P75830

PR
Gene name
macA (ybjY, b0878, JW0862)
Protein name
Macrolide export protein MacA
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0878
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

74-173 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P75830

Entry ID Method Resolution Chain Position Source
3FPP X-ray 299 A A/B 31-371 PDB
5NIK EM 330 A D/E/F/G/H/I 1-371 PDB
5NIL EM 530 A D/E/F/G/H/I 1-371 PDB
AF-P75830-F1 Predicted AlphaFoldDB

No variants for P75830

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P75830

No associated diseases with P75830

1 regional properties for P75830

Type Name Position InterPro Accession
domain RND efflux pump, membrane fusion protein, barrel-sandwich domain 47 - 294 IPR032317

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Single-pass membrane protein ; Periplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
efflux pump complex A protein complex that is capable of efflux transmembrane transporter activity.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
MacAB-TolC complex The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
identical protein binding Binding to an identical protein or proteins.

2 GO annotations of biological process

Name Definition
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
xenobiotic detoxification by transmembrane export across the plasma membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P76397 mdtA Multidrug resistance protein MdtA Escherichia coli (strain K12) PR
10 20 30 40 50 60
MKKRKTVKKR YVIALVIVIA GLITLWRILN APVPTYQTLI VRPGDLQQSV LATGKLDALR
70 80 90 100 110 120
KVDVGAQVSG QLKTLSVAIG DKVKKDQLLG VIDPEQAENQ IKEVEATLME LRAQRQQAEA
130 140 150 160 170 180
ELKLARVTYS RQQRLAQTKA VSQQDLDTAA TEMAVKQAQI GTIDAQIKRN QASLDTAKTN
190 200 210 220 230 240
LDYTRIVAPM AGEVTQITTL QGQTVIAAQQ APNILTLADM SAMLVKAQVS EADVIHLKPG
250 260 270 280 290 300
QKAWFTVLGD PLTRYEGQIK DVLPTPEKVN DAIFYYARFE VPNPNGLLRL DMTAQVHIQL
310 320 330 340 350 360
TDVKNVLTIP LSALGDPVGD NRYKVKLLRN GETREREVTI GARNDTDVEI VKGLEAGDEV
370
VIGEAKPGAA Q