AiPD: Autoinhibited Protein Database

Gene name	Cct7 (Ccth)
Protein name	T-complex protein 1 subunit eta
Names	TCP-1-eta, CCT-eta
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:12468
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

494-544 (Predicted disordered autoinhibitory region) PR

494-544 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P80313-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs13470181	31	V>A	No	EVA
rs3388830101	59	S>T	No	EVA
rs13470185	122	I>T	No	EVA
rs232672930	142	T>S	No	EVA
rs585066890	155	L>M	No	EVA
rs3388842702	166	K>Q	No	EVA
rs3388844584	177	K>*	No	EVA
rs3388842057	179	V>L	No	EVA
rs3388823091	195	I>N	No	EVA
rs3388838064	201	Q>H	No	EVA
rs3388834345	237	I>N	No	EVA
rs3388827375	241	N>I	No	EVA
rs3388841980	252	N>I	No	EVA
rs3388830145	267	V>I	No	EVA
rs3388823024	274	L>I	No	EVA
rs3388847938	277	K>M	No	EVA
rs3388836621	281	I>N	No	EVA
rs3388830093	287	K>R	No	EVA
rs3388847965	309	F>V	No	EVA
rs3388834282	414	M>L	No	EVA
rs3388838042	424	S>P	No	EVA
rs3388844534	432	Q>*	No	EVA
rs3396583656	441	A>V	No	EVA
rs3388836565	472	G>S	No	EVA
rs3397055080	475	Y>*	No	EVA
rs3388844520	519	T>I	No	EVA
rs3388823017	528	D>E	No	EVA
rs3388844503	528	D>V	No	EVA
rs248375286	533	S>T	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P80313

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
chaperonin-containing T-complex	A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
protein folding chaperone	Binding to a protein or a protein-containing complex to assist the protein folding process.
unfolded protein binding	Binding to an unfolded protein.

Name	Definition
binding of sperm to zona pellucida	The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.
chaperone-mediated protein folding	The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
positive regulation of establishment of protein localization to telomere	Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
positive regulation of telomere maintenance via telomerase	Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
toxin transport	The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P42943	CCT7	T-complex protein 1 subunit eta	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P42932	Cct8	T-complex protein 1 subunit theta	Mus musculus (Mouse)	PR
P11983	Tcp1	T-complex protein 1 subunit alpha	Mus musculus (Mouse)	PR