P81900
PR
Gene name |
Pka-R2 |
Protein name |
cAMP-dependent protein kinase type II regulatory subunit |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG15862 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P81900
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P81900-F1 | Predicted | AlphaFoldDB |
No variants for P81900
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P81900 | |||||
No associated diseases with P81900
6 regional properties for P81900
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 124 - 240 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 242 - 362 | IPR000595-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 151 - 167 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 187 - 204 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 269 - 285 | IPR018488-3 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 309 - 326 | IPR018488-4 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cAMP-dependent protein kinase complex | An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cAMP-dependent protein kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. |
| protein kinase A catalytic subunit binding | Binding to one or both of the catalytic subunits of protein kinase A. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| behavioral response to cocaine | Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. |
| behavioral response to ethanol | Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus. |
| cellular response to ethanol | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| circadian rhythm | Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
| locomotor rhythm | The rhythm of the locomotor activity of an organism during its 24 hour activity cycle. |
| negative regulation of cAMP-dependent protein kinase activity | Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity. |
| rhythmic behavior | The specific behavior of an organism that recur with measured regularity. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07278 | BCY1 | cAMP-dependent protein kinase regulatory subunit | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| P00514 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| P31322 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | Bos taurus (Bovine) | EV |
| P00515 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| Q5ZM91 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Gallus gallus (Chicken) | SS |
| P16905 | Pka-R1 | cAMP-dependent protein kinase type I regulatory subunit | Drosophila melanogaster (Fruit fly) | PR |
| Q96M20 | CNBD2 | Cyclic nucleotide-binding domain-containing protein 2 | Homo sapiens (Human) | PR |
| P10644 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Homo sapiens (Human) | EV |
| P31321 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | Homo sapiens (Human) | EV |
| P13861 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Homo sapiens (Human) | PR |
| P31323 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | Homo sapiens (Human) | PR |
| Q9D5U8 | Cnbd2 | Cyclic nucleotide-binding domain-containing protein 2 | Mus musculus (Mouse) | PR |
| P12849 | Prkar1b | cAMP-dependent protein kinase type I-beta regulatory subunit | Mus musculus (Mouse) | PR |
| Q9DBC7 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed] | Mus musculus (Mouse) | SS |
| P31324 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Mus musculus (Mouse) | PR |
| P12367 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Mus musculus (Mouse) | PR |
| P05207 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P07802 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P81377 | Prkar1b | cAMP-dependent protein kinase type I-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P09456 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit | Rattus norvegicus (Rat) | SS |
| P12368 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Rattus norvegicus (Rat) | PR |
| P12369 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P30625 | kin-2 | cAMP-dependent protein kinase regulatory subunit | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSDSSRRIQ | VPEELKEVLL | QFSISFLVEQ | PPDVIDYAVE | YFTKLQSERP | SVSHTDQSTD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DQLSVNSQDA | DAEPPVMASS | RRKSVFAEAY | DPEADDDDDG | ATAVFPKTDE | QRARLVESVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NVLLFRSLEK | EQMNQVLDAM | FERKVQPGDF | IIRQGDDGDN | FYVIESGVYK | VYINDKHINT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YNHTGLFGEL | ALLYNMPRAA | TVQAETSGLL | WAMDRQTFRR | ILLKSAFRKR | KMYEELLNSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PMLKALQNYE | RMNLADALVS | KSYDNGERII | KQGDAADGMY | FIEEGTVSVR | MDQDDAEVEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SQLGKGQYFG | ELALVTHRPR | AASVYATGGV | VKLAFLDVKA | FERLLGPCMD | IMKRNIDDYE |
| 370 | |||||
| SQLVKIFGSK | NNITDTR |