P31322
Gene name |
PRKAR2B |
Protein name |
cAMP-dependent protein kinase type II-beta regulatory subunit |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:282463 |
EC number |
|
Protein Class |
CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN (PTHR11635) |
Descriptions
PKA is a major intracellular receptor of cAMP and modulates diverse cellular signalings. The N-terminal regulatory domain contains a pseudosubstrate sequence that may interact with the catalytic kinase domain.
Autoinhibitory domains (AIDs)
Target domain |
154-274 (Cyclic nucleotide-binding domain) |
Relief mechanism |
Ligand binding |
Assay |
Mutagenesis experiment |
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for P31322
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P31322-F1 | Predicted | AlphaFoldDB |
No variants for P31322
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P31322 | |||||
No associated diseases with P31322
7 regional properties for P31322
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 154 - 274 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 276 - 402 | IPR000595-2 |
| domain | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | 7 - 44 | IPR003117 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 181 - 197 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 221 - 238 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 303 - 319 | IPR018488-3 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 350 - 367 | IPR018488-4 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cAMP-dependent protein kinase complex | An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cAMP binding | Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). |
| cAMP-dependent protein kinase regulator activity | Modulation of the activity of the enzyme cAMP-dependent protein kinase. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of protein phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. |
22 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P00514 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| P00515 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Bos taurus (Bovine) | EV |
| Q5ZM91 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Gallus gallus (Chicken) | SS |
| P16905 | Pka-R1 | cAMP-dependent protein kinase type I regulatory subunit | Drosophila melanogaster (Fruit fly) | PR |
| P81900 | Pka-R2 | cAMP-dependent protein kinase type II regulatory subunit | Drosophila melanogaster (Fruit fly) | PR |
| P13861 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Homo sapiens (Human) | PR |
| Q96M20 | CNBD2 | Cyclic nucleotide-binding domain-containing protein 2 | Homo sapiens (Human) | PR |
| P10644 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Homo sapiens (Human) | EV |
| P31321 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | Homo sapiens (Human) | EV |
| P31323 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | Homo sapiens (Human) | PR |
| P12849 | Prkar1b | cAMP-dependent protein kinase type I-beta regulatory subunit | Mus musculus (Mouse) | PR |
| P12367 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Mus musculus (Mouse) | PR |
| Q9D5U8 | Cnbd2 | Cyclic nucleotide-binding domain-containing protein 2 | Mus musculus (Mouse) | PR |
| Q9DBC7 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed] | Mus musculus (Mouse) | SS |
| P31324 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Mus musculus (Mouse) | PR |
| P05207 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P07802 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | Sus scrofa (Pig) | SS |
| P12368 | Prkar2a | cAMP-dependent protein kinase type II-alpha regulatory subunit | Rattus norvegicus (Rat) | PR |
| P81377 | Prkar1b | cAMP-dependent protein kinase type I-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P09456 | Prkar1a | cAMP-dependent protein kinase type I-alpha regulatory subunit | Rattus norvegicus (Rat) | SS |
| P12369 | Prkar2b | cAMP-dependent protein kinase type II-beta regulatory subunit | Rattus norvegicus (Rat) | PR |
| P30625 | kin-2 | cAMP-dependent protein kinase regulatory subunit | Caenorhabditis elegans | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIEIPAGLT | ELLQGFTVEV | LRHQPADLLE | FALQHFTRLQ | EENERKGTAR | FGHEGRTWGD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGAAGGGGTP | SKGVNFAEEP | RHSDSENGEE | EEEEAADAGA | FNAPVINRFT | RRASVCAEAY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPDEEEDDAE | SRIIHPKTDD | QRNRLQEACK | DILLFKNLDP | EQMSQVLDAM | FEKLVKEGEH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIDQGDDGDN | FYVIDRGTFD | IYVKCDGVGR | CVGNYDNRGS | FGELALMYNT | PRAATITATS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGALWGLDRV | TFRRIIVKNN | AKKRKMYESF | IESLPFLKSL | EVSERLKVVD | VIGTKVYNDG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EQIIAQGDSA | DSFFIVESGE | VKITMKRKGK | SEVEENGAVE | IARCSRGQYF | GELALVTNKP |
| 370 | 380 | 390 | 400 | 410 | |
| RAASAHAIGT | VKCLAMDVQA | FERLLGPCME | IMKRNIATYE | EQLVALFGTN | MDIVEPTA |