P58058

PR
Gene name
Nadk
Protein name
NAD kinase
Names
Poly(P)/ATP NAD kinase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:192185
EC number
2.7.1.23: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58058

Entry ID Method Resolution Chain Position Source
AF-P58058-F1 Predicted AlphaFoldDB

19 variants for P58058

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388745278 11 S>N No EVA
rs3388739175 19 A>V No EVA
rs3388740496 48 S>P No EVA
rs3388740181 62 T>S No EVA
rs3388740532 63 R>L No EVA
rs3395199395 86 T>A No EVA
rs3388733548 155 F>V No EVA
rs3388736298 157 P>Q No EVA
rs3388733146 158 V>G No EVA
rs3395032182 191 A>T No EVA
rs3388733569 203 M>T No EVA
rs3388733122 220 N>K No EVA
rs3388740693 250 R>S No EVA
rs3388745301 254 T>R No EVA
rs3388740205 279 L>F No EVA
rs3388745269 307 V>E No EVA
rs3388736248 331 M>K No EVA
rs3413118832 349 L>M No EVA
rs3394587422 397 S>F No EVA

No associated diseases with P58058

No regional properties for P58058

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P58058

Functions

Description
EC Number 2.7.1.23 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
NAD+ kinase activity Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+).

4 GO annotations of biological process

Name Definition
NAD metabolic process The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
NADP biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of insulin secretion involved in cellular response to glucose stimulus Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O95544 NADK NAD kinase Homo sapiens (Human) PR
10 20 30 40 50 60
MEMEQEKMNL SQELSADSAS YNCSACHGDE TWSYNHPIRG RAKSRSLSAS PALGSTKEFR
70 80 90 100 110 120
RTRSLHGPCP VTTFGPKACV LQNPQTIMHI QDPASQRLTW NKSPKSVLVI KKIRDASLLQ
130 140 150 160 170 180
PFKELCIYLM EENNMIVYVE KKVLEDPAIV SDENFGPVKK KFCTFREDYD DISNQIDFII
190 200 210 220 230 240
CLGGDGTLLY ASSLFQGSVP PVMAFHLGSL GFLTPFNFEN FQSQVNQVIE GNAAVILRSR
250 260 270 280 290 300
LKVRVVKEPR DKKTAIHNGL SENGLDTEGG KQAMQYQVLN EVVIDRGPSS YLSNVDVYLD
310 320 330 340 350 360
GHLITTVQGD GVIVSTPTGS TAYAAAAGAS MVHPNVPAIM VTPICPHSLS FRPIVVPAGV
370 380 390 400 410 420
ELKIMLSPEA RNTAWVSFDG RKRQEIRHGD SISITTSCYP LPSICVCDPV SDWFESLAQC
430
LHWNVRKKQA HFPEDEEDS