P76397

PR
Gene name
mdtA (yegM, b2074, JW5338)
Protein name
Multidrug resistance protein MdtA
Names
Multidrug transporter MdtA
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2074
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P76397

Entry ID Method Resolution Chain Position Source
AF-P76397-F1 Predicted AlphaFoldDB

No variants for P76397

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P76397

No associated diseases with P76397

1 regional properties for P76397

Type Name Position InterPro Accession
domain Membrane fusion protein, biotin-lipoyl like domain 87 - 135 IPR039562

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
efflux pump complex A protein complex that is capable of efflux transmembrane transporter activity.
periplasmic side of plasma membrane The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface.

2 GO annotations of molecular function

Name Definition
bile acid transmembrane transporter activity Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

3 GO annotations of biological process

Name Definition
bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
xenobiotic detoxification by transmembrane export across the cell outer membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane.
xenobiotic transport The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P75830 macA Macrolide export protein MacA Escherichia coli (strain K12) PR
10 20 30 40 50 60
MKGSYKSRWV IVIVVVIAAI AAFWFWQGRN DSRSAAPGAT KQAQQSPAGG RRGMRSGPLA
70 80 90 100 110 120
PVQAATAVEQ AVPRYLTGLG TITAANTVTV RSRVDGQLIA LHFQEGQQVK AGDLLAEIDP
130 140 150 160 170 180
SQFKVALAQA QGQLAKDKAT LANARRDLAR YQQLAKTNLV SRQELDAQQA LVSETEGTIK
190 200 210 220 230 240
ADEASVASAQ LQLDWSRITA PVDGRVGLKQ VDVGNQISSG DTTGIVVITQ THPIDLVFTL
250 260 270 280 290 300
PESDIATVVQ AQKAGKPLVV EAWDRTNSKK LSEGTLLSLD NQIDATTGTI KVKARFNNQD
310 320 330 340 350 360
DALFPNQFVN ARMLVDTEQN AVVIPTAALQ MGNEGHFVWV LNSENKVSKH LVTPGIQDSQ
370 380 390 400 410
KVVIRAGISA GDRVVTDGID RLTEGAKVEV VEAQSATTPE EKATSREYAK KGARS