P76542

PR
Gene name
intZ (b2442)
Protein name
Prophage integrase IntZ
Names
Putative prophage CPZ-55 integrase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2442
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P76542

Entry ID Method Resolution Chain Position Source
AF-P76542-F1 Predicted AlphaFoldDB

No variants for P76542

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P76542

No associated diseases with P76542

3 regional properties for P76542

Type Name Position InterPro Accession
domain Integrase, catalytic domain 206 - 381 IPR002104
domain Integrase, DNA-binding domain 6 - 92 IPR025166
domain Core-binding (CB) domain 103 - 183 IPR044068

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

5 GO annotations of biological process

Name Definition
DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
establishment of integrated proviral latency A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
viral genome integration into host DNA The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P71298 intF Prophage integrase IntF Escherichia coli (strain K12) PR
P39347 intB Putative protein IntB Escherichia coli (strain K12) PR
10 20 30 40 50 60
MSKTPLTAKA IDAAQPQDKP YKLTDSLTPG LFLLVHPNGS KYWRFRYWLN KREFLQAIGV
70 80 90 100 110 120
YPLITLKEAR RRATESRSLI ANGINPVEQA RKEKAIDALN MAAGFKKVAE DWFATRVGGW
130 140 150 160 170 180
SESYAKQVRS ALEKDVYPVL GKRSIVDITA RDVLALLQKK ERTAPEQARK LRRRIGEIFK
190 200 210 220 230 240
FAVITELVTR NPVADLDTAL KARRPGHNAW IPISEIPAFY KALERAGSVQ IQTAIRLLIL
250 260 270 280 290 300
TALRTAELRL CRWEWINLED ATITLPAEVM KARRPHVVPL SRQAVELLQD QFTRSGYSAF
310 320 330 340 350 360
VFPGRFMDKP LSASAILKAL ERIGYKSIAT GHGWRTTFST ALNESGRYSP DWIEIQLAHV
370 380 390 400
PKGIRGVYNQ AAYLKQRRAM MQDYADAIDS ILAGNGNPLE PE