Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P71298

Entry ID Method Resolution Chain Position Source
AF-P71298-F1 Predicted AlphaFoldDB

No variants for P71298

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P71298

No associated diseases with P71298

3 regional properties for P71298

Type Name Position InterPro Accession
domain Integrase, catalytic domain 268 - 445 IPR002104
domain Integrase, DNA-binding domain 56 - 119 IPR025166
domain Core-binding (CB) domain 134 - 239 IPR044068

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

6 GO annotations of biological process

Name Definition
DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
establishment of integrated proviral latency A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
response to X-ray Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
viral genome integration into host DNA The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39347 intB Putative protein IntB Escherichia coli (strain K12) PR
P76542 intZ Prophage integrase IntZ Escherichia coli (strain K12) PR
10 20 30 40 50 60
MFIPSIYLHQ QLHYCKTAIL NWSRKMALSR QKFTFERLRR FTLPEGKKQT FLWDADVTTL
70 80 90 100 110 120
ACRATSGAKA FVFQSVYAGK TLRMTIGNIN DWKIDDARAE ARRLQTLIDT GIDPRIAKAV
130 140 150 160 170 180
KIAEAESLQA ESRKTKVTFS VAWEDYLQEL RTGISAKTKR PYSTRYIADH INLSSRGGES
190 200 210 220 230 240
KKRGQGPTSA GPLASLLNLP LSELTPDYIA AWLSTERQNR PTVTAHAYRL LRAFIKWSNY
250 260 270 280 290 300
QKKYQGIIPG DLAQDYNVRK MVPVSASKAD DCLQKEQLKS WFSAVRSLNN PIASAYLQVL
310 320 330 340 350 360
LLTGARREEI ASLRWSDVDF KWSSMRIKDK IEGERIIPLT PYVSELLNVL AQSPNSDVNK
370 380 390 400 410 420
EGWVFRSNSK SGKIIEPRSA HNRALVLAEL PHISLHGLRR SFGTLAEWVE VPTGIVAQIM
430 440 450 460
GHKPSALAEK HYRRRPLDLL RKWHEKIETW ILNEAGITIK NNVDMR