P79381

PR
Gene name
EPHX1
Protein name
Epoxide hydrolase 1
Names
Epoxide hydratase, Microsomal epoxide hydrolase, mEH
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397639
EC number
3.3.2.9: Ether hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P79381

Entry ID Method Resolution Chain Position Source
AF-P79381-F1 Predicted AlphaFoldDB

No variants for P79381

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P79381

No associated diseases with P79381

3 regional properties for P79381

Type Name Position InterPro Accession
domain RNA recognition motif domain 191 - 270 IPR000504
domain Eukaryotic translation initiation factor 3 subunit G, N-terminal 7 - 126 IPR024675
domain eIF3G, RNA recognition motif 192 - 268 IPR034240

Functions

Description
EC Number 3.3.2.9 Ether hydrolases
Subcellular Localization
  • Microsome membrane ; Single-pass type III membrane protein
  • Endoplasmic reticulum membrane ; Single-pass type III membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
cis-stilbene-oxide hydrolase activity Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol.
epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol.

4 GO annotations of biological process

Name Definition
arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
epoxide metabolic process The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9D379 Ephx1 Epoxide hydrolase 1 Mus musculus (Mouse) PR
P07687 Ephx1 Epoxide hydrolase 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MWLEILLASV LGFVIYWFVS KDKEETLLLG DGWWGPGSRP AAAEDESIRP FKVETSDEEI
70 80 90 100 110 120
NDLHQRIEKF RLTPPLEDSR FHYGFNSNYL KKIISYWRNT FDWRKQVEVL NKYPHFKTKI
130 140 150 160 170 180
EGLDIHFIHV KPPQLPSGRT AKPLLMVHGW PGCFYEFYKI IPLLTDPKNH GLSDEHVFEV
190 200 210 220 230 240
ICPSIPGYGF SEASSKKGFN SVAAARIFYK LMLRLGFQEF YLQGGDWGSL ICTNMAQLVP
250 260 270 280 290 300
SHVKGLHLNV ALVLRNVYTL TFFLGRRLGR LFGYTERDLE LLYPFKKTFY TLMRESGYMH
310 320 330 340 350 360
IQSTKPDTVG CALNDSPVGL AAYILEKFST WTNEEFRDLE DGGLERKFSL DELLTVIMLY
370 380 390 400 410 420
WTTGTITSSQ RFYKENLGQG VMANKHEAIK VHVPTGFAAF PSEVLHCPEK WVKNKYPKLI
430 440 450
SYSYMARGGH FAAFEEPELL AQDIRKFMGL LEQQ