AiPD: Autoinhibited Protein Database

P62263

Gene name	RPS14 (PRO2640)
Protein name	40S ribosomal protein S14
Names	Small ribosomal subunit protein uS11
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6208
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-151 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

101-151 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

94 structures for P62263

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	SO	1-151	PDB
4V6X	EM	500 A	AO	1-151	PDB
5A2Q	EM	390 A	O	1-151	PDB
5AJ0	EM	350 A	BO	1-151	PDB
5FLX	EM	390 A	O	1-151	PDB
5LKS	EM	360 A	SO	1-151	PDB
5OA3	EM	430 A	O	1-151	PDB
5T2C	EM	360 A	AO	1-151	PDB
5VYC	X-ray	600 A	O1/O2/O3/O4/O5/O6	1-151	PDB
6FEC	EM	630 A	j	16-151	PDB
6G18	EM	360 A	O	1-151	PDB
6G4S	EM	400 A	O	1-151	PDB
6G4W	EM	450 A	O	1-151	PDB
6G51	EM	410 A	O	1-151	PDB
6G53	EM	450 A	O	1-151	PDB
6G5H	EM	360 A	O	1-151	PDB
6G5I	EM	350 A	O	1-151	PDB
6IP5	EM	390 A	3L	1-151	PDB
6IP6	EM	450 A	3L	1-151	PDB
6IP8	EM	390 A	3L	1-151	PDB
6OLE	EM	310 A	SO	15-151	PDB
6OLF	EM	390 A	SO	15-151	PDB
6OLG	EM	340 A	BO	16-151	PDB
6OLI	EM	350 A	SO	15-151	PDB
6OLZ	EM	390 A	BO	16-151	PDB
6OM0	EM	310 A	SO	15-151	PDB
6OM7	EM	370 A	SO	15-151	PDB
6QZP	EM	290 A	SO	12-151	PDB
6XA1	EM	280 A	SO	17-151	PDB
6Y0G	EM	320 A	SO	1-151	PDB
6Y2L	EM	300 A	SO	1-151	PDB
6Y57	EM	350 A	SO	1-151	PDB
6YBD	EM	330 A	P	1-151	PDB
6YBW	EM	310 A	P	1-151	PDB
6Z6L	EM	300 A	SO	1-151	PDB
6Z6M	EM	310 A	SO	1-151	PDB
6Z6N	EM	290 A	SO	1-151	PDB
6ZLW	EM	260 A	P	1-151	PDB
6ZM7	EM	270 A	SO	1-151	PDB
6ZME	EM	300 A	SO	1-151	PDB
6ZMI	EM	260 A	SO	1-151	PDB
6ZMO	EM	310 A	SO	1-151	PDB
6ZMT	EM	300 A	P	1-151	PDB
6ZMW	EM	370 A	P	1-151	PDB
6ZN5	EM	320 A	P	17-151	PDB
6ZOJ	EM	280 A	O	1-151	PDB
6ZOK	EM	280 A	O	1-151	PDB
6ZON	EM	300 A	i	1-151	PDB
6ZP4	EM	290 A	i	1-151	PDB
6ZUO	EM	310 A	O	1-151	PDB
6ZV6	EM	290 A	O	1-151	PDB
6ZVH	EM	290 A	O	12-151	PDB
6ZXD	EM	320 A	O	1-151	PDB
6ZXE	EM	300 A	O	1-151	PDB
6ZXF	EM	370 A	O	1-151	PDB
6ZXG	EM	260 A	O	1-151	PDB
6ZXH	EM	270 A	O	1-151	PDB
7A09	EM	350 A	i	1-151	PDB
7K5I	EM	290 A	O	1-151	PDB
7MQ8	EM	360 A	NG	1-151	PDB
7MQ9	EM	387 A	NG	1-151	PDB
7MQA	EM	270 A	NG	1-151	PDB
7QP6	EM	470 A	P	1-151	PDB
7QP7	EM	370 A	P	1-151	PDB
7R4X	EM	215 A	O	1-151	PDB
7TQL	EM	340 A	P	18-151	PDB
7WTS	EM	320 A	O	1-151	PDB
7WTT	EM	310 A	O	1-151	PDB
7WTU	EM	300 A	O	1-151	PDB
7WTV	EM	350 A	O	1-151	PDB
7WTW	EM	320 A	O	1-151	PDB
7WTX	EM	310 A	O	1-151	PDB
7WTZ	EM	300 A	O	1-151	PDB
7WU0	EM	330 A	O	1-151	PDB
7XNX	EM	270 A	SO	1-151	PDB
7XNY	EM	250 A	SO	1-151	PDB
8G5Y	EM	229 A	SO	1-151	PDB
8G60	EM	254 A	SO	1-151	PDB
8G61	EM	294 A	SO	1-151	PDB
8G6J	EM	280 A	SO	1-151	PDB
8GLP	EM	167 A	SO	1-151	PDB
8IFD	EM	259 A	3L	1-151	PDB
8IFE	EM	257 A	3L	1-151	PDB
8JDJ	EM	250 A	AA	1-151	PDB
8JDK	EM	226 A	AA	1-151	PDB
8JDL	EM	242 A	AA	1-151	PDB
8JDM	EM	267 A	AA	1-151	PDB
8OZ0	EM	350 A	T	1-151	PDB
8PPK	EM	298 A	O	1-151	PDB
8PPL	EM	265 A	AO	1-151	PDB
8T4S	EM	260 A	O	1-151	PDB
8Y0W	EM	340 A	SO	1-151	PDB
8Y0X	EM	330 A	SO	1-151	PDB
AF-P62263-F1	Predicted				AlphaFoldDB

56 variants for P62263

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1161046553 CA361766324	2	A>S		No	ClinGen gnomAD
rs1270024556 CA361766259	8	E>K		No	ClinGen gnomAD
rs14926 CA129156999	10	K>E		No	ClinGen Ensembl
rs1412974229 CA361766223	10	K>R		No	ClinGen gnomAD
TCGA novel	14	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	14	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA361766156 rs1269642287	16	S>R		No	ClinGen gnomAD
rs11538773 CA129156966	23	E>*		No	ClinGen ExAC
CA3512281 rs11538773	23	E>K		No	ClinGen ExAC
rs781591371 CA3512279	28	F>L		No	ClinGen ExAC TOPMed gnomAD
rs11538771 CA129156925	29	G>C		No	ClinGen Ensembl
CA3512276 rs780510242	30	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1581277998 CA361765972	32	H>L		No	ClinGen Ensembl
TCGA novel	33	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149188074 CA129156904	38	N>S		No	ClinGen TOPMed gnomAD
CA3512274 rs750935614	42	V>A		No	ClinGen ExAC gnomAD
rs778324272 CA3512273	44	V>I		No	ClinGen ExAC gnomAD
rs756769138 CA3512272	45	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1405154598 CA361765817	47	L>I		No	ClinGen gnomAD
CA3512271 rs150548437	47	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs4841 CA129156121	50	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762926191 CA3512246	54	C>G		No	ClinGen ExAC TOPMed gnomAD
rs776911429 CA3512245	55	R>C		No	ClinGen ExAC gnomAD
CA129156054 rs11538774	73	A>P		No	ClinGen Ensembl
TCGA novel	74	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM449111 rs137915903 CA3512242	74	A>G	breast [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
rs772136334 CA3512241	77	A>S		No	ClinGen ExAC gnomAD
CA361764894 rs1452141884	80	D>N		No	ClinGen TOPMed
CA361764731 rs1391083786	89	G>R		No	ClinGen gnomAD
TCGA novel	89	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA361764719 rs1561568205	90	I>V		No	ClinGen Ensembl
CA361764686 rs1294767383	92	A>T		No	ClinGen TOPMed
CA129155993 rs769782077	92	A>V		No	ClinGen Ensembl
CA361764657 rs1385161214	94	H>Y		No	ClinGen gnomAD
rs1261795580 CA361764619	95	I>M		No	ClinGen gnomAD
rs142930327 CA3512238	95	I>V		No	ClinGen ESP ExAC TOPMed
CA361764326 rs1266203183	108	P>H		No	ClinGen gnomAD
CA3512219 rs763488998	108	P>T		No	ClinGen ExAC gnomAD
CA3512217 rs770249130	114	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1330871410 CA361764254	115	A>T		No	ClinGen gnomAD
CA3512214 rs768413585	121	R>H		No	ClinGen ExAC gnomAD
CA3512212 rs780037379	123	G>S		No	ClinGen ExAC gnomAD
CA3512211 rs758244627	124	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs779024267 CA3512209	126	I>V		No	ClinGen ExAC TOPMed gnomAD
rs377535663 CA3512207	128	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA361764062 rs1391370949	128	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1581274969 CA361763262	133	T>P		No	ClinGen Ensembl
rs754166464 CA361763240	135	I>M		No	ClinGen ExAC gnomAD
rs1464621224 CA361763245	135	I>V		No	ClinGen TOPMed
rs1282798537 CA361763203	141	R>C		No	ClinGen TOPMed
COSM3784658 CA361763202 rs1176853430	141	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated gnomAD
CA361763185 rs1449418095	143	K>N		No	ClinGen gnomAD
CA361763178 rs1226628476	145	G>S		No	ClinGen TOPMed gnomAD
rs1246687354 CA361763168	146	R>H		No	ClinGen gnomAD
CA361763163 rs1190915600	147	R>H		No	ClinGen gnomAD
CA361763152 rs1297961956	149	R>C		No	ClinGen TOPMed

No associated diseases with P62263

1 regional properties for P62263

Type	Name	Position	InterPro Accession
conserved_site	Ribosomal S11, conserved site	116 - 138	IPR018102

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic ribosome	A ribosome located in the cytosol.
cytosolic small ribosomal subunit	The small subunit of a ribosome located in the cytosol.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.

5 GO annotations of molecular function

Name	Definition
mRNA 5'-UTR binding	Binding to an mRNA molecule at its 5' untranslated region.
RNA binding	Binding to an RNA molecule or a portion thereof.
small ribosomal subunit rRNA binding	Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.
translation regulator activity	Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.

7 GO annotations of biological process

Name	Definition
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
erythrocyte differentiation	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
maturation of SSU-rRNA	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
ribosomal small subunit assembly	The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P82912	MRPS11	28S ribosomal protein S11, mitochondrial	Homo sapiens (Human)	PR

10	20	30	40	50	60
MAPRKGKEKK	EEQVISLGPQ	VAEGENVFGV	CHIFASFNDT	FVHVTDLSGK	ETICRVTGGM
70	80	90	100	110	120
KVKADRDESS	PYAAMLAAQD	VAQRCKELGI	TALHIKLRAT	GGNRTKTPGP	GAQSALRALA
130	140	150
RSGMKIGRIE	DVTPIPSDST	RRKGGRRGRR	L