinGen ExAC TOPMed gnomAD
CA347987631 rs1167868222	392	T>A		No	ClinGen gnomAD
CA1813479 rs201628879	392	T>M		No	ClinGen ExAC TOPMed gnomAD
rs887569346 CA53358107	394	K>T		No	ClinGen TOPMed
CA1813482 rs770892498	395	K>R		No	ClinGen ExAC gnomAD
TCGA novel	396	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P82933

1 regional properties for P82933

Type	Name	Position	InterPro Accession
conserved_site	Ribosomal protein S9, conserved site	334 - 352	IPR020574

Functions

		Description
EC Number
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial small ribosomal subunit	The smaller of the two subunits of a mitochondrial ribosome.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
small ribosomal subunit	The smaller of the two subunits of a ribosome.

2 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name	Definition
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q58DQ5	MRPS9	28S ribosomal protein S9, mitochondrial	Bos taurus (Bovine)	PR

10	20	30	40	50	60
MAAPCVSYGG	AVSYRLLLWG	RGSLARKQGL	WKTAAPELQT	NVRSQILRLR	HTAFVIPKKN
70	80	90	100	110	120
VPTSKRETYT	EDFIKKQIEE	FNIGKRHLAN	MMGEDPETFT	QEDIDRAIAY	LFPSGLFEKR
130	140	150	160	170	180
ARPVMKHPEQ	IFPRQRAIQW	GEDGRPFHYL	FYTGKQSYYS	LMHDVYGMLL	NLEKHQSHLQ
190	200	210	220	230	240
AKSLLPEKTV	TRDVIGSRWL	IKEELEEMLV	EKLSDLDYMQ	FIRLLEKLLT	SQCGAAEEEF
250	260	270	280	290	300
VQRFRRSVTL	ESKKQLIEPV	QYDEQGMAFS	KSEGKRKTAK	AEAIVYKHGS	GRIKVNGIDY
310	320	330	340	350	360
QLYFPITQDR	EQLMFPFHFV	DRLGKHDVTC	TVSGGGRSAQ	AGAIRLAMAK	ALCSFVTEDE
370	380	390
VEWMRQAGLL	TTDPRVRERK	KPGQEGARRK	FTWKKR