Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

41 structures for P82912

Entry ID Method Resolution Chain Position Source
3J9M EM 350 A AI 1-194 PDB
6NU2 EM 390 A AI 59-194 PDB
6NU3 EM 440 A AI 1-194 PDB
6RW4 EM 297 A I 1-194 PDB
6RW5 EM 314 A I 1-194 PDB
6VLZ EM 297 A AI 1-194 PDB
6VMI EM 296 A AI 1-194 PDB
6ZM5 EM 289 A AI 1-194 PDB
6ZM6 EM 259 A AI 1-194 PDB
6ZS9 EM 400 A AI 1-194 PDB
6ZSA EM 400 A AI 1-194 PDB
6ZSB EM 450 A AI 1-194 PDB
6ZSC EM 350 A AI 1-194 PDB
6ZSD EM 370 A AI 1-194 PDB
6ZSE EM 500 A AI 1-194 PDB
6ZSG EM 400 A AI 1-194 PDB
7A5F EM 440 A I6 1-194 PDB
7A5G EM 433 A I6 1-194 PDB
7A5I EM 370 A I6 1-194 PDB
7A5K EM 370 A I6 1-194 PDB
7L08 EM 349 A AI 1-194 PDB
7OG4 EM 380 A AI 1-194 PDB
7P2E EM 240 A I 1-194 PDB
7PNX EM 276 A I 1-194 PDB
7PNY EM 306 A I 1-194 PDB
7PNZ EM 309 A I 1-194 PDB
7PO0 EM 290 A I 1-194 PDB
7PO1 EM 292 A I 1-194 PDB
7PO2 EM 309 A I 1-194 PDB
7PO3 EM 292 A I 1-194 PDB
7QI4 EM 221 A AI 1-194 PDB
7QI5 EM 263 A AI 1-194 PDB
7QI6 EM 298 A AI 1-194 PDB
8ANY EM 285 A AI 1-194 PDB
8CSR EM 254 A I 1-194 PDB
8CSS EM 236 A I 1-194 PDB
8CST EM 285 A I 1-194 PDB
8CSU EM 303 A I 1-194 PDB
8OIR EM 310 A Ai 1-194 PDB
8OIS EM 300 A Ai 1-194 PDB
AF-P82912-F1 Predicted AlphaFoldDB

179 variants for P82912

Variant ID(s) Position Change Description Diseaes Association Provenance
CA393704977
rs1382971423
2 Q>E No ClinGen
gnomAD
CA7717746
rs199864572
3 A>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA393705005
rs1363073925
4 V>A No ClinGen
gnomAD
CA7717747
rs371970512
6 N>I No ClinGen
ESP
ExAC
gnomAD
CA7717748
rs763313554
7 A>P No ClinGen
ExAC
gnomAD
rs144247178
CA7717749
7 A>V No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs185895652
CA7717752
8 G>E No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs148734646
CA7717750
8 G>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs185895652
CA7717751
8 G>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA274454458
rs201980995
9 S>* No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7717753
rs201980995
9 S>L No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA274454454
rs201980995
9 S>W No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs905375225
CA274454472
10 R>L No ClinGen
TOPMed
gnomAD
rs905375225
CA274454471
10 R>Q No ClinGen
TOPMed
gnomAD
rs16941904
VAR_052054
CA7717755
10 R>W No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
CA393705078
rs1236009202
11 F>C No ClinGen
TOPMed
CA7717757
rs758094710
11 F>L No ClinGen
ExAC
TOPMed
gnomAD
rs1598286787
CA393705075
11 F>V No ClinGen
Ensembl
CA7717758
rs777109331
12 L>R No ClinGen
ExAC
gnomAD
CA393705100
rs1160450951
13 R>Q No ClinGen
TOPMed
gnomAD
rs1454535143
CA393705098
13 R>W No ClinGen
gnomAD
rs781761457
CA7717761
15 W>R No ClinGen
ExAC
gnomAD
CA393705133
rs1370801929
16 T>A No ClinGen
gnomAD
rs867329734
CA274454520
17 W>* No ClinGen
Ensembl
CA7717762
rs746417496
17 W>R No ClinGen
ExAC
rs1567041956
CA393705168
18 P>L No ClinGen
Ensembl
CA393705160
rs1320646142
18 P>T No ClinGen
TOPMed
rs1326622020
CA393705174
19 Q>* No ClinGen
TOPMed
gnomAD
rs770260993
CA7717763
20 T>A No ClinGen
ExAC
TOPMed
gnomAD
CA393705190
rs1384955838
20 T>I No ClinGen
TOPMed
gnomAD
CA393705191
rs1285644706
21 A>T No ClinGen
TOPMed
rs201087926
CA7717764
22 G>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA393705197
rs201087926
22 G>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA393705266
rs748362898
23 R>S No ClinGen
ExAC
TOPMed
gnomAD
rs772119585
CA7717788
24 V>F No ClinGen
ExAC
gnomAD
rs772119585
CA393705277
24 V>I No ClinGen
ExAC
gnomAD
CA274454680
rs892806502
26 A>D No ClinGen
gnomAD
CA393705317
rs892806502
26 A>V No ClinGen
gnomAD
rs199770606
CA274454694
27 R>G No ClinGen
ExAC
TOPMed
gnomAD
CA7717791
rs769728154
29 P>S No ClinGen
ExAC
gnomAD
rs775090003
CA7717792
30 A>T No ClinGen
ExAC
gnomAD
rs762797699
CA7717793
30 A>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs763862491
CA7717794
31 G>R No ClinGen
ExAC
TOPMed
gnomAD
rs763862491
CA393705399
31 G>W No ClinGen
ExAC
TOPMed
gnomAD
rs1341825392
CA393705411
32 T>A No ClinGen
gnomAD
rs774031538
CA7717797
35 T>R No ClinGen
ExAC
TOPMed
gnomAD
CA393705490
rs1262461691
36 G>D No ClinGen
gnomAD
rs756628463
CA7717801
37 A>G No ClinGen
ExAC
gnomAD
CA7717800
rs749957719
37 A>S No ClinGen
ExAC
gnomAD
rs754366970
COSM1740192
CA7717803
38 R>* haematopoietic_and_lymphoid_tissue [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA393705528
rs1357114480
38 R>Q No ClinGen
gnomAD
rs1409200709
CA393705538
39 Q>E No ClinGen
TOPMed
CA7717805
rs779197417
39 Q>R No ClinGen
ExAC
TOPMed
gnomAD
CA274454730
rs576217619
40 L>P No ClinGen
1000Genomes
CA7717806
rs748355847
41 Q>R No ClinGen
ExAC
gnomAD
CA393705585
rs1296107575
42 D>N No ClinGen
gnomAD
rs777764544
CA393705612
43 A>G No ClinGen
ExAC
gnomAD
rs777764544
CA7717808
43 A>V No ClinGen
ExAC
gnomAD
CA393705647
rs1281151821
45 A>G No ClinGen
gnomAD
rs372077725
CA7717809
45 A>T No ClinGen
ExAC
TOPMed
gnomAD
rs1222656354
CA393705723
50 E>Q No ClinGen
TOPMed
CA393705734
rs147602817
51 Q>* No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
VAR_052055
rs16941907
CA7717813
51 Q>H No ClinGen
UniProt
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
CA7717811
rs147602817
51 Q>K No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7717812
rs749231754
51 Q>L No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 51 Q>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1035236987
CA274454753
52 N>I No ClinGen
Ensembl
CA393705750
rs1035236987
52 N>T No ClinGen
Ensembl
rs761489372
CA7717815
54 A>D No ClinGen
ExAC
TOPMed
gnomAD
rs761489372
CA7717816
54 A>V No ClinGen
ExAC
TOPMed
gnomAD
rs1422718585
CA393705820
56 S>N No ClinGen
gnomAD
CA7717818
rs760254324
57 H>P No ClinGen
ExAC
gnomAD
CA393705868
rs1455225205
58 T>I No ClinGen
gnomAD
TCGA novel 59 K>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA393705896
rs1365178211
60 F>S No ClinGen
gnomAD
rs1405671286
CA393705891
60 F>V No ClinGen
TOPMed
CA393706977
rs1337858563
61 S>R No ClinGen
TOPMed
CA393706991
rs1473519704
63 Y>C No ClinGen
gnomAD
rs765677167
CA7717842
64 P>L No ClinGen
ExAC
TOPMed
gnomAD
CA393707009
rs1412345112
66 I>T No ClinGen
gnomAD
rs753261109
CA7717843
67 P>S Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1166452551
CA393707036
70 E>G No ClinGen
TOPMed
CA393707040
rs1567044855
71 S>G No ClinGen
Ensembl
rs1372759858
CA393707042
71 S>N No ClinGen
gnomAD
rs995631744
CA274457353
74 R>K No ClinGen
TOPMed
rs763305607
CA7717845
75 W>* No ClinGen
ExAC
gnomAD
rs1307714838
CA393707076
76 A>G No ClinGen
TOPMed
gnomAD
rs1307714838
CA393707077
76 A>V No ClinGen
TOPMed
gnomAD
COSM3741717
CA274457364
rs951473750
77 G>E liver [Cosmic] No ClinGen
cosmic curated
TOPMed
gnomAD
CA393707091
rs1282487287
79 K>* No ClinGen
gnomAD
rs751729742
CA7717848
84 P>L No ClinGen
ExAC
gnomAD
CA7717847
rs751729742
84 P>R No ClinGen
ExAC
gnomAD
CA393707137
rs1215019531
85 I>F No ClinGen
TOPMed
gnomAD
CA393707136
rs1215019531
85 I>V No ClinGen
TOPMed
gnomAD
CA393707158
rs1466664043
88 I>V No ClinGen
gnomAD
CA274457379
rs200489584
89 K>R No ClinGen
1000Genomes
CA393707184
rs1204145967
92 H>Y No ClinGen
TOPMed
gnomAD
CA7717851
rs756271529
93 N>D No ClinGen
ExAC
gnomAD
rs778708096
CA7717852
93 N>S No ClinGen
ExAC
gnomAD
rs766611176
CA7717870
97 I>T No ClinGen
ExAC
gnomAD
rs372888234
CA393707320
99 V>I No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA7717872
rs372888234
99 V>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs774759448
CA274458625
100 V>I No ClinGen
Ensembl
rs1434198643
CA393707338
101 S>P No ClinGen
gnomAD
rs1030402614
CA274458632
102 A>P No ClinGen
TOPMed
gnomAD
CA274458640
rs150288962
103 S>G No ClinGen
ESP
TOPMed
gnomAD
CA393707382
rs1230767838
105 E>K No ClinGen
gnomAD
CA7717876
rs144899922
106 P>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs769166605
CA7717878
108 A>T No ClinGen
ExAC
gnomAD
rs988867505
CA274458674
108 A>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
CA274458678
rs913217976
111 S>F No ClinGen
TOPMed
gnomAD
CA393707449
rs1268519798
112 C>Y No ClinGen
TOPMed
gnomAD
rs1293117716
CA393707460
113 G>C No ClinGen
TOPMed
rs577243785
CA7717881
114 T>I No ClinGen
1000Genomes
ExAC
gnomAD
rs1377348091
CA393707479
115 E>* No ClinGen
gnomAD
rs748353445
CA393707486
115 E>D No ClinGen
gnomAD
CA7717883
COSM197647
rs774896757
118 R>Q Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
CA7717882
COSM197646
rs149047976
118 R>W Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs544573681
CA7717884
119 N>S No ClinGen
1000Genomes
ExAC
gnomAD
CA393707566
rs1384932069
123 G>D No ClinGen
gnomAD
COSM300090
CA7717889
rs753974502
127 A>T large_intestine [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA7717890
rs758357205
127 A>V No ClinGen
ExAC
gnomAD
rs764119093
CA7717891
128 A>T No ClinGen
ExAC
gnomAD
TCGA novel 131 A>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA7717892
rs376856888
133 I>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA7717893
rs376856888
133 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs138959508
CA393707681
135 A>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs138959508
CA7717895
135 A>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs142183271
CA7717896
135 A>V No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7717897
rs779480334
136 A>V No ClinGen
ExAC
TOPMed
gnomAD
rs779356539
CA7717900
137 A>= Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
rs561515348
CA7717899
137 A>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs748561221
CA7717923
139 A>T No ClinGen
ExAC
TOPMed
gnomAD
rs1366556636
CA393708187
141 Q>* No ClinGen
TOPMed
gnomAD
rs1366556636
CA393708186
141 Q>E No ClinGen
TOPMed
gnomAD
rs772639439
CA7717924
141 Q>L No ClinGen
ExAC
gnomAD
CA7717925
rs777945324
143 G>S No ClinGen
ExAC
TOPMed
gnomAD
rs753118687
CA7717928
144 V>M No ClinGen
ExAC
TOPMed
gnomAD
rs1357311338
CA393708210
145 I>L No ClinGen
TOPMed
rs759886427
COSM966185
CA7717930
148 R>* Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] No ClinGen
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs759886427
CA7717929
148 R>G No ClinGen
ExAC
TOPMed
gnomAD
CA274459762
rs868558983
148 R>Q No ClinGen
TOPMed
gnomAD
rs775672598
CA7717931
149 V>L No ClinGen
ExAC
gnomAD
rs138464643
CA7717933
151 V>M No ClinGen
ESP
ExAC
gnomAD
CA7717934
rs142017223
158 R>C No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA7717935
rs750394239
158 R>H No ClinGen
ExAC
gnomAD
CA274460122
rs954122257
161 A>V No ClinGen
TOPMed
rs1459306984
CA393708322
162 M>V No ClinGen
gnomAD
CA393708355
rs115165544
163 H>Q No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7717954
COSM1375245
rs372417211
164 G>R large_intestine [Cosmic] No ClinGen
cosmic curated
ESP
ExAC
TOPMed
gnomAD
CA7717955
rs766119679
165 L>P No ClinGen
ExAC
gnomAD
CA393708387
rs1415529603
166 I>N No ClinGen
TOPMed
CA7717956
rs776412088
166 I>V No ClinGen
ExAC
TOPMed
gnomAD
rs1223060248
CA393708415
168 G>D No ClinGen
gnomAD
rs201886790
CA7717958
169 G>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA393708432
rs1390427136
170 L>M No ClinGen
TOPMed
CA7717960
rs757898412
171 E>* No ClinGen
ExAC
TOPMed
gnomAD
rs139694172
CA7717961
CA7717962
171 E>D No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA393708464
rs1223517257
173 I>L No ClinGen
gnomAD
rs1490093599
CA393708475
173 I>M No ClinGen
gnomAD
CA393708473
rs1244699342
173 I>S No ClinGen
gnomAD
rs149376629
CA7717963
175 I>V No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA393708537
rs1437169391
179 T>A No ClinGen
TOPMed
CA393708540
rs1437169391
179 T>P No ClinGen
TOPMed
CA274460186
rs916367056
180 P>A No ClinGen
gnomAD
CA393708551
rs916367056
180 P>S No ClinGen
gnomAD
rs746219535
CA7717965
181 I>V No ClinGen
ExAC
gnomAD
CA393708597
rs1167352801
184 N>D No ClinGen
gnomAD
rs147493631
CA274460192
184 N>S No ClinGen
ESP
TOPMed
CA7717967
rs369601980
185 G>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1598297488
CA393708630
186 C>W No ClinGen
Ensembl
rs749517118
CA7717968
187 R>C No ClinGen
ExAC
TOPMed
gnomAD
CA7717969
rs144441447
187 R>H No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs147829843
CA393708693
192 R>G No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA274460208
rs139450964
192 R>P No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7717971
rs139450964
192 R>Q No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA7717970
rs147829843
192 R>W No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs754176735
CA7717972
193 K>R No ClinGen
ExAC
gnomAD
CA393708725
rs1358528668
195 L>R No ClinGen
gnomAD

No associated diseases with P82912

1 regional properties for P82912

Type Name Position InterPro Accession
conserved_site Ribosomal S11, conserved site 162 - 184 IPR018102

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial small ribosomal subunit The smaller of the two subunits of a mitochondrial ribosome.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
mRNA 5'-UTR binding Binding to an mRNA molecule at its 5' untranslated region.
RNA binding Binding to an RNA molecule or a portion thereof.
small ribosomal subunit rRNA binding Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

4 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q95H53 rps11 30S ribosomal protein S11, chloroplastic Triticum aestivum (Wheat) PR
P62263 RPS14 40S ribosomal protein S14 Homo sapiens (Human) PR
P0C464 rps11 30S ribosomal protein S11, chloroplastic Oryza sativa subsp japonica (Rice) PR
A1E9V7 rps11 30S ribosomal protein S11, chloroplastic Sorghum bicolor (Sorghum) (Sorghum vulgare) PR
10 20 30 40 50 60
MQAVRNAGSR FLRSWTWPQT AGRVVARTPA GTICTGARQL QDAAAKQKVE QNAAPSHTKF
70 80 90 100 110 120
SIYPPIPGEE SSLRWAGKKF EEIPIAHIKA SHNNTQIQVV SASNEPLAFA SCGTEGFRNA
130 140 150 160 170 180
KKGTGIAAQT AGIAAAARAK QKGVIHIRVV VKGLGPGRLS AMHGLIMGGL EVISITDNTP
190
IPHNGCRPRK ARKL