P75898

PR
Gene name
rutA (ycdM, b1012, JW0997)
Protein name
Pyrimidine monooxygenase RutA
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1012
EC number
1.14.99.46: Miscellaneous
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

261-339 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P75898

Entry ID Method Resolution Chain Position Source
5WAN X-ray 180 A A 2-382 PDB
6SGG X-ray 180 A AAA 20-382 PDB
6SGL X-ray 201 A AAA 19-382 PDB
6SGM X-ray 200 A AAA 20-382 PDB
6SGN X-ray 250 A AAA 20-382 PDB
6TEE X-ray 220 A AAA 20-382 PDB
6TEF X-ray 180 A AAA 19-382 PDB
6TEG X-ray 180 A AAA 19-382 PDB
AF-P75898-F1 Predicted AlphaFoldDB

No variants for P75898

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P75898

No associated diseases with P75898

1 regional properties for P75898

Type Name Position InterPro Accession
domain Luciferase-like domain 20 - 339 IPR011251

Functions

Description
EC Number 1.14.99.46 Miscellaneous
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
alkanesulfonate monooxygenase activity Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN.
monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
uracil oxygenase activity Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate.

5 GO annotations of biological process

Name Definition
alkanesulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.
nitrogen utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism.
pyrimidine nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
thymine catabolic process The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
uracil catabolic process The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P80645 ssuD Alkanesulfonate monooxygenase Escherichia coli (strain K12) PR
10 20 30 40 50 60
MQDAAPRLTF TLRDEERLMM KIGVFVPIGN NGWLISTHAP QYMPTFELNK AIVQKAEHYH
70 80 90 100 110 120
FDFALSMIKL RGFGGKTEFW DHNLESFTLM AGLAAVTSRI QIYATAATLT LPPAIVARMA
130 140 150 160 170 180
ATIDSISGGR FGVNLVTGWQ KPEYEQMGIW PGDDYFSRRY DYLTEYVQVL RDLWGTGKSD
190 200 210 220 230 240
FKGDFFTMND CRVSPQPSVP MKVICAGQSD AGMAFSARYA DFNFCFGKGV NTPTAFAPTA
250 260 270 280 290 300
ARMKQAAEQT GRDVGSYVLF MVIADETDDA ARAKWEHYKA GADEEALSWL TEQSQKDTRS
310 320 330 340 350 360
GTDTNVRQMA DPTSAVNINM GTLVGSYASV ARMLDEVASV PGAEGVLLTF DDFLSGIETF
370 380
GERIQPLMQC RAHLPALTQE VA