O95544
PR
Gene name |
NADK |
Protein name |
NAD kinase |
Names |
Poly(P)/ATP NAD kinase |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:65220 |
EC number |
2.7.1.23: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O95544
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3PFN | X-ray | 270 A | A/B/C/D | 68-426 | PDB |
| AF-O95544-F1 | Predicted | AlphaFoldDB |
302 variants for O95544
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs945313437 CA16849781 |
2 | E>K | No |
ClinGen gnomAD |
|
|
rs1178021001 CA337939996 |
3 | M>I | No |
ClinGen TOPMed |
|
|
CA531874 rs780271246 |
3 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA337939974 rs1438416264 |
5 | Q>E | No |
ClinGen TOPMed |
|
|
CA16849762 rs375061907 |
6 | E>D | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs750827964 CA531872 |
8 | M>I | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 8 | M>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA337939920 rs1416139383 |
8 | M>T | No |
ClinGen gnomAD |
|
| TCGA novel | 9 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA337939891 rs201083151 |
10 | M>R | No |
ClinGen 1000Genomes gnomAD |
|
|
CA16849739 rs201083151 |
10 | M>T | No |
ClinGen 1000Genomes gnomAD |
|
|
CA531871 rs766419897 |
10 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA337939320 rs1173076390 |
13 | E>V | No |
ClinGen gnomAD |
|
|
rs540868877 CA531870 |
17 | D>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA337939270 rs1477120576 |
17 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
CA531869 rs751046422 |
18 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA16849727 rs910313865 |
18 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs762585014 CA531867 |
19 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1481084157 CA337939207 |
21 | Y>* | No |
ClinGen gnomAD |
|
|
CA531865 rs141373333 |
23 | C>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs759409953 CA531864 |
23 | C>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748296163 CA531863 |
24 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337939166 rs1352957585 |
25 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs202107698 CA16849616 |
25 | A>V | No |
ClinGen TOPMed |
|
|
rs961640986 CA16849612 |
27 | H>R | No |
ClinGen TOPMed |
|
|
rs373135938 CA337939129 |
28 | G>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
COSM1336154 CA531861 rs373135938 |
28 | G>S | salivary_gland Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA531857 rs201229178 |
29 | D>N | Variant assessed as Somatic; 0.0003234 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA531858 rs201229178 |
29 | D>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA531856 rs780329303 |
34 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
rs1472750272 CA891518339 |
34 | Y>* | No |
ClinGen TOPMed |
|
|
CA337939020 rs1570555276 |
35 | N>T | No |
ClinGen Ensembl |
|
|
rs1236100129 CA337938993 |
36 | H>D | No |
ClinGen TOPMed |
|
|
rs1570555240 CA337938986 |
36 | H>P | No |
ClinGen Ensembl |
|
|
rs1195701371 CA337938964 |
38 | I>N | No |
ClinGen TOPMed |
|
| TCGA novel | 38 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs746264887 CA531854 |
39 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755581382 CA531855 |
39 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs370296753 CA531852 |
41 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA16849589 rs370296753 |
41 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA531853 rs781458015 |
41 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA16849588 rs865799939 |
42 | A>T | No |
ClinGen Ensembl |
|
|
CA531851 rs752122671 |
45 | R>C | No |
ClinGen ExAC gnomAD |
|
|
CA337938930 rs752122671 |
45 | R>G | No |
ClinGen ExAC gnomAD |
|
|
COSM3976483 CA531850 rs377478067 |
45 | R>H | lung Variant assessed as Somatic; 4.624e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs757913387 CA531849 |
51 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs764966748 CA531847 |
52 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA531845 rs753641611 |
55 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1297863002 CA337938869 |
55 | S>R | No |
ClinGen TOPMed |
|
|
rs369515511 CA531844 |
56 | T>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA531843 rs201617066 |
57 | K>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA337938810 rs1269079044 |
62 | T>R | No |
ClinGen TOPMed |
|
|
rs532541185 CA531814 |
63 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs532541185 CA337938808 |
63 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA531813 rs776728824 |
63 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs771216147 CA531812 |
64 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1234472785 CA337938768 |
69 | C>F | No |
ClinGen TOPMed |
|
|
rs894749639 CA16846151 |
70 | P>L | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 71 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA531809 rs772541412 |
78 | A>G | No |
ClinGen ExAC |
|
|
rs1384343524 CA337938681 |
83 | N>D | No |
ClinGen TOPMed |
|
| TCGA novel | 85 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 87 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs747797665 CA531630 |
88 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA531629 rs778452853 |
89 | H>D | No |
ClinGen ExAC gnomAD |
|
|
CA337936412 rs1557839693 |
92 | D>A | No |
ClinGen Ensembl |
|
|
rs1224694864 CA337936402 |
94 | A>T | No |
ClinGen TOPMed |
|
|
rs372709284 CA531624 |
95 | S>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs764164786 CA531623 |
95 | S>R | No |
ClinGen ExAC TOPMed |
|
|
rs752911055 CA531621 |
97 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1335212018 CA337936381 |
97 | R>W | No |
ClinGen gnomAD |
|
|
CA531619 rs573640938 |
99 | T>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA531616 rs145393948 |
107 | V>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 118 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs773625251 CA531614 |
119 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs1458132570 CA337936036 |
121 | P>L | No |
ClinGen gnomAD |
|
|
CA531610 rs768423416 |
122 | F>I | No |
ClinGen ExAC gnomAD |
|
|
rs1570517698 CA337935969 |
126 | C>Y | No |
ClinGen Ensembl |
|
|
COSM1258671 COSM1258672 rs749009504 CA531609 |
127 | T>M | oesophagus [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA531607 rs755975349 |
128 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA337935941 rs1245652533 |
130 | M>R | No |
ClinGen TOPMed gnomAD |
|
|
CA337935942 rs1245652533 |
130 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
CA337935894 rs1312027986 |
131 | E>G | No |
ClinGen gnomAD |
|
|
rs1378142023 CA337935901 |
131 | E>K | No |
ClinGen gnomAD |
|
|
CA337935289 rs1398225232 |
132 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1557837982 CA337935279 |
133 | N>S | No |
ClinGen Ensembl |
|
|
CA337935254 rs1197534818 |
135 | I>V | No |
ClinGen gnomAD |
|
|
rs1490265077 CA337935236 |
136 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
COSM1472951 rs1490265077 COSM1472952 CA337935238 |
136 | V>M | Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA531510 rs374090651 |
143 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA531509 rs147892956 |
146 | P>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs147892956 CA531508 |
146 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA16837871 rs1010981575 |
147 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA337935092 rs1325065325 |
147 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs767263687 CA531507 |
148 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768603667 CA531504 |
149 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA531505 rs200152611 |
149 | A>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA531502 rs776756207 |
152 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337934972 rs1278026393 |
156 | A>V | No |
ClinGen Ensembl |
|
|
CA337934968 rs1161759576 |
157 | V>M | No |
ClinGen TOPMed |
|
|
rs771146301 CA531501 |
160 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA16837831 rs965784613 |
165 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA531499 rs772515992 |
165 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA531498 rs772515992 |
165 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA16837577 rs1022452747 |
167 | D>E | No |
ClinGen TOPMed |
|
|
rs563917740 CA531473 |
167 | D>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1272583084 CA337934775 |
173 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
CA16837567 rs746639025 |
175 | I>M | No |
ClinGen Ensembl |
|
|
rs1201991688 CA337934758 |
175 | I>T | No |
ClinGen gnomAD |
|
|
CA337934749 rs780564992 |
177 | F>I | No |
ClinGen ExAC gnomAD |
|
|
CA531472 rs780564992 |
177 | F>V | No |
ClinGen ExAC gnomAD |
|
|
rs745346902 CA531470 |
178 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs751182182 CA531467 |
182 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA16837530 rs772219400 CA337934715 |
182 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs751182182 CA531468 |
182 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763881562 CA531466 |
183 | G>A | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 183 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758157339 CA337934701 |
184 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337934689 rs1182911931 |
186 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA531463 rs765243431 |
189 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA531461 rs773412415 |
190 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs1265614547 CA337934671 |
190 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA531459 rs762029796 |
192 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA337934642 rs1363020329 |
194 | F>L | No |
ClinGen TOPMed |
|
|
rs769018706 CA531457 |
195 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs771617462 CA531414 |
198 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs772539818 CA531415 |
198 | V>I | No |
ClinGen ExAC gnomAD |
|
|
rs1029258396 CA16836518 |
200 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA337934581 rs1243395425 |
202 | M>I | No |
ClinGen TOPMed |
|
|
rs1557835681 CA337934586 |
202 | M>V | No |
ClinGen Ensembl |
|
|
CA531411 rs768474573 |
205 | H>Y | No |
ClinGen ExAC gnomAD |
|
|
CA531408 rs755987414 |
207 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs745827627 CA531407 |
213 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1322495925 CA337934494 |
216 | S>T | No |
ClinGen TOPMed |
|
|
CA531406 rs777644499 |
217 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs1449279914 CA337934483 |
218 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1449279914 CA337934482 |
218 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1244239954 CA337934469 |
219 | N>K | No |
ClinGen gnomAD |
|
|
rs767918363 CA531405 |
220 | F>S | No |
ClinGen ExAC gnomAD |
|
|
rs201837992 CA531403 |
221 | Q>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs765421829 CA531402 |
222 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA337934452 rs1441700508 |
222 | S>P | No |
ClinGen Ensembl |
|
|
CA337934429 rs1318294332 |
225 | T>I | No |
ClinGen TOPMed |
|
| TCGA novel | 226 | Q>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs766780187 CA531399 |
228 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA531374 rs763714307 |
231 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA531372 rs775236595 |
232 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337933905 rs1323543424 |
234 | V>A | No |
ClinGen gnomAD |
|
|
CA531371 rs769424082 |
234 | V>I | No |
ClinGen ExAC gnomAD |
|
|
COSM116897 rs139648414 CA531370 |
237 | R>Q | ovary [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
rs936564493 CA16835632 |
239 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs746695294 CA16835636 |
239 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA531368 rs373767547 |
243 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA337933811 rs1465102638 |
243 | R>T | No |
ClinGen TOPMed |
|
|
CA337933789 rs1160405005 |
245 | V>A | No |
ClinGen gnomAD |
|
|
rs1225398403 CA337933776 |
246 | K>N | No |
ClinGen gnomAD |
|
|
CA531367 rs142307360 |
247 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA531365 rs75816936 |
249 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs376387032 CA531363 |
249 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA531364 rs75816936 |
249 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA337933734 rs1434690669 |
250 | G>E | No |
ClinGen gnomAD |
|
|
CA337933740 rs1245227942 |
250 | G>R | No |
ClinGen TOPMed |
|
|
CA337933726 rs1380459353 |
251 | K>Q | No |
ClinGen TOPMed |
|
|
rs750798946 CA531361 |
251 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781729596 CA531360 |
252 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA337933695 rs1158577988 |
253 | T>M | No |
ClinGen gnomAD |
|
|
CA16835592 rs868560477 |
254 | A>V | No |
ClinGen TOPMed |
|
|
rs759176849 CA531353 |
255 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA531355 rs147116706 |
255 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA531354 rs147116706 |
255 | V>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs776397399 CA531352 |
257 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1450504635 CA337933623 |
260 | G>A | No |
ClinGen TOPMed |
|
|
CA16835519 rs952363450 |
260 | G>R | No |
ClinGen TOPMed |
|
|
CA531348 CA16835517 rs4751 VAR_034119 |
262 | N>K | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA531347 rs749358997 |
263 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA531346 rs780067155 |
264 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA531343 rs757723692 |
265 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337933560 rs1367323772 |
265 | Q>P | No |
ClinGen gnomAD |
|
|
CA531341 rs200480601 |
266 | A>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1328742897 CA337933550 |
266 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
CA531339 rs141009211 |
268 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs752246521 CA337933510 |
270 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs752246521 CA531338 |
270 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA531337 rs764712671 |
271 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1174216804 CA337933499 |
271 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1188092589 CA337933481 |
272 | D>G | No |
ClinGen gnomAD |
|
|
rs754601133 CA531336 |
272 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA337933467 rs1474315493 |
274 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
CA337933450 rs1247275835 |
275 | K>R | No |
ClinGen gnomAD |
|
|
CA531334 rs139056453 |
277 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA337933404 rs1363739827 |
279 | Q>K | No |
ClinGen TOPMed |
|
|
CA337933398 rs1171052608 |
279 | Q>P | No |
ClinGen TOPMed |
|
|
rs1557833433 CA337933364 |
281 | Q>H | No |
ClinGen Ensembl |
|
|
rs149269930 CA531298 |
288 | I>F | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA337933206 rs1399642019 |
292 | P>R | No |
ClinGen TOPMed |
|
|
CA531296 rs748790016 |
292 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs1445163006 | 294 | S>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1024457971 CA16835145 |
294 | S>P | No |
ClinGen TOPMed gnomAD |
|
|
rs750077864 CA531293 |
296 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA531292 rs780995813 |
298 | N>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 303 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA337933034 rs1429497327 |
305 | G>R | No |
ClinGen gnomAD |
|
|
rs374339403 CA337933007 |
306 | H>Q | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA337933017 rs1435272538 |
306 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA16835109 rs371296905 |
307 | L>F | No |
ClinGen ESP TOPMed |
|
|
COSM899199 CA337932964 rs1270606632 COSM1151900 |
310 | T>M | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA337932960 rs1270606632 |
310 | T>R | No |
ClinGen gnomAD |
|
|
CA337932949 rs1282234984 |
312 | Q>E | No |
ClinGen TOPMed |
|
|
CA337932940 rs1328597773 |
312 | Q>H | No |
ClinGen gnomAD |
|
|
rs1390848300 CA337932906 |
315 | G>R | No |
ClinGen gnomAD |
|
|
CA531260 rs770339120 |
317 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1440795418 CA337932834 |
318 | V>A | No |
ClinGen gnomAD |
|
|
CA531257 CA531258 rs780824098 |
318 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA337932838 rs780824098 |
318 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1570498203 CA337932819 |
320 | T>A | No |
ClinGen Ensembl |
|
| TCGA novel | 320 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758300151 CA531253 |
326 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1364344087 CA337932722 |
328 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
COSM175511 rs750455546 CA531249 |
330 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs767646767 CA531248 |
330 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764390503 CA531245 |
332 | G>A | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 332 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA531244 rs538580250 |
335 | M>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA531243 rs775878184 |
338 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs566351993 CA531242 |
339 | N>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA337932587 rs1471814379 |
339 | N>S | No |
ClinGen gnomAD |
|
|
rs1220988910 CA337932571 |
340 | V>G | No |
ClinGen TOPMed |
|
|
rs1182769396 CA337932579 |
340 | V>M | No |
ClinGen gnomAD |
|
|
CA531240 rs775948949 |
341 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs373077528 CA531238 |
343 | I>V | No |
ClinGen ESP ExAC |
|
|
rs773021672 CA531237 |
344 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA16834880 rs553496562 |
344 | M>V | No |
ClinGen Ensembl |
|
|
CA337932502 rs1378870655 |
345 | I>M | No |
ClinGen gnomAD |
|
|
rs747952693 CA531235 |
347 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1226599572 CA337932477 |
348 | I>V | No |
ClinGen gnomAD |
|
|
rs1348197141 CA337932432 |
351 | H>L | No |
ClinGen gnomAD |
|
|
CA531232 rs749249829 |
351 | H>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 351 | H>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA337932374 rs1326090528 |
356 | R>W | No |
ClinGen gnomAD |
|
|
CA531230 rs781089281 |
357 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA16834795 rs535936720 |
359 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes NCI-TCGA gnomAD |
|
rs145224339 CA531227 |
362 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA531224 rs765650432 |
365 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA531225 rs753050279 COSM1583741 COSM899196 |
365 | E>K | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs759894955 CA531223 |
366 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA337932166 rs1363092769 |
368 | I>V | No |
ClinGen gnomAD |
|
|
CA16834393 rs200161241 |
373 | E>G | No |
ClinGen Ensembl |
|
|
rs901060505 CA16834392 |
374 | A>S | No |
ClinGen gnomAD |
|
|
CA531200 rs761321804 |
377 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs749892790 CA531199 |
380 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA531198 rs767139258 |
382 | F>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA531196 rs774072680 |
385 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA531197 rs761513924 |
385 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
| TCGA novel | 386 | K>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA531194 rs762775237 |
386 | K>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 389 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA531192 rs375840869 |
391 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs745822244 CA531191 |
391 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA337931900 rs1231219288 |
393 | G>E | No |
ClinGen gnomAD |
|
|
CA337931894 rs1340610689 |
394 | D>Y | No |
ClinGen gnomAD |
|
|
rs780425124 CA531164 |
397 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs1250330407 CA337930800 |
399 | T>A | No |
ClinGen gnomAD |
|
|
CA337930764 rs1264223548 |
401 | S>T | No |
ClinGen gnomAD |
|
|
CA337930694 rs1245435586 |
404 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA16832344 rs778633688 |
406 | P>L | No |
ClinGen Ensembl |
|
|
CA337930675 rs1226856140 |
406 | P>S | No |
ClinGen gnomAD |
|
|
CA16832343 rs911072972 |
407 | S>F | No |
ClinGen gnomAD |
|
|
rs1570490411 CA337930650 |
408 | I>L | No |
ClinGen Ensembl |
|
|
rs757901699 CA531159 |
409 | C>R | No |
ClinGen ExAC TOPMed |
|
|
CA337930625 rs1457248267 |
411 | R>Q | No |
ClinGen gnomAD |
|
|
COSM3740807 COSM3740808 CA531158 rs751071301 |
411 | R>W | Variant assessed as Somatic; 0.0 impact. liver [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA531157 COSM146376 rs763529709 |
414 | V>M | stomach [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA531156 rs367928288 |
415 | S>N | No |
ClinGen ESP ExAC gnomAD |
|
|
rs752326074 CA531155 |
416 | D>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 419 | E>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA337930451 rs1226795389 |
420 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs956253216 CA16832291 |
420 | S>R | No |
ClinGen TOPMed |
|
|
rs1557829324 CA337930396 |
423 | Q>H | No |
ClinGen Ensembl |
|
|
CA531150 COSM1196702 rs760542689 COSM1196703 |
429 | V>I | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA531151 rs760542689 |
429 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA531149 rs774421787 |
430 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM899191 CA337930276 COSM1151899 rs1557829238 |
430 | R>W | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
CA337930255 rs961108512 |
432 | K>E | No |
ClinGen gnomAD |
|
|
CA16832264 rs961108512 |
432 | K>Q | No |
ClinGen gnomAD |
|
|
rs1235071021 CA337930244 |
433 | Q>P | No |
ClinGen gnomAD |
|
|
rs1310224016 CA337930237 |
434 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1310224016 CA337930235 |
434 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1300499182 CA337930223 |
435 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1290524875 CA337930230 |
435 | H>Y | No |
ClinGen gnomAD |
|
|
rs768647366 CA531148 |
436 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA531147 rs144140745 |
436 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA337930191 rs1318007113 |
437 | E>Q | No |
ClinGen gnomAD |
|
|
CA337930172 rs1327979411 |
438 | E>Q | No |
ClinGen Ensembl |
|
|
rs531186303 CA16832247 |
439 | E>D | No |
ClinGen ExAC TOPMed |
|
|
CA337930142 rs1470671507 |
439 | E>G | No |
ClinGen TOPMed |
|
|
CA337930128 rs1034499085 |
440 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
CA16832240 rs1034499085 |
440 | E>K | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 442 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA531138 rs139135464 |
445 | E>* | No |
ClinGen ExAC TOPMed |
|
|
CA337929998 rs1376341482 |
445 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
rs770179015 CA531141 |
445 | E>G | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs781726371 CA531139 |
446 | G>S | No |
ClinGen ExAC |
No associated diseases with O95544
No regional properties for O95544
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O95544 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.23 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| metal ion binding | Binding to a metal ion. |
| NAD+ kinase activity | Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| ATP metabolic process | The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. |
| NAD metabolic process | The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid. |
| NADP biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P58058 | Nadk | NAD kinase | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEMEQEKMTM | NKELSPDAAA | YCCSACHGDE | TWSYNHPIRG | RAKSRSLSAS | PALGSTKEFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTRSLHGPCP | VTTFGPKACV | LQNPQTIMHI | QDPASQRLTW | NKSPKSVLVI | KKMRDASLLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PFKELCTHLM | EENMIVYVEK | KVLEDPAIAS | DESFGAVKKK | FCTFREDYDD | ISNQIDFIIC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LGGDGTLLYA | SSLFQGSVPP | VMAFHLGSLG | FLTPFSFENF | QSQVTQVIEG | NAAVVLRSRL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KVRVVKELRG | KKTAVHNGLG | ENGSQAAGLD | MDVGKQAMQY | QVLNEVVIDR | GPSSYLSNVD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VYLDGHLITT | VQGDGVIVST | PTGSTAYAAA | AGASMIHPNV | PAIMITPICP | HSLSFRPIVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PAGVELKIML | SPEARNTAWV | SFDGRKRQEI | RHGDSISITT | SCYPLPSICV | RDPVSDWFES |
| 430 | 440 | ||||
| LAQCLHWNVR | KKQAHFEEEE | EEEEEG |