AiPD: Autoinhibited Protein Database

Gene name	Trpv5
Protein name	Transient receptor potential cation channel subfamily V member 5
Names	TrpV5, Calcium transport protein 2, CaT2, Epithelial calcium channel 1, ECaC1, Osm-9-like TRP channel 3, OTRPC3
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:194352
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

616-723 (Predicted disordered autoinhibitory region) PR

616-723 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P69744-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388827604	39	W>R	No	EVA
rs234112065	63	N>S	No	EVA
rs3388825631	65	D>E	No	EVA
rs3388829249	126	L>Q	No	EVA
rs3388815513	142	T>A	No	EVA
rs3388825694	143	G>V	No	EVA
rs3388829286	167	V>SDG*	No	EVA
rs3388793051	170	E>V	No	EVA
rs3388818779	179	H>Y	No	EVA
rs3388832208	203	K>R	No	EVA
rs3388810055	228	V>M	No	EVA
rs3388823578	232	Q>R	No	EVA
rs3388823396	268	S>F	No	EVA
rs3388823363	273	L>H	No	EVA
rs3396276964	298	R>H	No	EVA
rs3388823553	403	V>F	No	EVA
rs3388818802	447	M>L	No	EVA
rs3388823586	455	W>*	No	EVA
rs3388823534	470	P>A	No	EVA
rs3388818750	504	I>V	No	EVA
rs3388819494	530	F>L	No	EVA
rs3388823559	562	L>F	No	EVA
rs3388825170	602	P>T	No	EVA
rs3388818765	617	G>C	No	EVA
rs3388829232	663	G>V	No	EVA
rs229832871	712	P>L	No	EVA
rs3388812677	714	E>*	No	EVA

Type	Name	Position	InterPro Accession
repeat	Ankyrin repeat	72 - 102	IPR002110-1
repeat	Ankyrin repeat	110 - 188	IPR002110-2
repeat	Ankyrin repeat	232 - 261	IPR002110-3
domain	Ion transport domain	330 - 582	IPR005821

		Description
EC Number
Subcellular Localization	Apical cell membrane ; Multi-pass membrane protein	Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
calcium channel complex	An ion channel complex through which calcium ions pass.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intrinsic component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.

Name	Definition
calcium channel activity	Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
calmodulin binding	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
ion channel activity	Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
metal ion binding	Binding to a metal ion.

Name	Definition
calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
calcium ion import across plasma membrane	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol.
calcium ion transmembrane transport	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
calcium ion transport	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
calcium ion transport into cytosol	The directed movement of calcium ions (Ca2+) into the cytosol.
cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
protein homotetramerization	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
regulation of urine volume	Any process that modulates the amount of urine excreted from the body over a unit of time.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NQA5	TRPV5	Transient receptor potential cation channel subfamily V member 5	Homo sapiens (Human)	PR