AiPD: Autoinhibited Protein Database

Gene name	Renbp
Protein name	N-acylglucosamine 2-epimerase
Names	AGE, GlcNAc 2-epimerase, N-acetyl-D-glucosamine 2-epimerase, Renin-binding protein, RnBP
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:19703
EC number	5.1.3.8: Acting on carbohydrates and derivatives
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

382-430 (Predicted disordered autoinhibitory region) PR

382-430 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P82343-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389520865	69	Y>N	No	EVA
rs3389557063	71	S>N	No	EVA
rs29037794	89	E>A	No	EVA
rs3389565038	96	R>P	No	EVA
rs3389576579	101	G>D	No	EVA
rs3389576505	107	V>M	No	EVA
rs3389574826	137	V>A	No	EVA
rs230068560	141	V>M	No	EVA
rs3389579787	144	Q>K	No	EVA
rs13464455	148	I>M	No	EVA
rs3389532844	153	Q>*	No	EVA
rs3411044176	187	S>R	No	EVA
rs3410567003	192	L>H	No	EVA
rs262190641	202	M>K	No	EVA
rs3389557808	244	Q>H	No	EVA
rs3389560655	265	D>E	No	EVA
rs3410791322	269	R>V	No	EVA
rs3408352691	275	K>TFPEGILEQKPASFQCVA*	No	EVA
rs3411044132	361	Y>H	No	EVA
rs3412729484	363	N>I	No	EVA
rs3410826470	363	N>Y	No	EVA
rs3389520895	390	C>R	No	EVA
rs3389564136	391	E>K	No	EVA
rs240952421	404	A>V	No	EVA

Type	Name	Position	InterPro Accession
domain	RIO kinase	66 - 289	IPR000687
domain	RIO2 kinase winged helix domain, N-terminal	9 - 91	IPR015285
conserved_site	RIO kinase, conserved site	224 - 235	IPR018935
domain	Serine/threonine-protein kinase Rio2	94 - 276	IPR030484

		Description
EC Number	5.1.3.8	Acting on carbohydrates and derivatives
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
enzyme inhibitor activity	Binds to and stops, prevents or reduces the activity of an enzyme.
identical protein binding	Binding to an identical protein or proteins.
N-acylglucosamine 2-epimerase activity	Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine.
peptidase inhibitor activity	Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
purine nucleotide binding	Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate.

Name	Definition
carbohydrate metabolic process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
N-acetylglucosamine metabolic process	The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein.
N-acetylmannosamine metabolic process	The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose.
N-acetylneuraminate catabolic process	The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.
negative regulation of catalytic activity	Any process that stops or reduces the activity of an enzyme.
negative regulation of endopeptidase activity	Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2KIS1	RENBP	N-acylglucosamine 2-epimerase	Bos taurus (Bovine)	PR