P80645

PR
Gene name
ssuD
Protein name
Alkanesulfonate monooxygenase
Names
FMNH2-dependent aliphatic sulfonate monooxygenase, Sulfate starvation-induced protein 6, SSI6
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0935
EC number
1.14.14.5: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

329-381 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P80645

Entry ID Method Resolution Chain Position Source
1M41 X-ray 230 A A/B 2-381 PDB
1NQK X-ray 220 A A 1-381 PDB
AF-P80645-F1 Predicted AlphaFoldDB

1 variants for P80645

Variant ID(s) Position Change Description Diseaes Association Provenance
298 R>C strain: K12 / MC4100; inactive [UniProt] No

No associated diseases with P80645

1 regional properties for P80645

Type Name Position InterPro Accession
domain Luciferase-like domain 5 - 325 IPR011251

Functions

Description
EC Number 1.14.14.5 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
alkanesulfonate monooxygenase complex A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer.

1 GO annotations of molecular function

Name Definition
alkanesulfonate monooxygenase activity Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN.

3 GO annotations of biological process

Name Definition
alkanesulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.
cellular response to sulfur starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P75898 rutA Pyrimidine monooxygenase RutA Escherichia coli (strain K12) PR
10 20 30 40 50 60
MSLNMFWFLP THGDGHYLGT EEGSRPVDHG YLQQIAQAAD RLGYTGVLIP TGRSCEDAWL
70 80 90 100 110 120
VAASMIPVTQ RLKFLVALRP SVTSPTVAAR QAATLDRLSN GRALFNLVTG SDPQELAGDG
130 140 150 160 170 180
VFLDHSERYE ASAEFTQVWR RLLQRETVDF NGKHIHVRGA KLLFPAIQQP YPPLYFGGSS
190 200 210 220 230 240
DVAQELAAEQ VDLYLTWGEP PELVKEKIEQ VRAKAAAHGR KIRFGIRLHV IVRETNDEAW
250 260 270 280 290 300
QAAERLISHL DDETIAKAQA AFARTDSVGQ QRMAALHNGK RDNLEISPNL WAGVGLVRGG
310 320 330 340 350 360
AGTALVGDGP TVAARINEYA ALGIDSFVLS GYPHLEEAYR VGELLFPLLD VAIPEIPQPQ
370 380
PLNPQGEAVA NDFIPRKVAQ S